Curcumin loaded as prepared electrospun titania nanofibers for post breast cancer surgeries

Abstract

In the present study, curcumin-loaded titania nanofibers were synthesized by the conventional sol-gel method via the electrospinning technique using polyvinyl pyrrolidone and characterized via SEM, FTIR, and XRD. Moreover, their contact angle measurement, degradability, water uptake, and mechanical strength were investigated, besides their antibacterial activity, antioxidant activity, sustained drug release, and cytotoxicity against normal cells and breast cancer cell lines. It can be observed that as the concentration of curcumin increased, the mechanical characteristics of the samples were enhanced. The antibacterial results declared that the increase in curcumin concentration enhanced the inhibitory effect against the different pathogens. Moreover, the viability of cells of the normal cell line, seeded on the samples was in the range from 61.4 to 86.5% which indicated its safety on normal cells. However, the cell viability on the cancerous cell line was found to be 33.8, 19.7, 17.9 and 0% for 0, 1, 3, and 5% loaded TiO2/PVP respectively. This lethal effect of the prepared mats on breast cancer cells with nearly no cytotoxic effect on normal cells, favors the usage of the prepared 5% curcumin-loaded TiO2/PVP mat as anticancerous wound healing bandages for postoperative breast cancer surgeries. Graphical Abstract