The Effect of Curcumin Supplementation and Aerobic Training on Anthropometric Indices, Serum Lipid Profiles, C-Reactive Protein and Insulin Resistance in Overweight Women: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract

Background: This study aimed to investigate the effects of curcumin supplementation alone and in combination with aerobic training on body composition, glycemic variables, serum levels of C-reactive protein (CRP) and lipid profiles in overweight women. Methods: In this randomized, double-blind, placebo-controlled trial, 40 healthy sedentary overweight females (aged 30-45 years with body mass index [BMI] of 25-30 kg/m 2 ) were randomly assigned to four groups of 10 subjects each: curcumin supplementation (Cur), placebo (Pla), placebo+aerobic training (Pla+Tra), curcumin supplementation+aerobic training (Cur+Tra). Curcumin or placebo capsules (500 mg/day) were administered for 8 weeks. Results: During the intervention, Cur group showed significant reductions in weight, BMI and fasting blood glucose level; Cur+Tra group decreased waist circumference, waist-to-hip ratio, homeostatic model assessment for insulin resistance, serum insulin level, low-density lipoprotein to high-density lipoprotein ratio, and total cholesterol to high-density lipoprotein ratio and increased serum high-density lipoprotein cholesterol. The between-groups analysis indicated increased high-density lipoprotein cholesterol in the Cur and Cur+Tra groups compared to the Pla group. The estimated marginal means of serum CRP were significantly higher in Pla+Tra group than in the Cur and Cur+Tra groups. Conclusion: These findings suggest that the combination of curcumin supplementation with aerobic training more effectively improves glycemic and lipidemic statuses than curcumin supplementation or aerobic training alone.The first two authors contributed equally to this study.Currently, overweight and obesity are problems around the world, especially for women. 1,2 In developing countries, it seems that the prevalence of obesity among women is more than that among men. 3 This condition has an important effect on health impairment, female reproduction 4 and reduced quality of life. 5 Overweight and obesity are associated with diseases such as cardiovascular disease, Original Article Dolati S, et al. Curcumin Supplementation in Overweight Women J Obes Metab Syndr 2020;29:47-57Fleiss equation for sample volume estimation was used in this survey in order to approximate the volume of samples, in which the power of the experiment, the alpha of the equation, and the average alteration were 0.8, 0.05, and 5, respectively. According to the conducted estimation, the sample size was calculated to be 8.81. To be more conservative, among the overweight volunteer women, 10 people were chosen for the experimental group.Exclusion criteria for our study were allergy to curcumin, physical activity or aerobic exercises of any form and type in the past 6 months, pregnancy, underlying or infectious disease, following a special diet, intake of dietary supplements and herbal tea, smoking or other tobacco and hookah consumption, a history of high blood lipids without medication, cardiac failure, taking anti-inflammatory drugs, severe endocrine or metabolic disorders or hospi...

Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade‐assessed systematic review and dose–response meta‐analysis of randomized controlled trials

“…Two additional studies were removed in which the duration of the intervention was less than 2 weeks (Amalraj et al, 2020; Shadnoush et al, 2020). Eventually, 60 eligible RCTs were included in the present systematic review and meta‐analysis; the outcomes assessed in each intervention includes the following: BMI ( n = 45) (Adab et al, 2019; Akazawa et al, 2013; Alqahtani, 2021; Alvarenga et al, 2020; Amalraj et al, 2017; Amin et al, 2015; Arabnezhad et al, 2022; Asadi et al, 2019; Asan et al, 2020; Bateni et al, 2021; Chashmniam et al, 2019; Cicero et al, 2020; Darmian et al, 2021; Dolati et al, 2020; Ebrahimkhani et al, 2020; Farzad et al, 2020; Funamoto et al, 2019; Ghaffari et al, 2018; Hariri et al, 2020; Hodaei et al, 2019; Jamilian et al, 2020; Kalhori et al, 2022; Karandish et al, 2021; Kocher et al, 2016; Mirhafez et al, 2019, 2021; Mohammadi et al, 2018; Neta et al, 2021; Osali, 2020; Panahi, Khalili, et al, 2017; Panahi, Kianpour, et al, 2017; Pourhabibi‐Zarandi et al, 2022; Rahimi et al, 2016; Rezaie et al, 2021; Saadati et al, 2019; Saberi‐Karimian et al, 2018, 2020; Salehi et al, 2021; Santos‐Parker et al, 2018; Silva et al, 2019; Sousa et al, 2021; Sugawara et al, 2012; Tabaee et al, 2021; Uchio et al, 2021; Yang et al, 2014), BW ( n = 38) (Adab et al, 2019; Akazawa et al, 2013; Alqahtani, 2021; Amalraj et al, 2017; Amin et al, 2015; Asadi et al, 2019; Asan et al,…”

“…Table 1 presents the characteristics of the 60 RCTs that were a part of the current systematic review and meta‐analysis. These RCTs, conducted in Thailand (Chuengsamarn et al, 2012, 2014), Japan (Akazawa et al, 2013; Funamoto et al, 2019; Sugawara et al, 2012; Uchio et al, 2021), Taiwan (Yang et al, 2014), Pakistan (Amin et al, 2015), Germany (Kocher et al, 2016), Iran (Adab et al, 2019; Adibian et al, 2019; Arabnezhad et al, 2022; Asadi et al, 2019; Bateni et al, 2021; Chashmniam et al, 2019; Darmian et al, 2021; Dolati et al, 2020; Ebrahimkhani et al, 2020; Farzad et al, 2020; Ghaffari et al, 2018; Hariri et al, 2020; Hodaei et al, 2019; Jamilian et al, 2020; Jazayeri‐Tehrani et al, 2018; Kalhori et al, 2022; Karandish et al, 2021; Mirhafez et al, 2019, 2021; Mohammadi et al, 2018; Navekar et al, 2017; Osali, 2020; Panahi et al, 2016; Panahi, Khalili, et al, 2017; Panahi, Kianpour, et al, 2017; Pourhabibi‐Zarandi et al, 2022; Rahimi et al, 2016; Rezaie et al, 2021; Saadati et al, 2019; Saberi‐Karimian et al, 2018, 2020; Salahshooh et al, 2017; Salehi et al, 2021; Tabaee et al, 2021), India (Amalraj et al, 2017; Krishnareddy et al, 2018; Srinivasan et al, 2019), Turkey (Asan et al, 2020), Italy (Cicero et al, 2020), Saudi Arabia (Alqahtani, 2021), China (Qiao et al, 2021), Brazil (Alvarenga et al, 2020; Neta et al, 2021; Silva et al, 2019; Sousa et al,…”

“…Regarding the kinds of curcumin supplements used, 38 studies used curcumin (Adibian et al, 2019; Akazawa et al, 2013; Alqahtani, 2021; Amalraj et al, 2017; Arabnezhad et al, 2022; Campbell et al, 2017, 2019; Chuengsamarn et al, 2012, 2014; Cicero et al, 2020; Dolati et al, 2020; Ebrahimkhani et al, 2020; Farzad et al, 2020; Funamoto et al, 2019; Hodaei et al, 2019; Ismail et al, 2014; Jamilian et al, 2020; Karandish et al, 2021; Lopresti et al, 2015; Mirhafez et al, 2019, 2021; Mohammadi et al, 2018; Neta et al, 2021; Panahi et al, 2016; Panahi, Khalili, et al, 2017; Panahi, Kianpour, et al, 2017; Pourhabibi‐Zarandi et al, 2022; Qiao et al, 2021; Rezaie et al, 2021; Saadati et al, 2019; Saberi‐Karimian et al, 2020; Salahshooh et al, 2017; Salehi et al, 2021; Santos‐Parker et al, 2018; Silva et al, 2019; Sousa et al, 2021; Tabaee et al, 2021; Yang et al, 2014), 10 studies administered turmeric (Adab et al, 2019; Alvarenga et al, 2020; Amin et al, 2015; Darmian et al, 2021; Ghaffari et al, 2018; Kalhori et al, 2022; Navekar et al, 2017; Nieman et al, 2012; Srinivasan et al, 2019; Uchio et al, 2021), seven studies used highly absorbable curcumin (Asan et al, 2020; Chashmniam et al, 2019; Hariri et al, 2020; Kocher et al, 2016; Krishnareddy et al, 2018; Saberi‐Karimian et al, 2018; Sugawara et al, 2012), and five studies use...…”

“…It should be mentioned that we made sure that control groups received the same additional treatment. RCTs were performed on healthy individuals (Akazawa et al, 2013; Alqahtani, 2021; Amin et al, 2015; Campbell et al, 2017, 2019; Cicero et al, 2020; Dolati et al, 2020; Farzad et al, 2020; Ismail et al, 2014; Karandish et al, 2021; Nieman et al, 2012; Salehi et al, 2021; Santos‐Parker et al, 2018; Sugawara et al, 2012; Uchio et al, 2021), patients with type 2 diabetes and hyperlipidemia (Adab et al, 2019; Adibian et al, 2019; Asadi et al, 2019; Chuengsamarn et al, 2014; Darmian et al, 2021; Ebrahimkhani et al, 2020; Hodaei et al, 2019; Kocher et al, 2016; Neta et al, 2021; Panahi, Khalili, et al, 2017; Rahimi et al, 2016; Sousa et al, 2021; Srinivasan et al, 2019), individuals with prediabetes and impaired glucose tolerance (Chuengsamarn et al, 2012; Funamoto et al, 2019), metabolic syndrome (Bateni et al, 2021; Osali, 2020; Panahi et al, 2016; Saberi‐Karimian et al, 2018; Salahshooh et al, 2017; Yang et al, 2014), nonalcoholic fatty liver disease (NAFLD) (Chashmniam et al, 2019; Ghaffari et al, 2018; Hariri et al, 2020; Jazayeri‐Tehrani et al, 2018; Kalhori et al, 2022; Mirhafez et al, 2019, 2021; Navekar et al, 2017; Panahi, Kianpour, et al, 2017; Saadati et al, 2019; Saberi‐Karimian et al, 2020), rheumatoid arthritis (Amalraj et al, 2017; Pourhabibi‐Zarandi et al, 2022), polycystic ovary syndrome and dysmenorrhea (Arabnezhad et al, 2022; Asan et al, 2020; Jamilian et al, 2...…”

“…studies used curcumin(Adibian et al, 2019;Akazawa et al, 2013;Alqahtani, 2021;Arabnezhad et al, 2022;Campbell et al, 2017Campbell et al, , 2019Chuengsamarn et al, 2012Chuengsamarn et al, , 2014Cicero et al, 2020;Dolati et al, 2020;Ebrahimkhani et al, 2020;Farzad et al, 2020;Funamoto et al, 2019;Hodaei et al, 2019;Ismail et al, 2014;Jamilian et al, 2020;Karandish et al, 2021;Lopresti et al, 2015;Mirhafez et al, 2019Mirhafez et al, , 2021Mohammadi et al, 2018;Neta et al, 2021;Panahi et al, 2016;Panahi, Khalili, et al, 2017;Panahi, Kianpour, et al, 2017;Pourhabibi-Zarandi et al, 2022;Qiao et al, 2021;Rezaie et al, 2021;Saadati et al, 2019;Saberi-Karimian et al, 2020;Salahshooh et al, 2017;Salehi et al, 2021;Santos-Parker et al, 2018;Silva et al, 2019;Sousa et al, 2021;Tabaee et al, 2021;Yang et al, 2014), 10 studies administered turmeric(Adab et al, 2019;Alvarenga et al, 2020;Amin e...…”