Use of Dual-Source Computed Tomography to Evaluate Renal Cortical Perfusion in Patients With Essential Hypertension Without Diabetes

Chen, Jia; Wang, Zhaoqian; Sun, Xiaochuan; Yang, Zhiqiang; Cheng, Yunpeng

doi:10.1097/rct.0000000000000230

Cited by 1 publication

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References 27 publications

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“…In line with our findings, Jia et al . reported lower cortical blood flow in essential HT than in healthy controls using dynamic 4D spiral scanning [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasonography reveals a lower cortical perfusion and a decreased renal flow reserve in hypertensive patients

Damianaki

Hendriks-Balk

Brito

et al. 2023

Nephrology Dialysis Transplantation

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Background Microvascular structural alteration and dysfunction is a hallmark of arterial hypertension. So far, the visualization and the quantification of renal microcirculation in humans has been hampered by the lack of non-nephrotoxic and non-invasive radiologic techniques. Contrast-Enhanced ultrasonography (CEUS) is an alluring method to investigate renal microcirculation and has not been investigated in this setting. We aimed to compare renal microcirculation in normotensives (NT) and hypertensive (HT) participants using CEUS at rest and during a sympathetic stress test. Methods We measured the renal perfusion index (PI, primary outcome), the renal resistive index (RRI), beat-to-beat systemic hemodynamics and plasma catecholamines before and during a 2-minute cold pressor test (CPT) in NT and HT participants. Linear mixed model analysis was used to compare the effect of the CPT on the variables of interest. Results 73 participants (32 HT) with normal kidney function were included. HT participants had a lower baseline PI compared to NT participants [1476(959–2155) arbitrary unit (a.u.) vs 2062(1438–3318) a.u., p < 0.001]. The CPT increased blood pressure, heart rate and catecholamines in all participants. The increase in PI observed in NT during the CPT was blunted in HT (+504(117–920) a.u. vs + 1159(678–2352) a.u in NT, interaction p = 0.013). Age, sex and body mass index did not modify these results. Conclusions HT patients had a lower basal renal cortical perfusion. During the cold pressor test, HT participants had a smaller increase in the PI, suggesting that renal cortical flow reserve is impaired.

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“…In line with our findings, Jia et al . reported lower cortical blood flow in essential HT than in healthy controls using dynamic 4D spiral scanning [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasonography reveals a lower cortical perfusion and a decreased renal flow reserve in hypertensive patients

Damianaki

Hendriks-Balk

Brito

et al. 2023

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

show abstract

Use of Dual-Source Computed Tomography to Evaluate Renal Cortical Perfusion in Patients With Essential Hypertension Without Diabetes

Abstract: Essential hypertension, especially EH-related TOD, alters renal cortical perfusion parameters, especially BF. Four-dimensional spiral CT renal perfusion examination showed that duration of hypertension, eGFR, and BMI were independently associated with decreased BF.

Cited by 1 publication

References 27 publications

Contrast-enhanced ultrasonography reveals a lower cortical perfusion and a decreased renal flow reserve in hypertensive patients

Contrast-enhanced ultrasonography reveals a lower cortical perfusion and a decreased renal flow reserve in hypertensive patients

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