Curcumin loaded nanofibrous mats for wound healing application

Kulkarni, Anuja S.; Gurav, Deepanjali D.; Khan, Ayesha; Shinde, Vaishali

doi:10.1016/j.colsurfb.2020.110885

Cited by 16 publications

(13 citation statements)

References 38 publications

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“…Kulkarni et al demonstrated the low toxicity of nanofibers containing CUR using NIH3T3 cell line (fibroblasts). This study also revealed that CUR-containing fibers exhibited cytotoxicity in a dose-dependent manner, similar to what we realized in our study [ 28 ]. Gayani also proved the low toxicity towards the lung cell line MRC- 5 of a nanocomposite incorporating CUR [ 29 ].…”

Section: Resultssupporting

confidence: 92%

“…In relation to the CUR-containing surfaces, several previous studies proved the good antimicrobial activity of surfaces functionalized with CUR—namely, films and nanofibers. These surfaces had different purposes, such as food packaging or wound healing [ 28 , 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this case, thiocarbohydrazide gelatin nanofibers together with CUR were used to produce a nanofibrous material by electrospinning. The fibrous material containing CUR exhibited good antibacterial properties and was revealed to show good promise as a wound healing agent [ 28 ]. Gayani et al developed a nanohybrid incorporating CUR and layered double hydroxide that revealed good antibacterial activity against Pseudomonas aeruginosa , Staphylococcus aureus and Enterococcus faecalis , showing even some antibiofilm activity [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Querido

Paulo²,

Hariharakrishnan³

et al. 2021

Antibiotics

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The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity—colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints’ safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for Staphylococcus aureus, Escherichia coli, and Bacillus cereus. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Querido

Paulo²,

Hariharakrishnan³

et al. 2021

Antibiotics

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“…To date, nanotechnology-based strategies have been developed to encapsulate CUR into delivery systems such as nanoparticles, 8 nanoemulsions, 9 nanogels, 10 and nanofibers. 11 In particular, nanoscale covalent organic frameworks (COFs), as a class of newly emerging porous crystalline polymers, have garnered considerable attention over the last decade. 12 Highly ordered structures of COFs can be elaborately designed using reticular framework chemistry and experimentally synthesized through strong covalent bonds.…”

Section: Introductionmentioning

confidence: 99%

“…To date, nanotechnology-based strategies have been developed to encapsulate CUR into delivery systems such as nanoparticles, nanoemulsions, nanogels, and nanofibers . In particular, nanoscale covalent organic frameworks (COFs), as a class of newly emerging porous crystalline polymers, have garnered considerable attention over the last decade .…”

Section: Introductionmentioning

confidence: 99%

Covalent Organic Framework-Incorporated Nanofibrous Membrane as an Intelligent Platform for Wound Dressing

Zou

Wang

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Covalent organic frameworks (COFs) possess fascinating features that have sparked increasing interest as drug carriers in biomedical applications. However, the promising properties of COFs in wound healing have rarely been reported. Herein, a facile one-pot method is reported to prepare a curcumin-loaded COF (CUR@COF) by the condensation reaction and the Schiff base reaction and to further incorporate CUR@COF into polycaprolactone (PCL) nanofibrous membranes (CUR@COF/PCL NFMs) through electrospinning to develop a pH-triggered drug release platform for wound dressing. CUR@COF has a high CUR loading capacity of 27.68%, and CUR@COF/PCL NFMs exhibit increased thermal stability, improved mechanical properties, good biocompatibility, and enhanced antibacterial and antioxidant activities. More importantly, CUR@COF-based membranes show a pH-responsive CUR release profile by protonation under acidic conditions, suggesting the promotion of CUR release from membranes under an acidic extracellular microenvironment. The histopathological analysis and immunofluorescence staining of an in vivo skin defect model indicate that CUR@COF/PCL NFMs can accelerate wound healing and skin regeneration by reducing the expression of inflammatory factors (TNF-α) and enhancing the expression of angiogenesis (VEGF). This work provides a new strategy by employing COF-based drug-encapsulated nanocomposites for wound dressing applications.

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Curcumin loaded as prepared electrospun titania nanofibers for post breast cancer surgeries

Shaban,

Elsaeid,

Ekram

et al. 2023

J Sol-Gel Sci Technol

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In the present study, curcumin-loaded titania nanofibers were synthesized by the conventional sol-gel method via the electrospinning technique using polyvinyl pyrrolidone and characterized via SEM, FTIR, and XRD. Moreover, their contact angle measurement, degradability, water uptake, and mechanical strength were investigated, besides their antibacterial activity, antioxidant activity, sustained drug release, and cytotoxicity against normal cells and breast cancer cell lines. It can be observed that as the concentration of curcumin increased, the mechanical characteristics of the samples were enhanced. The antibacterial results declared that the increase in curcumin concentration enhanced the inhibitory effect against the different pathogens. Moreover, the viability of cells of the normal cell line, seeded on the samples was in the range from 61.4 to 86.5% which indicated its safety on normal cells. However, the cell viability on the cancerous cell line was found to be 33.8, 19.7, 17.9 and 0% for 0, 1, 3, and 5% loaded TiO2/PVP respectively. This lethal effect of the prepared mats on breast cancer cells with nearly no cytotoxic effect on normal cells, favors the usage of the prepared 5% curcumin-loaded TiO2/PVP mat as anticancerous wound healing bandages for postoperative breast cancer surgeries. Graphical Abstract

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Curcumin loaded nanofibrous mats for wound healing application

Cited by 16 publications

References 38 publications

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Covalent Organic Framework-Incorporated Nanofibrous Membrane as an Intelligent Platform for Wound Dressing

Curcumin loaded as prepared electrospun titania nanofibers for post breast cancer surgeries

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