CTX-M and TEM as Predominant Types of Extended Spectrum β-Lactamases Among Serratia marcescens Isolated From Solid Organ Recipients

Młynarczyk, A; Szymanek, K.; Sawicka-Grzelak, A.; Pazik, J.; Buczkowska, T.; Durlik, M.; Łągiewska, B; Pacholczyk, Marek; Chmura, A.; Pączek, Leszek; Młynarczyk, G.

doi:10.1016/j.transproceed.2009.08.011

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…Extended-spectrum beta-lactamases (ESBLs) have been found in an increasing number of hospital strains, which is consistent with our findings in the evaluated wards [7]. In light of this common occurrence of ESBLs, the extensive use of carbapenems is understandable, as ESBL-producing strains remain susceptible to carbapenems.…”

Section: Discussionsupporting

confidence: 91%

Molecular Analysis of Carbapenem-resistant Strains of Pseudomonas aeruginosa Isolated From Patients Hospitalized in Various Transplantation Wards Between 2008 and 2011

Kosykowska

Szymanek-Majchrzak

Walthoffen

et al. 2014

Transplantation Proceedings

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Section: Discussionsupporting

confidence: 91%

Molecular Analysis of Carbapenem-resistant Strains of Pseudomonas aeruginosa Isolated From Patients Hospitalized in Various Transplantation Wards Between 2008 and 2011

Kosykowska

Szymanek-Majchrzak

Walthoffen

et al. 2014

Transplantation Proceedings

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“…On the other, other beta-lactamases, including CTX-M3, IMP-type, as well as TEMtype have also been identified in Serratia spp. 14,[46][47][48] Specifically, the issue of the emergence of carbapenem resistance Serratia strains is of major importance. In our study, both imipenem and meropenem exhibited high antimicrobial activity rates against the tested Serratia marcescens and non-marcescens isolates.…”

Section: Discussionmentioning

confidence: 99%

“…7,[9][10][11][12] In addition, another issue that intensified the importance of Serratia infections is the emergence of multi-drug resistant Serratia isolates, and particularly extended spectrum beta-lactamase producing Serratia isolates (ESBLs). [13][14][15] In this regard, the aim of our study was to present our experience regarding the characteristics and outcomes of patients with infections caused from Serratia spp. at a university hospital of a region with relatively high levels of antimicrobial resistance.…”

Section: Introductionmentioning

confidence: 99%

Serratia infections in a general hospital: characteristics and outcomes

Samonis

Vouloumanou

Christofaki

et al. 2011

Eur J Clin Microbiol Infect Dis

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We aimed to present our experience regarding infections caused by Serratia spp. in a region with relatively high antimicrobial resistance rates. We retrospectively reviewed the databases of the microbiological laboratory of the University Hospital of Heraklion, Crete (2/2004-12/2009). A total of 77 patients [67.5% men, mean age ± standard deviation (SD) = 56.9 ± 24.5 years) were identified; 37.7% were outpatients. Sixty-five (84.4%) of the 77 included patients had a Serratia marcescens isolate; the remaining 12 patients had a non-marcescens Serratia spp. The most frequently observed infections were respiratory tract infection (32.5%) and keratitis/endophthalmitis (20.8%). Seventy-three (94.9%) patients were cured. Four deaths were observed; three of them were considered as attributed to the Serratia infection. No difference was found regarding the characteristics and outcomes between patients with Serratia marcescens and non-marcescens infections. In addition, antipseudomonal penicillins and their combinations with beta-lactamase inhibitors, as well as carbapenemes, and fluoroquinolones exhibited high antimicrobial activity against both the tested Serratia marcescens and non-marcescens isolates. Our study adds useful information regarding the characteristics and outcomes of patients with Serratia infection, as well as the susceptibilities of the respective Serratia marcescens and non-marcescens isolates, in a region with relatively high levels of antimicrobial resistance.

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“…In some cases, ESBL-expressing S. marcescens strains have caused outbreaks (94,196,281,284,293). S. marcescens strains most commonly carry CTX-M-type ESBLs (69,196,218,273,284,293,295,414,421) but have also been found carrying SHV (218,281,284,295), TEM (218,284,295), and a novel ESBL, BES-1 (42).…”

Section: ␤-Lactam Resistance In Serratia Speciesmentioning

confidence: 99%

Serratia Infections: from Military Experiments to Current Practice

2011

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SUMMARY Serratia species, in particular Serratia marcescens , are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history. The organisms in this genus, particularly S. marcescens , were long thought to be nonpathogenic. Because S. marcescens was thought to be a nonpathogen and is usually red pigmented, the U.S. military conducted experiments that attempted to ascertain the spread of this organism released over large areas. In the process, members of both the public and the military were exposed to S. marcescens , and this was uncovered by the press in the 1970s, leading to U.S. congressional hearings. S. marcescens was found to be a certain human pathogen by the mid-1960s. S. marcescens and S. liquefaciens have been isolated as causative agents of numerous outbreaks and opportunistic infections, and the association of these organisms with point sources such as medical devices and various solutions given to hospitalized patients is striking. Serratia species appear to be common environmental organisms, and this helps to explain the large number of nosocomial infections due to these bacteria. Since many nosocomial infections are caused by multiply antibiotic-resistant strains of S. marcescens , this increases the danger to hospitalized patients, and hospital personnel should be vigilant in preventing nosocomial outbreaks due to this organism. S. marcescens , and probably other species in the genus, carries several antibiotic resistance determinants and is also capable of acquiring resistance genes. S. marcescens and S. liquefaciens are usually identified well in the clinical laboratory, but the other species are rare enough that laboratory technologists may not recognize them. 16S rRNA gene sequencing may enable better identification of some of the less common Serratia species.

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CTX-M and TEM as Predominant Types of Extended Spectrum β-Lactamases Among Serratia marcescens Isolated From Solid Organ Recipients

Cited by 9 publications

References 7 publications

Molecular Analysis of Carbapenem-resistant Strains of Pseudomonas aeruginosa Isolated From Patients Hospitalized in Various Transplantation Wards Between 2008 and 2011

Molecular Analysis of Carbapenem-resistant Strains of Pseudomonas aeruginosa Isolated From Patients Hospitalized in Various Transplantation Wards Between 2008 and 2011

Serratia infections in a general hospital: characteristics and outcomes

Serratia Infections: from Military Experiments to Current Practice

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