CT Patterns of Nodular Hepatic and Splenic Sarcoidosis: A Review of the Literature

Scott, George C.; Berman, Joel M.; Higgins, Joseph L.

doi:10.1097/00004728-199705000-00006

Cited by 64 publications

(33 citation statements)

References 11 publications

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“…Splenic involvement is conrmed in 24 to 59z of patients by biopsy 7,8 and in 38 to 77z of patients by autopsy, 9 and one previous study showed splenic lesions in 69z of patients with hepatic sarcoidosis. 10 Hepatosplenic sarcoidosis most commonly manifests as organomegaly. 11 Five to 15z of patients have multiple nodules in the liver and spleen observable on MR imaging (Fig.…”

Section: Hepatosplenic Sarcoidosismentioning

confidence: 99%

Hepatosplenic and Muscular Sarcoidosis: Characterization with MR Imaging

Sekine¹,

Amano²,

Hidaka³

et al. 2012

MRMS

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Sarcoidosis is a multisystem disorder of unknown etiology that involves multiple organs. Computed tomography is theˆrst-line imaging modality for diagnosing sarcoidosis because of its capacity to detect hilar lymphadenopathy and pulmonary lesions. Magnetic resonance (MR) imaging provides good soft tissue contrast that is useful for detecting sarcoidosis in some body parts, including skeletal muscle. Signal intensity on pre-and postcontrast T 1 -and T 2 -weighted imaging may re‰ect disease activity and the pathological appearance of sarcoidosis. In this review, we demonstrate these conventional MR imaginĝ ndings of hepatosplenic and muscular sarcoidosis and describe the usefulness of diŠusion-weighted imaging for detecting sarcoidosis.

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Section: Hepatosplenic Sarcoidosismentioning

confidence: 99%

Hepatosplenic and Muscular Sarcoidosis: Characterization with MR Imaging

Sekine¹,

Amano²,

Hidaka³

et al. 2012

MRMS

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“…In a biopsy-proven study of 49 patients, LAP in 20 of the cases, splenomegaly in 16 of them, hepatomegaly in two and hypodens nodular lesions in spleen and liver in seven of the patients were reported (11). In a review consisted of 20 patients who had splenic and hepatic hypodense lesions, isolated splenic spread is in seven patients, isolated hepatic spread is in 4 and both hepatic and splenic spread simultaneously was seen in nine patients (12). Multiple hepatic and splenic involvement of sarcoidosis in 39 cases and isolated splenic involvement were reported in only three cases in English literature (5).…”

Section: Discussionmentioning

confidence: 99%

Nodular Splenic Sarcoidosis: A Rare Case Report

Çalık¹,

Yesildag²,

Calik³

et al. 2017

Respir Case Rep

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Sarcoidosis is an idiopathic, multi-systemic, granulomatous disease. It most commonly involves the lungs. Herein, we present a rare and usually asymptomatic case with splenic sarcoidosis without liver involvement. A 31-year-old male patient was admitted to our clinic with cough, sputum, and shortness of breath. He reported no common systemic complaints of sarcoidosis. Thoracic and abdominal computed tomography showed multiple hypodense mediastinal lymph nodes with splenic involvement. No other intra-abdominal pathology or peripheral lymphadenopathy was detected. Mediastinoscopy was performed. Diagnosis was made histopathologically. Following the treatment, his complaints regressed. Nodular splenic involvements are uncommon. Although there have been reported thirty-nine cases of sarcoidosis with multiple nodular hepatic and splenic lesions, only three isolated splenic cases have been reported in the literature to date. Despite its rarity, extra-pulmonary sarcoidosis may cause significant morbidity and mortality. Therefore, we discuss this case to draw attention to splenic sarcoidosis without liver involvement and its manifestations, diagnosis, and clinical course.

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“…In spite of frequent hepatosplenic involvement, abdominal imaging studies usually show only a nonspecific heterogeneous hepatosplenomegaly. The presence of nodules in the liver and spleen on sonography and CT is unusual 4,6,[8][9][10] and has been reported in only 5% of hepatic sarcoidoses and 15% of splenic sarcoidosis. 10,11 The detection of hepatic or splenic focal lesions, as in our case, triggers a wider differential diagnosis that includes other conditions such as metastatic disease and lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Splenic focal lesions as manifestation of sarcoidosis: Characterization with contrast‐enhanced sonography

Pérez-Grueso

Repiso

Gómez

et al. 2007

J of Clinical Ultrasound

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We report the case of a 74-year-old woman with elevated liver enzyme levels in whom abdominal sonographic examination revealed a diffusely heterogeneous liver parenchyma and multiple hypoechoic subcentimetric splenic nodules. Contrast-enhanced sonography (CEUS) revealed that the splenic focal lesions did not enhance. CT examination revealed a low-density, multinodular pattern both in the liver and in the spleen. Core biopsy of 1 hepatic nodule revealed noncaseating epithelioid cell granuloma, and the patient was diagnosed with systemic sarcoidosis. CEUS has shown to be useful in the diagnosis of focal hepatic lesions, but studies referring to splenic lesions are lacking.

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CT Patterns of Nodular Hepatic and Splenic Sarcoidosis: A Review of the Literature

Abstract: We conclude that increased awareness and recognition of these patterns of nodular hepatic/splenic sarcoidosis on CT will greatly improve detection and diagnosis of abdominal sarcoidosis.

Cited by 64 publications

References 11 publications

Hepatosplenic and Muscular Sarcoidosis: Characterization with MR Imaging

Hepatosplenic and Muscular Sarcoidosis: Characterization with MR Imaging

Nodular Splenic Sarcoidosis: A Rare Case Report

Splenic focal lesions as manifestation of sarcoidosis: Characterization with contrast‐enhanced sonography

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