Cubic Nanoparticles for Magnetic Hyperthermia: Process Optimization and Potential Industrial Implementation

Sánchez, Omar Sánchez; Castelo-Grande, Teresa; Augusto, Paulo A.; Compaña, J.M.; Barbosa, Domingos

doi:10.3390/nano11071652

Cited by 9 publications

(12 citation statements)

References 22 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, since the concentration effect is now determined, the shape effect should be targeted in future experiments. In Avugadda et al [36] and Abenojar et al [37], the cubic-shaped particles showed a higher SAR than the spherical-shaped, in addition to the promising results shown in Sánchez et al [18], so perhaps the cubic-shaped would perform even better with non-conventional signals.…”

Section: Discussionmentioning

confidence: 88%

See 1 more Smart Citation

Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms

et al. 2021

View full text Add to dashboard Cite

For decades now, conventional sinusoidal signals have been exclusively used in magnetic hyperthermia as the only alternating magnetic field waveform to excite magnetic nanoparticles. However, there are no theoretical nor experimental reasons that prevent the use of different waveforms. The only justifiable motive behind using the sinusoidal signal is its availability and the facility to produce it. Following the development of a configurable alternating magnetic field generator, we aim to study the effect of various waveforms on the heat production effectiveness of magnetic nanoparticles, seeking to prove that signals with more significant slope values, such as the trapezoidal and almost-square signals, allow the nanoparticles to reach higher efficiency in heat generation. Furthermore, we seek to point out that the nanoparticle power dissipation is dependent on the waveform’s slope and not only the frequency, magnetic field intensity and the nanoparticle size. The experimental results showed a remarkably higher heat production performance of the nanoparticles when exposed to trapezoidal and almost-square signals than conventional sinusoidal signals. We conclude that the nanoparticles respond better to the trapezoidal and almost-square signals. On the other hand, the experimental results were used to calculate the normalized power dissipation value and prove its dependency on the slope. However, adjustments are necessary to the coil before proceeding with in vitro and in vivo studies to handle the magnetic fields required.

show abstract

Section: Discussionmentioning

confidence: 88%

“…In Sánchez et al [18], the cubic-shaped NPs were discussed, followed by their optimization for MHT application and their potential industrial implementation. They showed good heating performance, making them a promising type of particles for MHT.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The cubic shape is considered the best for magnetic hyperthermia applications. 73 The SAR values of iron oxide nanoparticles of different shapes follow the order SAR nanocubes 4 SAR nanoflowers 4 SAR nano-octahedra 4 SAR truncated MNPs 4 SAR nanorods . 74 The surface coating can also affect the heating efficacy of MNPs.…”

Section: Review Materials Advancesmentioning

confidence: 99%

Therapeutic applications of magnetic nanoparticles: recent advances

Roy

Kritika

2022

Mater. Adv.

View full text Add to dashboard Cite

show abstract

“…For example, NPs have a high surface-to-volume ratio that provides extremely reactive and versatile properties. Magnetic nanoparticles (MNPs) have found numerous applications in biomedicine fields, such as magnetophoresis, drug delivery, nuclear magnetic resonance imaging (NMRI), and hyperthermia [2,3]. Additionally, MNPs can be manipulated by high gradients of magnetic fields [1].…”

Section: Introductionmentioning

confidence: 99%

A Ferrofluid with High Specific Absorption Rate Prepared in a Single Step Using a Biopolymer

et al. 2022

View full text Add to dashboard Cite

An exhaustive characterization of the physicochemical properties of gum arabic (GA)-coated Fe3O4 magnetic nanoparticles was conducted in this work. These nanoparticles were obtained via the in-situ coprecipitation method (a fast single-step method) in two GA:Fe ratios, 10:1 and 20:1, respectively. Several experimental techniques were applied in the characterization process, all of them described below. Using Transmission Electron Microcopy images, they were shown to have spherical-like morphology with 11 nm diameter. The Fourier Transform Infrared spectra confirmed the attachment of the GA on the surface of the magnetic nanoparticles (MNPs), providing good colloidal stability from pH 7 to 8. The thickness of the coatings (1.7 nm and 1.1 nm) was determined using thermogravimetric measurements. A high specific absorption rate and superparamagnetic properties were determined using alternant and static magnetic fields, respectively. The GA-coated MNPs were non-cytotoxic, according to tests on HT-29 human intestine cells. Additionally, HT-29 cells were exposed to magnetic fluid hyperthermia at 530 kHz, and the induction of cell death by the magnetic field, due to the heating of GA-coated MNP, was observed.

show abstract

Cubic Nanoparticles for Magnetic Hyperthermia: Process Optimization and Potential Industrial Implementation

Cited by 9 publications

References 22 publications

Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms

Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms

Therapeutic applications of magnetic nanoparticles: recent advances

A Ferrofluid with High Specific Absorption Rate Prepared in a Single Step Using a Biopolymer

Contact Info

Product

Resources

About