The new divalent nano metal-complexes of Zn(II), Mn(II), and Fe(II) with new ligand derivate from theophylline were synthesis by ultrasonic sonication method. This method was applied to produce smaller, narrow distributed nanoparticles and without any aggregations. The nanocomplexes and new ligand (L) were diagnosed by different Physico-chemical studies as Analysis of elements (C.H.N), Measuring conductivity, FT-IR spectra, 1H NMR spectra, UV-Vis spectra, flame atomic absorption (FAA), and their microbial activities. The spectroscopic data of the nanocomplexes suggest their 2:1 (L: M) complex structures of Mn(II), Fe(II), and 1:1 (L: M) complex structure of Zn(II). Also, the spectroscopic studies suggested the octahedral structure for Mn(II) and Fe(II) ions and tetrahedral structure for Zn(II) ion. All spectroscopic data propose that new ligand act as a bidentate ligand with its metal ions. The size and morphology of nanocomplexes measured by TEM were in range (14-18) nm. The bacterial activity was checked with the synthesized ligand and nanocomplexes. Activities show that the nano complexes are more promising than their new ligand for microbial activities.
Three nanocomplexes of Cu(II), Co(II), and Ni(II) with theophylline were synthesized by ultrasonic sonication method. This method was used to produce smaller and narrow-distributed nanoparticles without any aggregations. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR) and elemental analysis (C, H, N, and S) were used to identify and to suggest the structure of the synthesized nanocomplexes. The transmission electron microscopy (TEM) results exhibited that the size of nanocomplexes was in the range of 15-25 nm. The efficacy of the synthesized nanocomplexes was examined against four types of bacterial strains, Staphylococcus aureus, Bacillus subtilis (gram-positive bacteria), and Klebsiella pneumoniae, Escherichia Coli (gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as they resulted in an inhibition zone between 98% and 100%. The copper nanocomplex gave the highest inhibition zone by 100% for each type of bacterial strains, due to the surface plasmon. Therefore, a further test for the copper nanocomplex Cu(THP) 2 (H 2 O) 2 (Cl) 2 was carried out on skin injuries of laboratory mice after it was converted into cream with vaseline and was found to have a very potent influence in healing skin injuries.
The novel was assembled by the ultrasonic sonication method of three new ligand-metal nano complexes with Ni(II), Cu(II), and Co(II) of theophylline derivative. This method was used to produce smaller, small distributed nanoparticles and without any aggregations. Molar conductance, FT-IR, 1 HNMR, UV-Vis., solubility, flame atomic absorption, and (C.H.N) elemental analysis were used to describe and to suggest the structure of the new ligand and nanocomplexes. Engagement of all spectroscopic data indicates that the new ligand (L) acts as a bidentate ligand with its metal ions. The molar conductance reveals that the nanocomplexes were non-electrolytes. The size and morphology of nano complexes measured by TEM were in range (12-18) nm.The biological activities of the synthesised metal nano complexes were assayed against four types of bacterial strains, Staphylococcus aureus, Bacillus subtilis (gram-positive bacteria) and Klebsiella pneumonia, Escherichia Coli (gram-negative bacteria). The results show remarkable leverage compared to the parent ligand in the present nano complexes.
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