To establish the safety and efficacy of low-dose oral methotrexate in treating refractory interstitial cystitis, 9 women who fulfilled internationally accepted criteria for the diagnosis of interstitial cystitis were enrolled in a prospective study. All had proven unresponsive to conventional treatment modalities. Assessment by pain score and frequency volume charts was performed pretreatment and up to 6 months during therapy. No significant adverse side effects were noted. At the end of follow-up, 4 women had noted a subjective improvement in bladder pain and wished to continue on methotrexate, 4 women noted little change and 1 woman reported a worsening of symptoms. Overall there was a significant reduction in pain score (p = 0.047) posttreatment. However, there was no significant difference in urinary frequency per 24 hours (p = 0.40), maximum voided volume (p = 0.089) or mean voided volume (p = 0.59). Methotrexate significantly improved bladder pain in women with interstitial cystitis, although no significant change was found in voiding pattern.
Captopril‐induced agranulocytosis in systemic sclerosis. M. A. Watson, N. J. Radford, B. P. McGrath, G. W. Swinton and J. W. M. Agar, Aust. N.Z. J. Med., 1981, 11, pp. 79–81.
A 25 year old woman with systemic sclerosis developed severe but reversible agranulocytosis seven weeks after commencing treatment with Captopril for severe hypertension and renal impairment
The evidence suggests that the agranulocytosis was caused by Captopril
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