Crystalline Zeolite Layers on the Surface of Titanium Alloys in Biomedical Applications: Current Knowledge and Possible Directions of Development

Jakubowski, Marcel; Voelkel, Adam; Sandomierski, Mariusz

doi:10.3390/cryst12111520

Cited by 7 publications

(5 citation statements)

References 61 publications

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“…SLM operates under an inert atmosphere, whereas EBM operates under a vacuum, affecting the final product’s overall characteristics [ 118 ]. Various strategies, such as coating, surface modification, drug loading, etc., have been employed to achieve antimicrobial capabilities in the implants [ 119 ]. Since coatings have already been discussed in the previous sections, the various surface modifications, 3D printing, and design strategies used to develop anti-microbial 3D printed implants are discussed in this section.…”

Section: Antimicrobial 3d Printed Titanium Implantsmentioning

confidence: 99%

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

et al. 2022

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Titanium and its alloys are widely used as implant materials for biomedical devices owing to their high mechanical strength, biocompatibility, and corrosion resistance. However, there is a significant rise in implant-associated infections (IAIs) leading to revision surgeries, which are more complicated than the original replacement surgery. To reduce the risk of infections, numerous antibacterial agents, e.g., bioactive compounds, metal ions, nanoparticles, antimicrobial peptides, polymers, etc., have been incorporated on the surface of the titanium implant. Various coating methods and surface modification techniques, e.g., micro-arc oxidation (MAO), layer-by-layer (LbL) assembly, plasma electrolytic oxidation (PEO), anodization, magnetron sputtering, and spin coating, are exploited in the race to create a biocompatible, antibacterial titanium implant surface that can simultaneously promote tissue integration around the implant. The nature and surface morphology of implant coatings play an important role in bacterial inhibition and drug delivery. Surface modification of titanium implants with nanostructured materials, such as titanium nanotubes, enhances bone regeneration. Antimicrobial peptides loaded with antibiotics help to achieve sustained drug release and reduce the risk of antibiotic resistance. Additive manufacturing of patient-specific porous titanium implants will have a clear future direction in the development of antimicrobial titanium implants. In this review, a brief overview of the different types of coatings that are used to prevent implant-associated infections and the applications of 3D printing in the development of antibacterial titanium implants is presented.

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Section: Antimicrobial 3d Printed Titanium Implantsmentioning

confidence: 99%

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

et al. 2022

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“…This prevents the secretion of too much of the active substance in too short a time, thanks to which the maximum safe concentration will not be exceeded, and at the same time it will not cause a toxic effect. In addition, the desorbing of the substance from the zeolites over a long period of time due to ion exchange indicates the potential for the use of the carriers in the treatment of osteoporosis (e.g., from zeolite-modified titanium implants 42 ), where the delivery of small doses of the drug is desirable. The desorption of EGCG under acidic conditions (pH 5) proceeded in a different way than the release under the influence of simulated body fluids.…”

Section: Resultsmentioning

confidence: 99%

Zeolites with Divalent Ions as Carriers in the Delivery of Epigallocatechin Gallate

Sandomierski

Chojnacka

Ratajczak

et al. 2023

ACS Biomater. Sci. Eng.

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Epigallocatechin gallate (EGCG) is a compound with very high therapeutic potential in the treatment of osteoporosis and cancer. The disadvantages of this compound are its low stability and low bioavailability. Therefore, carriers for EGCG are sought to increase its use. In this work, new carriers are proposed, i.e., zeolites containing divalent ions of magnesium, calcium, strontium, and zinc in their structure. EGCG is retained on the carrier surface by strong interactions with divalent ions. Due to the presence of strong interactions, EGCG is released in a controlled manner from the carrier-ion-EGCG drug delivery system. The results obtained in this work confirm the effectiveness of the preparation of new carriers. EGCG is released from the carriers depending on the pH; hence, it can be used both in osteoporosis and in the treatment of cancer. The divalent ion used affects the sorption and release of the drug. The obtained results indicate the great potential of the proposed carriers and their advantage over the carriers described in the literature.

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“… Changes in the physicochemical properties of zeolites as a function of the molar ratio of silicon to aluminum (own elaboration based on Payra, Dutta [ 24 ]; Jakubowski et al [ 31 ]). …”

Section: Properties and Classification Of Zeolitesmentioning

confidence: 99%

Zeolite Properties, Methods of Synthesis, and Selected Applications

Kordala,

Wyszkowski

2024

Molecules

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Zeolites, a group of minerals with unique properties, have been known for more than 250 years. However, it was the development of methods for hydrothermal synthesis of zeolites and their large-scale industrial applications (oil processing, agriculture, production of detergents and building materials, water treatment processes, etc.) that made them one of the most important materials of the 20th century, with great practical and research significance. The orderly, homogeneous crystalline and porous structure of zeolites, their susceptibility to various modifications, and their useful physicochemical properties contribute to the continuous expansion of their practical applications in both large-volume processes (ion exchange, adsorption, separation of mixture components, catalysis) and specialized ones (sensors). The following review of the knowledge available in the literature on zeolites aims to present the most important information on the properties, synthesis methods, and selected applications of this group of aluminosilicates. Special attention is given to the use of zeolites in agriculture and environmental protection.

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Crystalline Zeolite Layers on the Surface of Titanium Alloys in Biomedical Applications: Current Knowledge and Possible Directions of Development

Cited by 7 publications

References 61 publications

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives

Zeolites with Divalent Ions as Carriers in the Delivery of Epigallocatechin Gallate

Zeolite Properties, Methods of Synthesis, and Selected Applications

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