CT assessment of the effect of fluticasone propionate aqueous nasal spray treatment on lower turbinate hypertrophy due to vasomotor rhinitis

Abstract

Treatment with FP provided significantly greater relief from the symptom of nasal obstruction compared with placebo over the entire 3-month treatment period (p < 0.001). When the change from baseline was compared between the two groups, FP produced statistically significant reductions in the mucosal area of the lower turbinates and in the thickness of the nasal mucosa after 3 months (p < 0.05).

Medical treatment of adenoid hypertrophy with “fluticasone propionate nasal drops”

“…These results suggest that the improvement in nasal airway obstruction symptoms is related to the effect of intranasal corticosteroids on adenoid size. On the other hand, it should also be taken into consideration that the use of fluticasone propionate increases the nasal airway and additionally enables improvement of symptoms by reducing soft tissues of the inferior turbinate [17]. Regarding the usage of intranasal steroids, which dosage and which position should be used is still a matter of debate.…”

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

“…These drugs are effective even in patients with severe allergic rhinitis; their effects are clearly observable, and many patients obtain excellent results. INS are effective for the treatment of nasal obstruction that is unresponsive to H1-receptor antagonists, for aiding withdrawal from vasoconstrictive nose drops (a-sympathetic stimulants) and for the treatment of vasomotor rhinitis [80].…”

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

“…Auch Messungen der Herzfrequenz zeigten eine relative parasympathische Hyperaktivit ä t [302] . Basierend auf standardisierten Frageb ö gen haben Beschwerdefreiheit im Fr ü hling und in Anwesenheit von Katzen, fehlende allergische Erkrankung der Eltern, Symptome bei Parf ü men und D ü ften und das Alter bei Erstmanifestation einen pr ä dikativen Wert f ü r das Vorliegen einer vasomotorischen Rhinitis [303] Topische Antihistaminika [304] , Glukokortikoide [305] und Ipatropiumbromid sind eff ektiv in der Behandlung der vasomotorischen Rhinitis [298] . Allerdings zeigte sich f ü r Fluticason in einer Subgruppe, deren Trigger Wind und Temperaturwechsel waren, kein Therapieeff ekt [306] .…”