Curcumin ameloriates heat stress via inhibition of oxidative stress and modulation of Nrf2/HO-1 pathway in quail

Şahin, Kazım; Orhan, Cemal; Tuzcu, Zeynep; Tuzcu, Mehmet; Şahin, Nurhan

doi:10.1016/j.fct.2012.08.029

Cited by 116 publications

(79 citation statements)

References 55 publications

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“…This result is in agreement with studies showing that artificially supplementing the diet of thermally stressed animals with various antioxidants improves their oxidative balance (Sahin et al, 2003;Sahin et al, 2006;Ates et al, 2006;Cao et al, 2011;Sahin et al, 2012a;Sahin et al, 2012b;Sahin et al, 2013). However, a fundamental difference between these studies and ours is that from our study it appears that animals can actively supplement their diet with antioxidants when exposed to temperatures outside their thermoneutral zone.…”

Section: Research Articlesupporting

confidence: 38%

“…If animals are not able to mount concomitantly an appropriate antioxidant defense system, being exposed to such temperatures results in increased oxidative damage (Al-Azraqi, 2008;Costantini et al, 2012). Interestingly, temperatureinduced oxidative damage can be reduced by supplementing the diet of animals with diverse antioxidants (Sahin et al, 2003;Sahin et al, 2006;Ates et al, 2006;Cao et al, 2011;Sahin et al, 2012a;Sahin et al, 2012b;Sahin et al, 2013). However, whether animals are able to actively supplement their diet with antioxidants to alleviate temperature-induced oxidative stress remains entirely unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Each temperature treatment lasted 48 h (Fig. 5), because oxidative markers may vary after a few hours to several days of exposure to temperature treatment in birds (Sahin et al, 2003;Sahin et al, 2006;Lin et al, 2008;Sahin et al, 2012a;Sahin et al, 2012b). This first treatment allowed us to examine in which direction and in which proportion oxidative markers vary in Gouldian finches exposed to different thermal conditions.…”

Section: Research Articlementioning

confidence: 99%

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Self-supplementation and effects of dietary antioxidants during acute thermal stress

Beaulieu

Haas

Schaefer

2013

Journal of Experimental Biology

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Thermal stress leads to increased production of reactive oxygen species. If an organism is not able to simultaneously mount an efficient antioxidant defense system, this may lead to increased oxidative damage, which is potentially deleterious in terms of health and fitness. Exposure to cold or heat is therefore expected to be associated with a high demand for antioxidants. In agreement, several studies have shown that supplementing the diet of thermally stressed organisms with antioxidants leads to a reduction of oxidative damage. However, whether organisms can actively supplement their diet with antioxidants to alleviate temperature-induced oxidative damage is unknown. Here, we show that captive Gouldian finches (Erythrura gouldiae) supplement their diet more with seeds rich in antioxidants below than within their thermoneutral zone. Moreover, having access to seeds rich in antioxidants at temperatures below thermoneutrality decreases their oxidative damage. These results indicate that, when facing a thermal challenge, animals are able to take advantage of the antioxidant properties of their food to improve their oxidative balance. Having access to food resources rich in antioxidants may therefore be of primary importance for organisms in their natural habitat, as it may help them to cope with oxidative constraints due to challenging temperature regimes.

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Section: Research Articlesupporting

confidence: 38%

Section: Introductionmentioning

confidence: 99%

Section: Research Articlementioning

confidence: 99%

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Self-supplementation and effects of dietary antioxidants during acute thermal stress

Beaulieu

Haas

Schaefer

2013

Journal of Experimental Biology

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“…TRP-reduced malondialdehyde (MDA) concentrations, which indicates an improved antioxidant and detoxifying status of birds Hosseini-Vashan et al, 2012Wang et al, 2015). In this line of research, pure curcumin has been tested in heat-stressed quails, and it was established that curcumin ameliorates heat stress through modulating the hepatic nuclear transcription factors and heat shock protein 70 (Sahin et al, 2012). TRP or curcuminoids have been successfully applied to raise the immune status of farm birds after vaccination, it was noted that antibody titers were increased by supplementation with turmeric in feed (Faghani et al, 2014).…”

Section: −1mentioning

confidence: 99%

Effects of turmeric rhizome powder and curcumin in poultry production. A review

Guil‐Guerrero

Ramos

Paredes³

et al. 2017

J. Anim. Feed Sci.

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“…Curcumin, a polyphenol of Curcuma longa, reported for its beneficial anti-inflammatory, antioxidant, antimutagenic and anticancer activities. [10][11][12] Effective in protecting heat induced oxidant stress, 13 chromiuminduced renal damage, 14 cisplatin-induced hepatotoxicity, 15 aluminum-induced mitochondrial dysfunction in vivo. 16 Whereas, capsaicin, a component of Capsicum annum exerts various pharmacological properties, including antioxidant, anti-inflammatory and anti-epileptic effects.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Dietary Curcumin and Capsaicin on LPS-Induced Inflammation in Mice

Vasanthkumar¹,

Hanumanthappa²,

Prabhakar³

2018

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Objective:The current study aimed to evaluate the anti-inflammatory potency of combined curcumin and capsaicin against lipopolysaccharide (LPS) induced organ damage in mice. Methods: Adult male albino mice were distributed into five experimental groups for treatment with olive oil, LPS, curcumin, capsaicin and their combination, respectively, for 7 days prior to LPS induced inflammation. At the end of the experiment, blood samples were collected and used for the analysis of serum non-specific enzymes including serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin (TB), urea, creatinine and sugar, while the organ homogenates were subjected for the evaluation of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutothione S transferase (GST), nitric oxide (NO); lipid peroxidation (LPO) and it was further confirmed by histopathological study of different organs. Results and Conclusion: Curcumin, capsaicin and their combination had shown significant restoration of non-specific serum enzymes, antioxidant enzymes and attenuated inflammatory cells infiltration thereby preventing tissue/organ damage in LPS-challenged mice. However, the protective effect was found to be more when the two compounds were fed in combination. This beneficial potency of combined spice treatment is may be due to the contribution of diversified active moieties of curcumin and capsaicin in combination compared to individual molecules.

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Curcumin ameloriates heat stress via inhibition of oxidative stress and modulation of Nrf2/HO-1 pathway in quail

Cited by 116 publications

References 55 publications

Self-supplementation and effects of dietary antioxidants during acute thermal stress

Self-supplementation and effects of dietary antioxidants during acute thermal stress

Effects of turmeric rhizome powder and curcumin in poultry production. A review

Protective Effect of Dietary Curcumin and Capsaicin on LPS-Induced Inflammation in Mice

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