Crystalline and Macrocrystalline Nitrofurantoin in the Treatment of Urinary-Tract Infection

Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials

“…Two of the earliest trials assessed compared nitrofurantoin monohydrate with macrocrystalline nitrofurantoin for occurrence of side effects. 23,24 Both studies demonstrated a roughly 50% reduction in the occurrence of gastrointestinal side effects with the macrocrystalline formulation, with comparable microbiological efficacy. The clinical trials following these two studies used a macrocrystalline formulation.…”

Synthesis, structure and biological activity of copper(II) complexes with oxolinic acid

“…1b), a first-generation quinolone antimicrobial drug, is known for its antibacterial activity, which is the treatment of urinary tract infections [29][30][31][32][33][34][35][36][37]. Being a typical 4-quinolone, oxolinic acid is expected to act as a bidentate ligand coordinated through the pyridone oxygen and one carboxylate oxygen atoms [17].…”

Drugs Causing Crystalline Retinopathy: Pathogenesis, Diagnosis, and Treatment (Tamoxifen, Canthaxanthin, Methoxyflurane, Nitrofurantoin, Talc)

“…Tanı, oftalmoskopide kristal birikintilerin bulunmasına ve genellikle tekrarlayan idrar yolu enfeksiyonları için profilaksi ile ilişkili uzun süreli nitrofurantoin kullanım öyküsüne dayanır. [46] Oftalmik değerlendirme, retina periferi korunarak arka kutup boyunca sirsinat bir paternde iki taraflı yüzeysel ve derin retina içi parlak kristal birikintileri izlenir. İdrar tahlilinde kristalüri gösterilebilir.…”