Curcumin alleviates liver oxidative stress in type 1 diabetic rats

Abstract

The aim of the present study was to determine the effects of curcumin on antioxidants using a rat model of type 1 diabetes. Seven-week-old male Sprague-Dawley rats were injected with Streptozotocin (STZ) intraperitoneally to induce this model, and then treated with 1.0% curcumin (weight ratio) mixed in their diet for 21 days. The present study included three groups: Control group (NC), diabetic rat model group (DC) and a curcumin treated group (Diab-Cur). The results demonstrated that curcumin treatment markedly decreased the blood glucose levels, plasma malondialdehyde concentration and plasma activity of glutathione peroxidase (GSH-Px) and catalase (CAT); however, it increased the plasma superoxide dismutase (SOD) and insulin levels. Curcumin treatment increased the expression of the CAT, GSH-Px, HO-1 and norvegicus NAD(P)H quinone dehydrogenase 1, and decreased the SOD1 expression, which, led to a diminished oxidative stress status. In addition, curcumin treatment significantly increased the protein expression of Keap1 in the Diab-Cur group when compared with the DC group, decreased cytosolic concentrations of Nrf2 while increasing nuclear accumulation of Nrf2. The results provide evidence that oxidative stress in the STZ-induced diabetic rat model may be attenuated by curcumin via the activation of the Keap1-Nrf2-ARE signaling pathway, as evidenced by a decrease in the blood glucose concentration and an increase in the transcription of several antioxidant genes.

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

“…Curcumin treatment in the three diabetic treated groups showed a significant decrease in blood glucose levels in comparison to the untreated DM group. These data are consistent with previous reports where type 1 diabetic male SD rats were treated with 1% curcumin in diet for 3 weeks, were accompanied with a notable increase in levels of plasma insulin (Xie, Wu, Shen, Li, & Wu, ). Another recent study, in which curcumin nanoparticles were used to overcome the low bioavailability, stated that curcumin had significant antidiabetic effects with good glycemic control (Jaafari, Abnous, Mobarhan, & Oskuee, ).…”

“…Diabetic patients often suffer from fatty liver disease and other liver disorders. It was found that STZ‐induced diabetic rats fed dietary curcumin for 8 weeks, showed a reduction in liver weight and lipid peroxidation products in the plasma and urine (Xie et al, ). The effects of curcumin on dyslipidemia was also demonstrated by other groups (Xie et al, ).…”

“…It was found that STZ‐induced diabetic rats fed dietary curcumin for 8 weeks, showed a reduction in liver weight and lipid peroxidation products in the plasma and urine (Xie et al, ). The effects of curcumin on dyslipidemia was also demonstrated by other groups (Xie et al, ). Improvement in serum lipids by curcumin may be attributed to the induction of peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) activity that is linked to adipogenesis.…”

Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2‐related factor 2 activation

“…Previous studies have shown that curcumin could uncouple the keap1-Nrf2 complex, an event which leads to the stabilisation of Nrf2 followed by its subsequent transport into cell nuclei, all of which leading to the transcription of several antioxidant genes (HO-1, NQO-1, GSH-Px, CAT and SOD1) involved in antioxidant responses (Xie, Wu, Shen, Li, & Wu, 2018). But intriguingly, the spermatozoa only have nuclei with little cytoplasm surrounding the flagellum, making it difficult to observe the translocation of Nrf2 and explain the relation between Nrf2 and expression level of antioxidant genes.…”

Curcumin ameliorates cisplatin‐induced cystopathy via activating NRF2 pathway

“…Curcumin has health benefits such as antioxidant, anti‐inflammatory, and anticancer properties . ZHENGLU XIE reported that curcumin could attenuate oxidative stress in the diabetic rat‐induced by STZ through activation of the Keap1‐Nrf2‐ARE signaling pathway . Curcumin may be employed to treat cisplatin‐induced bladder dysfunction considering its safety, cost‐effectiveness, and beneficial effects …”