Curcumin, Cardiometabolic Health and Dementia

Kim, Yoona; Clifton, Peter M.

doi:10.3390/ijerph15102093

Cited by 53 publications

(29 citation statements)

References 296 publications

(418 reference statements)

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“…One of the reasons could be the regular intake of turmeric in the routine diet of Indians [25]. CU is a widely studied compound, and many good reviews on its properties and applications are available in the literature [23,[26][27][28][29][30]. It was found in vitro that CU blocks the toxicity of Aβ oligomers (IC 50 = 0.8 µM) [31] and disintegrates preformed Aβ fibrils (EC 50 = 1 µM) [32].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study

et al. 2020

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The amyloid plaques are a key hallmark of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Amyloidogenesis is a complex long-lasting multiphase process starting with the formation of nuclei of amyloid peptides: a process assigned as a primary nucleation. Curcumin (CU) is a well-known inhibitor of the aggregation of amyloid-beta (Aβ) peptides. Even more, CU is able to disintegrate preformed Aβ firbils and amyloid plaques. Here, we simulate by molecular dynamics the primary nucleation process of 12 Aβ peptides and investigate the effects of CU on the process. We found that CU molecules intercalate among the Aβ chains and bind tightly to them by hydrogen bonds, hydrophobic, π–π, and cation–π interactions. In the presence of CU, the Aβ peptides form a primary nucleus of a bigger size. The peptide chains in the nucleus become less flexible and more disordered, and the number of non-native contacts and hydrogen bonds between them decreases. For comparison, the effects of the weaker Aβ inhibitor ferulic acid (FA) on the primary nucleation are also examined. Our study is in good agreement with the observation that taken regularly, CU is able to prevent or at least delay the onset of neurodegenerative disorders.

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Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study

et al. 2020

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“…This flowering plant, curcuma longa, belongs to the Ziangiberaceae family, and is used as an alternative medicine for arthritis [ 122 ]. Turmeric is mainly composed of three curcuminoids including curcumin, demethoxycurcumin, and bisdemethoxycurcumin [ 123 ]. The three categories of curcuminoids are compared in structure.…”

Section: Curcumin As Polyphenolic Phytochemicalmentioning

confidence: 99%

“…With the phenolic O-H group, curcumin thereby belongs to the phenolic compound in structure. The antioxidant properties of curcumin can be achieved through the structure of hydroxyl groups and phenolic rings [ 123 , 124 ].…”

Section: Curcumin As Polyphenolic Phytochemicalmentioning

confidence: 99%

Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases

Kung

Lin

2021

IJMS

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Neuroinflammation and abnormal mitochondrial function are related to the cause of aging, neurodegeneration, and neurotrauma. The activation of nuclear factor κB (NF-κB), exaggerating these two pathologies, underlies the pathogenesis for the aforementioned injuries and diseases in the central nervous system (CNS). CDGSH iron-sulfur domain 2 (CISD2) belongs to the human NEET protein family with the [2Fe-2S] cluster. CISD2 has been verified as an NFκB antagonist through the association with peroxisome proliferator-activated receptor-β (PPAR-β). This protective protein can be attenuated under circumstances of CNS injuries and diseases, thereby causing NFκB activation and exaggerating NFκB-provoked neuroinflammation and abnormal mitochondrial function. Consequently, CISD2-elevating plans of action provide pathways in the management of various disease categories. Various bioactive molecules derived from plants exert protective anti-oxidative and anti-inflammatory effects and serve as natural antioxidants, such as conjugated fatty acids and phenolic compounds. Herein, we have summarized pharmacological characters of the two phytochemicals, namely, alpha-eleostearic acid (α-ESA), an isomer of conjugated linolenic acids derived from wild bitter melon (Momordica charantia L. var. abbreviata Ser.), and curcumin, a polyphenol derived from rhizomes of Curcuma longa L. In this review, the unique function of the CISD2-elevating effect of α-ESA and curcumin are particularly emphasized, and these natural compounds are expected to serve as a potential therapeutic target for CNS injuries and diseases.

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“…33 The possible mechanism of this effect may be due to curcumin's role in insulin secretion by activating phosphoinositide 3 kinase and insulin signaling improvement. 34 Also, aerobic training increases insulin's ability to stimulate muscle glucose uptake. 35 In the Panahi et al 36 study that used 1,000 mg curcumin supplementation over 3 months, weight and BMI in diabetic patients decreased significantly, similar to the results of this study.…”

Section: The Effects Of Aerobic Training Curcumin and Their Interacmentioning

confidence: 99%

The Effect of Curcumin Supplementation and Aerobic Training on Anthropometric Indices, Serum Lipid Profiles, C-Reactive Protein and Insulin Resistance in Overweight Women: A Randomized, Double-Blind, Placebo-Controlled Trial

Dolati

Namiranian

Amerian

et al. 2020

JOMES

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Background: This study aimed to investigate the effects of curcumin supplementation alone and in combination with aerobic training on body composition, glycemic variables, serum levels of C-reactive protein (CRP) and lipid profiles in overweight women. Methods: In this randomized, double-blind, placebo-controlled trial, 40 healthy sedentary overweight females (aged 30-45 years with body mass index [BMI] of 25-30 kg/m 2 ) were randomly assigned to four groups of 10 subjects each: curcumin supplementation (Cur), placebo (Pla), placebo+aerobic training (Pla+Tra), curcumin supplementation+aerobic training (Cur+Tra). Curcumin or placebo capsules (500 mg/day) were administered for 8 weeks. Results: During the intervention, Cur group showed significant reductions in weight, BMI and fasting blood glucose level; Cur+Tra group decreased waist circumference, waist-to-hip ratio, homeostatic model assessment for insulin resistance, serum insulin level, low-density lipoprotein to high-density lipoprotein ratio, and total cholesterol to high-density lipoprotein ratio and increased serum high-density lipoprotein cholesterol. The between-groups analysis indicated increased high-density lipoprotein cholesterol in the Cur and Cur+Tra groups compared to the Pla group. The estimated marginal means of serum CRP were significantly higher in Pla+Tra group than in the Cur and Cur+Tra groups. Conclusion: These findings suggest that the combination of curcumin supplementation with aerobic training more effectively improves glycemic and lipidemic statuses than curcumin supplementation or aerobic training alone.The first two authors contributed equally to this study.Currently, overweight and obesity are problems around the world, especially for women. 1,2 In developing countries, it seems that the prevalence of obesity among women is more than that among men. 3 This condition has an important effect on health impairment, female reproduction 4 and reduced quality of life. 5 Overweight and obesity are associated with diseases such as cardiovascular disease, Original Article Dolati S, et al. Curcumin Supplementation in Overweight Women J Obes Metab Syndr 2020;29:47-57Fleiss equation for sample volume estimation was used in this survey in order to approximate the volume of samples, in which the power of the experiment, the alpha of the equation, and the average alteration were 0.8, 0.05, and 5, respectively. According to the conducted estimation, the sample size was calculated to be 8.81. To be more conservative, among the overweight volunteer women, 10 people were chosen for the experimental group.Exclusion criteria for our study were allergy to curcumin, physical activity or aerobic exercises of any form and type in the past 6 months, pregnancy, underlying or infectious disease, following a special diet, intake of dietary supplements and herbal tea, smoking or other tobacco and hookah consumption, a history of high blood lipids without medication, cardiac failure, taking anti-inflammatory drugs, severe endocrine or metabolic disorders or hospi...

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Curcumin, Cardiometabolic Health and Dementia

Cited by 53 publications

References 296 publications

Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study

Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study

Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases

The Effect of Curcumin Supplementation and Aerobic Training on Anthropometric Indices, Serum Lipid Profiles, C-Reactive Protein and Insulin Resistance in Overweight Women: A Randomized, Double-Blind, Placebo-Controlled Trial

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