Curcuma Longa;

Abstract

… Objectives: To analyze the hepatoprotective effects of Curcuma longa (CL) against carbon tetrachloride (CCl 4 ) induced chemical injury in experimental rats. Study Design: Experimental study. Setting: Indus Medical College in collaboration with Animal house of Sindh Agriculture University Tando Jam. Period: March 2016 to August 2016. Methodology: Sixty adult male rats were selected according to inclusion and exclusion criteria. Rats were divided randomly into 3 groups -as group A. controls, group B -received CCl 4 and group C-received CCl 4 + CL orally. Blood samples were taken after 4 weeks of therapy by cardiac puncture. 5μ thick liver tissue sections were stained for light microscopy examination. Analysis of data was performed on Statistix 9.0 (USA) at statistical significance of p-value ≤ 0.5. Results: Liver cell biochemical markers of injury and histopathological examination show the Curcuma longa is effective against carbon tetrachloride induced liver injury (P <0.05). Liver histology was improved by the curcuma longa therapy. Conclusion: Liver aminotransferase and histology were improved significantly by the curcuma longa therapy in carbon tetrachloride induced liver injury.