CT Perfusion in the Treatment of a Swine Model of Unilateral Renal Artery Stenosis: Validation with Microspheres

Paul, Russell K.; Lum, Darren P.; Consigny, Daniel W.; Grinde, J.; Grist, Thomas M.

doi:10.1016/j.jvir.2008.12.420

Cited by 4 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[52][53][54] It already has been used in various animal models previously to assess the validity of other blood flow measurement techniques, such as magnetic resonance (MR), 28 positron emission tomography (PET), 27 computed tomography (CT), 29 as well as ultrasound perfusion imaging techniques, 31 laser Doppler velocimetry, 26,30 and LSFG. 43,55 In this study, we found an excellent agreement of TRBF measurements assessed with dual-beam Doppler OCT and the microsphere method.…”

Section: Discussionmentioning

confidence: 99%

Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

Told

Wang

Cull

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Told R, Wang L , Cull G, et al. Total retinal blood flow in a nonhuman primate optic nerve transection model using dual-beam bidirectional Doppler FD-OCT and microsphere method. Invest Ophthalmol Vis Sci. 2016;57:143257: -144057: . DOI:10.1167 PURPOSE. We validated noninvasive Doppler-optical coherence tomography (OCT) blood flow measurements against the terminal microsphere method in a surgical induced optic nerve transection nonhuman primate model. METHODS.In 6 nonhuman primates, total retinal blood flow (TRBF) was measured with a custom-built dual-beam bidirectional Doppler Fourier Domain (FD)-OCT. Peripapillary retinal nerve fiber layer thickness (RNFLT) was measured by Spectralis spectral-domain (SD)-OCT. Measurements were performed every 10 to 15 days before and after unilateral optic nerve transection (ONT) until RNFLT was reduced by more than 40% from baseline. Before the animals were killed, TRBF was measured using the microsphere technique. RESULTS.A significant correlation between all arterial and venous Doppler OCT TRBF measurements was found in ONT and contralateral control eyes (both P < 0.01, n ¼ 6). The Bland-Altman analysis showed a bias of 0.57 in the ONT group and 0.02 in the contralateral control group. Also, excellent agreement was observed between Doppler OCT and microsphere measurements (P < 0.01, r ¼ 0.976, bias ¼ 0.54). After ONT, TRBF and RNFLT decreased by À51% 6 42% and À44% 6 2% (n ¼ 5), respectively. In the contralateral control eyes, TRBF and RNFLT were unchanged.CONCLUSIONS. Very good accordance was found between TRBF measurements, obtained with dual-beam bidirectional Doppler FD-OCT and the microsphere method. It also was possible to monitor changes over time in TRBF after ONT with Doppler OCT. These findings highlight the accuracy and potential of noninvasive Doppler OCT to provide valuable information for detecting early changes in ocular disease in future.

show abstract

Section: Discussionmentioning

confidence: 99%

Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

Told

Wang

Cull

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Our study had a number of limitations. First, DCE CT perfusion with the maximum slope method is not a strong reference standard, although it has been validated in many previous studies (16,17). Second, the contrast material injection duration longer than that of a typical maximum slope CT perfusion protocol may have led to slight underestimation of perfusion.…”

Section: Technical Developments: Whole-organ Ct Perfusion Technique Wmentioning

confidence: 99%

A Simplified Whole-Organ CT Perfusion Technique with Biphasic Acquisition: Preliminary Investigation of Accuracy and Protocol Feasibility in Kidneys

et al. 2016

View full text Add to dashboard Cite

show abstract

Use of Dual-Source Computed Tomography to Evaluate Renal Cortical Perfusion in Patients With Essential Hypertension Without Diabetes

Chen

Wang²,

Sun³

et al. 2015

Journal of Computer Assisted Tomography

View full text Add to dashboard Cite

show abstract

CT Perfusion in the Treatment of a Swine Model of Unilateral Renal Artery Stenosis: Validation with Microspheres

Cited by 4 publications

References 42 publications

Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

A Simplified Whole-Organ CT Perfusion Technique with Biphasic Acquisition: Preliminary Investigation of Accuracy and Protocol Feasibility in Kidneys

Use of Dual-Source Computed Tomography to Evaluate Renal Cortical Perfusion in Patients With Essential Hypertension Without Diabetes

Contact Info

Product

Resources

About