A Ferrofluid with High Specific Absorption Rate Prepared in a Single Step Using a Biopolymer

Abstract

An exhaustive characterization of the physicochemical properties of gum arabic (GA)-coated Fe3O4 magnetic nanoparticles was conducted in this work. These nanoparticles were obtained via the in-situ coprecipitation method (a fast single-step method) in two GA:Fe ratios, 10:1 and 20:1, respectively. Several experimental techniques were applied in the characterization process, all of them described below. Using Transmission Electron Microcopy images, they were shown to have spherical-like morphology with 11 nm diameter. The Fourier Transform Infrared spectra confirmed the attachment of the GA on the surface of the magnetic nanoparticles (MNPs), providing good colloidal stability from pH 7 to 8. The thickness of the coatings (1.7 nm and 1.1 nm) was determined using thermogravimetric measurements. A high specific absorption rate and superparamagnetic properties were determined using alternant and static magnetic fields, respectively. The GA-coated MNPs were non-cytotoxic, according to tests on HT-29 human intestine cells. Additionally, HT-29 cells were exposed to magnetic fluid hyperthermia at 530 kHz, and the induction of cell death by the magnetic field, due to the heating of GA-coated MNP, was observed.

The Fluorescent Cell Line SW620-GFP Is a Valuable Model to Monitor Magnetic Hyperthermia

“…This is an important property because the negative charge of the SPIONs promotes their endocytosis and, at the same time, the ferrofluid maintains colloidal stability in biological experiments, where the pH of the system has to be very close to pH = 7.4. A measurement of the polydispersity index PDI when pH ≈ 6.8 reaches PDI ≈ 0.22, which is a relatively low homogeneity (according to the size distribution of Figure 1c), but it is considered sufficient for magneto-calorimeter tests and magnetic hyperthermia applications [20,23,28,29]. The magnetic saturation of the SPIONs (red line) was 50 emu/g approximately 30% lower than the one of pure magnetite (black line) (Figure 3a).…”

Structural, Thermal, and Magnetic Characterization Analysis of Synthesized Fe₃O₄-Spinel Ferrite Nanoparticles

“…When ferrite materials display superparamagnetic behaviour, their importance increases amazingly in the field of medical technology. They have shown potential biomedical applications as magnetic drug carriers, hyperthermia agents, imaging tools for magnetic resonance, and magnetic separators [2][3][4][5][6][7][8]. Therefore, superparamagnetic properties are highly desired in spinel ferrites.…”

Green synthesis of biocompatible Fe 3 O 4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic- hyperthermia applications

“…Magnetic resonance imaging (MRI), contrast reagent materials, magnetic hyperthermia (MHT) cancer treatment, biosensors, and drug delivery are some potential therapeutic applications for SPIONs with nano-sizes less than 50nm [11][12][13] . The biocompatibility SPIONs are frequently utilized in waste water treatment of several organic dyes as a ferrofluid, metal adsorbent, antibacterial agent, and antifungal reagent [14][15][16][17][18][19][20] . Additionally, biocompatible Fe3O4 MNP hybrid NPs have minimal toxicity, as do doped Fe3O4-based materials, which have high magnetization saturation 21 .…”