Curcumin Derivatives as Potential Mosquito Larvicidal Agents against Two Mosquito Vectors, Culex pipiens and Aedes albopictus

Matiadis, Dimitris; Liggri, Panagiota G.V.; Kritsi, Eftichia; Tzioumaki, Niki; Zoumpoulakis, Panagiotis; Papachristos, Dimitrios; Balatsos, George; Sagnou, Marina; Michaelakis, Αntonios

doi:10.3390/ijms22168915

Cited by 18 publications

(19 citation statements)

References 49 publications

(52 reference statements)

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“…Pipiens and Ae. albopictus 43 and hexane extraction of Curcuma longa showed 100% larvicidal activity against Cx. pipiens and Aedes albopictus at 1000 ppm after being treated 24 h 44 .…”

Section: Discussionmentioning

confidence: 99%

Larvicidal and adulticidal effects of some Egyptian oils against Culex pipiens

Baz

Selim

Radwan

et al. 2022

Sci Rep

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Mosquitoes and mosquito-borne diseases represent an increasing global challenge. Plant extract and/or oils could serve as alternatives to synthetic insecticides. The larvicidal effects of 32 oils (1000 ppm) were screened against the early 4th larvae of Culex pipiens and the best oils were evaluated against adults and analyzed by gas chromatography-mass spectrometry (GC mass) and HPLC. All oils had larvicidal activity (60.0–100%, 48 h Post-treatment, and their Lethal time 50 (LT50) values ranged from 9.67 (Thymus vulgaris) to 37.64 h (Sesamum indicum). Oils were classified as a highly effective group (95–100% mortalities), including Allium sativum, Anethum graveolens, Camellia sinensis, Foeniculum vulgare, Nigella sativa, Salvia officinalis, T. vulgaris, and Viola odorata. The moderately effective group (81–92% mortalities) included Boswellia serrata, Cuminum cyminum, Curcuma aromatic, Allium sativum, Melaleuca alternifolia, Piper nigrum, and Simmondsia chinensis. The least effective ones were C. sativus and S. indicum. Viola odorata, Anethum graveolens, T. vulgaris, and N. sativa provide 100% adult mortalities PT with 10, 25, 20, and 25%. The mortality percentages of the adults subjected to 10% of oils (H group) were 48.89%, 88.39%, 63.94%, 51.54%, 92.96%, 44.44%, 72.22%, and 100% for A. sativum, An. graveolens, C. sinensis, F. vulgare, N. sativa, S. officinalis, T. vulgaris, and V. odorata, respectively. Camellia sinensis and F. vulgare were the most potent larvicides whereas V. odorata, T. vulgaris, An. graveolens and N. sativa were the best adulticides and they could be used for integrated mosquito control.

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“…Pipiens and Ae. albopictus 43 and hexane extraction of Curcuma longa showed 100% larvicidal activity against Cx. pipiens and Aedes albopictus at 1000 ppm after being treated 24 h 44 .…”

Section: Discussionmentioning

confidence: 99%

Larvicidal and adulticidal effects of some Egyptian oils against Culex pipiens

Baz

Selim

Radwan

et al. 2022

Sci Rep

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“…By blocking the flow of electrons from cytochrome b to c1, all electron acceptors before cytochrome b are reduced. The ATPase inhibitors act at site V by inhibiting the ATP synthesis catalyst from ADP 45 .…”

Section: Resultsmentioning

confidence: 99%

Mosquito Larvicides of Partial and Combinations Extract of Ethnobotanical Plant from North Sulawesi, Indonesia

Manuahe¹,

Semuel²,

Adil³

et al. 2022

Pakistan J. of Biological Sciences

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Background and Objective: Diseases caused by microbes vectored by mosquitoes are still a health problem in tropical countries today.DHF and Malaria are the two primary diseases vectored by mosquitoes, the morbidity and mortality rates have increased in low countries until now. However, the best way to control these two diseases is to control vectors, namely mosquitoes. Research has been conducted to determine the bioactive content and larvicidal activity of local plant extracts of North Sulawesi. Materials and Methods: The clove and trumpet flower samples were obtained from Minahasa, while the nutmeg samples were obtained from Sitaro Regency. Empirically, people use plant parts to repel mosquitoes. Extraction of plant simplicia was carried out by the maceration method. Qualitative and quantitative methods carried out the phytochemical content analysis. Qualitative analysis uses Harborneʼs (1996) method while qualitative analysis uses the UV Vis Spectrophotometer method. Toxicity tests were carried out on mosquito larvae developed in the laboratory. Results: The results showed that combining clove leaf extract, nutmeg flesh extract and trumpet flower synergistically increased the bioactive content. Flavonoids increased in the combination of extracts compared to partial extracts. The combination of extracts showed the highest toxicity to mosquito larvae (LC 50 : 22.541 mg LG 1 ), while the lowest was the partial extract of clove leaves with LC 50 (54.965 mg LG 1 ). Conclusion:The combination of extracts showed the best toxicity activity on mosquito larvae. Research on bioactive characteristics and toxicity in adult mosquitoes needs to be carried out in the future.

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“…Of all the plants studied so far, different phytochemicals from Curcuma longa (Zingiberales: Zingiberaceae) are well established to possess mosquito larvicidal, pupicidal, adulticidal, and repellent activity 19 . Curcumin and demethoxycurcumin are well reported to have larvicidal activity against dipterans 20 .…”

Section: Introductionmentioning

confidence: 99%

Molecular insights on ar-turmerone as a structural, functional and pharmacophoric analogue of synthetic mosquito repellent DEET by comprehensive computational assessment

Rao

Goswami

Rawal

2022

Sci Rep

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Mosquitoes are vectors for a variety of infectious illnesses, and chemical synthetic insecticides have made it possible to control them effectively. Mosquito repellents are a typical means of keeping mosquitos at bay. Because of its main effectiveness of skin permeability, N , N -Diethyl-meta-toluamide (DEET) is one of the most extensively used mosquito repellents but a dangerous synthetic chemical. DEET was identified about a decade ago to inhibit mosquito's Odorant Binding Protein 1 (OBP1), impairing the mosquito's ability to recognise the host body odour. OBP1 has been identified as a possible target for the development of new mosquito repellents since its discovery. Essential oils from different plants, on the other hand, have been used to repel mosquitos since antiquity. One essential oil from the Curcuma longa (Zingiberales: Zingiberaceae) rhizome display mosquito repellent properties, according to the literature. Furthermore, one of the phytochemicals found in abundance in C. longa essential oil, ar-turmerone, exhibits mosquito repellency as comparable to synthetic DEET. Till date studies on in-silico interaction of natural ar-turmerone with OBP1, which we depict in our current work are scarce. Further, there exist no published reports demonstrating the literary evidence on detailed insights of interaction of DEET with OBP1 along with Molecular Dynamics (MD) simulation studies. We further performed detailed molecular investigations using pharmacophore analysis of ar-turmerone and compared it with DEET, where our findings in the current manuscript unveils for the first time that ar-turmerone is a functional, structural and pharmacophoric analogue of DEET.

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Curcumin Derivatives as Potential Mosquito Larvicidal Agents against Two Mosquito Vectors, Culex pipiens and Aedes albopictus

Cited by 18 publications

References 49 publications

Larvicidal and adulticidal effects of some Egyptian oils against Culex pipiens

Larvicidal and adulticidal effects of some Egyptian oils against Culex pipiens

Mosquito Larvicides of Partial and Combinations Extract of Ethnobotanical Plant from North Sulawesi, Indonesia

Molecular insights on ar-turmerone as a structural, functional and pharmacophoric analogue of synthetic mosquito repellent DEET by comprehensive computational assessment

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