Characterization of a Zeolite-Y-Encapsulated Zn(II)Salmphen Complex with Targeted Anticancer Property

Synthesis and Characterization of Zn-Salophen Complexes with Different D–A Distances: An Approach to Tuning the Intersystem-Crossing Process

“…Metallosalen/salophen (bis(salicylidene)ethylenediamine and bis(salicylidene)phenyldiamine) complexes have attracted considerable attention due to their versatile applications in catalysis [1][2][3][4][5][6][7][8][9][10], supramolecular chemistry [11][12][13][14][15][16][17][18], optical materials [19][20][21], and biological sensors or therapeutics [22,23] because of their rich chemistry and ease of manipulation of organic ligands. Among these complexes, zinc (II) salen/salophen complexes are of particular interest due to the non-redox nature and d 10 closed-shell configuration of the Zn 2+ ion, making them suitable for ligand-dependent fluorescent materials [24]. However, very few Zn-salen/salophen complexes have been found to generate reactive oxygen species (ROS), a capability which is essential to expanding their scope beyond fluorescence imaging to theranostics, a growing field of biomedical materials that combines imaging with therapeutics.…”

“…Although charge transfer has been found in salophen complexes of various metals [25], currently only Saumi Ray et al have synthesized zinc complexes with m-phenylenediamine and salicylaldehyde and found the presence of charge transfer. Cell experiments have demonstrated the production of ROS; compared with empty ligands, Zn complexes have a stronger ability to produce ROS [24]. This is due to the relatively weaker "heavy atom effect" associated with the zinc ion, resulting from the less pronounced spin-orbital coupling of this ion compared with the second and third transition metals.…”