Crystal structure of tetraaquabis(1,3-dimethyl-2,6-dioxo-7H-purin-7-ido-κN7)cobalt(II)

Hamdani, Hicham El; Amane, M. El; Duhayon, Carine

doi:10.1107/s2056989017011379

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…Theophylline transition metal complexes can serve as model compounds to study the relationship between metal ions and nucleic acid oxo purine bases [18][19][20][21][22]. Theophylline functions as a monodentate ligand in a neutral or fundamental environment and coordinates to metal ions through N7 atom [23][24][25][26][27]. In some instances, it functions as a bidentate N(7)/O(6) chelating ligand or as a bridging ligand with N(7)/O(6) chelation and N(9) coordination simultaneously [28,29].…”

Section: Introductionmentioning

confidence: 99%

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Ismail¹,

Al-Bairmani²,

Abbas³

et al. 2020

Nano BioMed ENG

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Three nanocomplexes of Cu(II), Co(II), and Ni(II) with theophylline were synthesized by ultrasonic sonication method. This method was used to produce smaller and narrow-distributed nanoparticles without any aggregations. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR) and elemental analysis (C, H, N, and S) were used to identify and to suggest the structure of the synthesized nanocomplexes. The transmission electron microscopy (TEM) results exhibited that the size of nanocomplexes was in the range of 15-25 nm. The efficacy of the synthesized nanocomplexes was examined against four types of bacterial strains, Staphylococcus aureus, Bacillus subtilis (gram-positive bacteria), and Klebsiella pneumoniae, Escherichia Coli (gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as they resulted in an inhibition zone between 98% and 100%. The copper nanocomplex gave the highest inhibition zone by 100% for each type of bacterial strains, due to the surface plasmon. Therefore, a further test for the copper nanocomplex Cu(THP) 2 (H 2 O) 2 (Cl) 2 was carried out on skin injuries of laboratory mice after it was converted into cream with vaseline and was found to have a very potent influence in healing skin injuries.

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Section: Introductionmentioning

confidence: 99%

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Ismail¹,

Al-Bairmani²,

Abbas³

et al. 2020

Nano BioMed ENG

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“…Theophylline functions as a monodentate ligand in a neutral or fundamental environment and coordinates metal ions through N 7 atoms [19][20][21]. In some instances, it functions as a bidentate N(7)/O(6) chelating ligand or as a bridging ligand with N(7)/O(6) chelation and N(9) coordination simultaneously [22]. The aim of this study was to report the synthesis and characterization of Zn(II), Mn(II) and Fe(II) nanocomplexes with theophylline as a ligand for antibacterial applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(II), Mn(II) and Fe(II) Theophylline Complexes in Nanoscale

Ismail¹,

Al-Bairmani²,

Abbas³

et al. 2020

Nano BioMed ENG

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“…In particular, transition metal complexes with drugs have been attracting continuously growing interest [27]. Regrettably, only a limited number of complexes with theophylline have been reported so far [28][29][30][31][32][33][34][35][36]. In most cases, the coordinating atom is N7, while structures that involve N9 and O6 are also described [32,35,36].…”

Section: Introductionmentioning

confidence: 99%

Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline

et al. 2020

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Two metal complexes of theophylline were synthesized. Namely, 1 with the formula [Cu(theop) 2 (H 2 O) 3 ]·2H 2 O and 2, [Zn(theop) 2 ]·H 2 O (where: theop = theophylline ion). Their properties were thoroughly investigated by the elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA) that were augmented by antimicrobial and antioxidant analyses. Their radical scavenging ability (RSA) is notably higher than that of a pure theophylline itself. Similarly to theophylline complexes already studied by us 3, [Mn(theop) 2 (H 2 O) 4 ] 4, [Co(theop) 2 (H 2 O) 4 ] and 5, [Ni(theop) 2 (H 2 O) 4 ]title compounds are inactive against Gram-negative bacteria, but they show moderate or mild activity against Gram-positive rods. The low temperature, single crystal X-ray diffraction technique determines the crystal structure of 1. Its supramolecular crystal topology is affected by the unique, double palindrome water chain that formed by two conserved and a sole coordinated water molecules. Crystal packing arrangements were characterized by fingerprint plots that were derived from the Hirshfeld surfaces (HS), as calculated for all structures in the series 1, 3, 4, 5.

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Crystal structure of tetraaquabis(1,3-dimethyl-2,6-dioxo-7H-purin-7-ido-κN⁷)cobalt(II)

Cited by 8 publications

References 15 publications

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(II), Mn(II) and Fe(II) Theophylline Complexes in Nanoscale

Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline

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