Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline

Abstract

Two metal complexes of theophylline were synthesized. Namely, 1 with the formula [Cu(theop) 2 (H 2 O) 3 ]·2H 2 O and 2, [Zn(theop) 2 ]·H 2 O (where: theop = theophylline ion). Their properties were thoroughly investigated by the elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA) that were augmented by antimicrobial and antioxidant analyses. Their radical scavenging ability (RSA) is notably higher than that of a pure theophylline itself. Similarly to theophylline complexes already studied by us 3, [Mn(theop) 2 (H 2 O) 4 ] 4, [Co(theop) 2 (H 2 O) 4 ] and 5, [Ni(theop) 2 (H 2 O) 4 ]title compounds are inactive against Gram-negative bacteria, but they show moderate or mild activity against Gram-positive rods. The low temperature, single crystal X-ray diffraction technique determines the crystal structure of 1. Its supramolecular crystal topology is affected by the unique, double palindrome water chain that formed by two conserved and a sole coordinated water molecules. Crystal packing arrangements were characterized by fingerprint plots that were derived from the Hirshfeld surfaces (HS), as calculated for all structures in the series 1, 3, 4, 5.

The use of chitosan as an effective carrier of theophylline - an anti-asthmatic drug

“…The amine stretching signal of the THP is observed at 1562 cm −1 [25]. The FTIR absorption band at 1486 cm -1 refers to the stretching of C=C, whereas the absorption band at 1670 cm -1 refers to the C=N of the purine ring [29].…”

Nano-synthesis, spectroscopic characterisation and antibacterial activity of some metal complexes derived from Theophylline

“…All the prepared nanoparticles show empty from any conglomerate, and the dimensions in all synthesised complexes are within the nanoscale (less than 100 nm) which indicates that the kind of nano is particles and zero dimension which is more preferred in preparing nanoscales. The average size was calculated randomly from the figures, as shown in Table (4). [Cu (L) 12…”

“…Research into theophylline complexes shows that the purine base is mostly bonded to the metal ions in the N7 atom [3][4][5][6][7][8], Theophylline is, in a few situations, a bident ligand, where the metal bond to the N7 is complemented by interaction with the O6 atom, which forms N7 / O6 chelation [9,10]. The research on nanotechnology enables the creation of new nanomaterials in a nanoscale below 100 nm [11][12][13][14][15][16][17][18].…”

Iron(III) and Zinc(II) Metal Alkaloid Complexes: Synthesis, Characterization and Biological Activities

“…Various metals are used to form complexes with alkaloids. Amongst them, iron(III) and zinc(II) are the most frequently used metals because of their associated biological properties such as antimicrobial activity [18][19][20][21]. Iron is hydrolyzed by acidic solutions, and its oxychloride is produced by heating to 350 o C. Due to its strong Lewis acid nature, reaction with Lewis bases is common.…”