Serratia infections in a general hospital: characteristics and outcomes

Samonis, George; Vouloumanou, Evridiki K.; Christofaki, Maria; Dimopoulou, Dimitra; Maraki, Sofia; Triantafyllou, E.; Kofteridis, Diamantis P.; Falagas, Matthew E.

doi:10.1007/s10096-010-1135-4

Cited by 32 publications

(22 citation statements)

References 47 publications

(50 reference statements)

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“…Review of the three deaths recorded in this study by the attending clinician revealed that these deaths were likely attributed to infection with S. liquefaciens. In 2011, a study conducted in Greece made a similar fatal case report [13]. Again, our findings corroborate those of a report of a 10-year population-based study in Canberra, Australia, which showed Serratia species bacteremia to be more common than what was known, with a high proportion (47%) of episodes [27].…”

Section: Discussionsupporting

confidence: 86%

“…Occasionally, S. liquefaciens is isolated from clinical specimens but its pathogenic role is often unclear [6]. S. liquefaciens causes infections in immunocompromised hosts [13], such as neonates [26], and in those with indwelling/introduced foreign bodies/liquids, e.g., intravenous/intra-arterial (IV/IA) lines, endotracheal tubes, multiple use vials [16]; thus, the entry routes are ingestion, injection, and catheterization. Our investigation of an outbreak of S. liquefaciens infection in a rural African health center revealed expected sources and modes of transmission; various solutions used in patient care were contaminated and there was poor practice in the use of these solutions.…”

Section: Discussionmentioning

confidence: 99%

“…It is a highly motile organism with swarming capacity and is commonly found in water, soil, plants, and insects [11]. The pathogenicity of S. liquefaciens is well established in humans, insects, and fish [11][12], and cases of fatal infection have been reported [13]. Many investigations have documented outbreaks of S. liquefaciens in settings of medical care, such as hemodialysis centers and neurosurgery departments [14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Serratia species have been isolated from specimens such as blood, urine, cerebrospinal fluid, sputum, induced sputum, lung aspirate, and wound swabs [11]. High levels of antimicrobial resistance among isolates of S. liquefaciens complicate treatment [13].…”

Section: Introductionmentioning

confidence: 99%

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An outbreak of Serratia liquefaciens at a rural health center in The Gambia

Ikumapayi

Kanteh

Manneh

et al. 2016

J Infect Dev Ctries

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Introduction: Healthcare-associated infections (HAIs) are better documented in developed than in developing countries. There are emerging reports regarding the high frequency of HAIs in developing countries. We aimed to report an outbreak of an HAI caused by Serratia liquefaciens at a rural health center in The Gambia. Methodology: Following an abrupt increase in the isolation of S. liquefaciens in clinical samples, laboratory and clinical consumables, as well as staff, were screened for contamination with S. liquefaciens. Conventional microbiological techniques and biochemical identification tests were used. A phenotypic typing was achieved using the Kirby-Bauer antibiotic susceptibility method. Strategies to control the outbreak were implemented. Results: A total of 794 samples were processed during the outbreak; 44 (6%) grew S. liquefaciens. Five (25%) of the 20 suspected contaminated materials (hospital consumables and equipment) screened yielded growth of the organism. The primary source of the outbreak was hospital consumables. Three (7%) of the 44 infected children died with no other known cause than S. liquefaciens infection. Ninety-nine percent similarity of the antibiogram phenotypic typing suggests the isolates were from the same clonal origin. The outbreak was successfully controlled after the removal and sterilization of the respective contaminated fluids and equipment. Conclusions: This HAI was caused by poor practice in the preparation of medications for nebulization and intravenous infusion, hygiene practices, and a lack of awareness among staff about infection control. We recommend further studies to delineate the role played by HAIs in the developing world.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An outbreak of Serratia liquefaciens at a rural health center in The Gambia

Ikumapayi

Kanteh

Manneh

et al. 2016

J Infect Dev Ctries

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“…Se ha descrito como agente causal de infecciones del tracto respiratorio, urinario, de úlceras o heridas. Se ha aislado en piel, excrementos, bilis y sangre [1][2][3][4][5][6][7][8] . Su identificación es relativamente sencilla usando los métodos de identificación comerciales.…”

Section: Discussionunclassified

Bacteriemia por Serratia rubidaea con fenotipo atípico de resistencia a quinolonas

Gentille

Pérez

Centelles

2014

Rev. chil. infectol.

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Endogenous endophthalmitis due to Serratia marcescens secondary to late‐onset empyema Post‐Cardiac surgery in an End‐Stage renal disease patient on peritoneal dialysis

Sasi

Faraj

Barazi

et al. 2023

Clinical Case Reports

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Endogenous bacterial endophthalmitis results from bacterial seeding of the eye during bacteremia. A diagnosis of endogenous bacterial endophthalmitis requires clinical findings such as vitritis or hypopyon along with positive blood cultures. Serratia marcescens is the second most common pathogen causing hospital‐acquired ocular infections. This report describes a case of endogenous bacterial endophthalmitis caused by S. marcescens in an older adult with end‐stage renal disease (ESRD) on peritoneal dialysis, who had late‐onset pleural empyema secondary to coronary artery bypass grafting (CABG). A 61‐year‐old gentleman presented with a two‐day history of cloudy vision, black floaters, pain, swelling, and gradual vision loss in his right eye. There was no history of trauma, ocular surgeries, or previous similar episodes. He had myocardial infarction treated with CABG 3 months back. Examination showed a 3 mm hypopyon in the anterior chamber. He had classic signs of endophthalmitis with positive blood cultures for S. marcescens. He was treated with high‐dose intravenous meropenem and intravitreal ceftazidime without vitrectomy. Endophthalmitis progressed to complete vision loss in his right eye, requiring evisceration. Endophthalmitis caused by S. marcescens is rare, but long‐term outcomes can be severe, causing complete vision loss in about 60% of the patients. It is usually hospital‐acquired, and the source can be late‐onset empyema several months after cardiac surgery, in an immunocompromised patient. Systemic antibiotics should be supplemented with intravitreal agents with or without pars plana vitrectomy.

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Serratia infections in a general hospital: characteristics and outcomes

Cited by 32 publications

References 47 publications

An outbreak of Serratia liquefaciens at a rural health center in The Gambia

An outbreak of Serratia liquefaciens at a rural health center in The Gambia

Bacteriemia por Serratia rubidaea con fenotipo atípico de resistencia a quinolonas

Endogenous endophthalmitis due to Serratia marcescens secondary to late‐onset empyema Post‐Cardiac surgery in an End‐Stage renal disease patient on peritoneal dialysis

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