Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network

Zhu, Daoqi; Shao, Meng; Yang, Jiabin; Miao, Fei; Liu, Shiya; Lou, Dandan; Gao, Ruijiao; Liu, Ying; Li, Aiwu; Lv, Ying; Mo, Zhixian; Fan, Qian

doi:10.7150/jca.39511

Cited by 37 publications

(24 citation statements)

References 35 publications

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“…24 Has_circRNA_006660 was upregulated and sponged miR-1276 to increase the radiation sensitivity in nasopharyngeal carcinoma. 25 The effect of circRNAs dysregulation on the radiation sensitivity of cancers remained disunited; however, the upregulation of circ_0062020 further contributed to the facilitation of radiation sensitivity in PCa.…”

Section: Discussionmentioning

confidence: 99%

Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells

Zhi

et al. 2020

CMAR

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Section: Discussionmentioning

confidence: 99%

Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells

Zhi

et al. 2020

CMAR

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“…17 Recent research on NPC has indicated that miR-335 is downregulated in NPC tissues. 24 Zhou et al, 25 showed that decrease in miR-335 level inhibits the proliferation and metastasis of NPC cells through TRIM29. Our experiments demonstrate that the miR-335 inhibitor partly counteracts the suppressive effect of si-ZNRD1-AS1 on cell migration and invasion.…”

Section: Discussionmentioning

confidence: 99%

ZNRD1-AS1 Promotes Nasopharyngeal Carcinoma Cell Invasion and Metastasis by Regulating the miR-335–ROCK1 Axis

Wang

et al. 2020

OTT

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Background: Long noncoding RNAs (lncRNAs) are known as key regulators in many cancer types, but their biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we aim to explore the role of the lncRNA ZNRD1-AS1 in NPC tumor development. Methods: The role of ZNRD1-AS1 in NPC tissues and cells was explored by using quantitative real-time PCR assay. Cellular behavioral experiments were used in testing NPC cell proliferation, invasion, and migration. Luciferase reporter assay, RNA-binding protein immunoprecipitation, and Western blot analysis were used in estimating the associations among ZNRD1-AS1, miR-335, and ROCK1. Results: ZNRD1-AS1 expression was elevated in the NPC tissues and cells, and ZNRD1-AS1 overexpression was positively correlated with advanced TNM stage and the presence of lymph node metastasis. Our biological experiments indicated that ZNRD1-AS1 knockdown reduces NPC cell invasion and metastasis. Further analyses revealed that ZNRD1-AS1 as a ceRNA promotes the migration and invasion of NPC cells by sponging miR-335. We provided evidence that ZNRD1-AS1 facilitates the invasion and metastasis of NPC cells via the miR-335-ROCK1 axis. Conclusion: Our data shed light on the oncogenic role of ZNRD1-AS1 in NPC tumor development, and a promising therapeutic target for NPC was identified.

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“…A study compared the differences in circRNA levels in NPC cell lines after radiotherapy and after treatment with curcumin, using a high-throughput microarray. Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the “hsa_circRNA_102115”-“hsa-miR-335-3p”-“MAPK1” interaction network ( 115 ). At present, although circRNA has shown significant activity in the treatment of cancer, there are few reports on the regulation of circRNA by Active Ingredients of Chinese Medicine, which is also an important direction for future researchers to concern and research.…”

Section: Regulation Of the Anti-tumor Mechanism By Circrna And Other mentioning

confidence: 99%

Anti-Tumor Mechanisms Associated With Regulation of Non-Coding RNA by Active Ingredients of Chinese Medicine: A Review

Liu

Qiu

et al. 2021

Front. Oncol.

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Cancer has become the second leading cause of death worldwide; however, its complex pathogenesis remains largely unclear. Previous research has shown that cancer development and progression are closely associated with various non-coding RNAs, including long non-coding RNAs and microRNAs, which regulate gene expression. Target gene abnormalities are regulated and engaged in the complex mechanism underlying tumor formation, thereby controlling apoptosis, invasion, and migration of tumor cells and providing potentially effective targets for the treatment of malignant tumors. Chemotherapy is a commonly used therapeutic strategy for cancer; however, its effectiveness is limited by general toxicity and tumor cell drug resistance. Therefore, increasing attention has been paid to developing new cancer treatment modalities using traditional Chinese medicines, which exert regulatory effects on multiple components, targets, and pathways. Several active ingredients in Chinese medicine, including ginsenoside, baicalin, and matrine have been found to regulate ncRNA expression levels, thus, exerting anti-tumor effects. This review summarizes the scientific progress made regarding the anti-tumor mechanisms elicited by various active ingredients of Chinese medicine in regulating non-coding RNAs, to provide a theoretical foundation for treating tumors using traditional Chinese medicine.

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Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network

Cited by 37 publications

References 35 publications

<p>Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells</p>

<p>Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells</p>

<p>ZNRD1-AS1 Promotes Nasopharyngeal Carcinoma Cell Invasion and Metastasis by Regulating the miR-335–ROCK1 Axis</p>

Anti-Tumor Mechanisms Associated With Regulation of Non-Coding RNA by Active Ingredients of Chinese Medicine: A Review

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