The global pandemic of COVID-19 has impacted every sphere of human life across all nations of the world. Countries adapted and responded to the crisis in different ways with varied outcomes and different degrees of success in mitigation efforts. Studies have examined institutional and policy-based responses to the pandemic. However, to gain a holistic understanding of the pandemic response strategy and its effectiveness, it is also important to understand the cultural foundations of a society driving its response behavior. Towards that end, this entry focuses on a few key cultural dimensions of difference across countries and proposes that national culture is related to the protective behavior adopted by societies during COVID-19. The cultural dimensions examined in relation to COVID-19 include the dimensions of individualism vs. collectivism, power distance, uncertainty avoidance, masculinity and femininity, and future orientation. Inferences are drawn from academic research, published data, and discernible indicators of social behavior. The provides pointers for each dimension of culture and proposes that cultural awareness be made an important element of policy making while responding to crises such as COVID-19.