“…The construction of a stimuli-responsive nanosystem by the method of supramolecular assembly has attracted extensive attention benefitting from its simple composition, easy adjustment, and good repeatability. − In particular, the use of biocompatible water-soluble macrocyclic compounds, such as cyclodextrin, − p -sulfonatocalixarene, − cucurbituril, − and modified pillararene, − to construct stimuli-responsive supramolecular assemblies has shown many promising applications in the biomedical field. It is worth noting that organs, body fluids, and cell compartments have their unique pH values in living organisms.…”