Zeolites with Divalent Ions as Carriers in the Delivery of Epigallocatechin Gallate

Abstract

Epigallocatechin gallate (EGCG) is a compound with very high therapeutic potential in the treatment of osteoporosis and cancer. The disadvantages of this compound are its low stability and low bioavailability. Therefore, carriers for EGCG are sought to increase its use. In this work, new carriers are proposed, i.e., zeolites containing divalent ions of magnesium, calcium, strontium, and zinc in their structure. EGCG is retained on the carrier surface by strong interactions with divalent ions. Due to the presence of strong interactions, EGCG is released in a controlled manner from the carrier-ion-EGCG drug delivery system. The results obtained in this work confirm the effectiveness of the preparation of new carriers. EGCG is released from the carriers depending on the pH; hence, it can be used both in osteoporosis and in the treatment of cancer. The divalent ion used affects the sorption and release of the drug. The obtained results indicate the great potential of the proposed carriers and their advantage over the carriers described in the literature.

Characterization of a Zeolite-Y-Encapsulated Zn(II)Salmphen Complex with Targeted Anticancer Property

“…Due to their structural properties, biocompatibility, and stability in biological environments, these porous materials have numerous applications in biology as an active ingredient as well as a drug carrier. − It is observed that when both the zeolite and a drug are administered simultaneously to a patient, the pharmacological effect of the drug is not lost. It has been shown that the encapsulation of some hydrophobic chemotherapeutic medicines such as 5-fluorouracil, temozolomide, and α-cyano-4-hydroxy-cinnamic acid in various zeolite structures enhanced the action of drug molecules in biological system. ,,− Even the internalization of various zeolite moieties within cancer cells was found to be faster than the normal cell lines. − Encapsulation of different transition-metal complexes with molecular dimensions comparable to the diameter of zeolitic cavities has been immensely endeavored and numerous applications have been accentuated. − A copper Schiff base complex encapsulated inside zeolite-Y was screened for its cytotoxic activity. Interestingly, in comparison to cisplatin, a zeolite-Y-encapsulated Cu­(II)­hydrazone complex has shown a superior therapeutic effect in HePG2 cells (human liver cancer).…”