Crystal Structure, Antioxidant Properties and Characteristics in Aqueous Solutions of the Oxidovanadium(IV) Complex [VO(IDA)phen]·2H₂O

Abstract

A new oxidovanadium(IV) complex was prepared by the reaction of vanadyl acetylacetonate [VO(acac)2], iminodiacetic acid (H2IDA) and 1,10‐phenanthroline (phen) in aqueous solutions. The crystal structure of [VO(IDA)phen]·2H2O was determined by X‐ray diffraction crystallographic analysis. The stability of the title compound in aqueous solution was investigated by using potentiometric titration methods. Moreover, the kinetics of substitution reactions of the VO(IDA) binary complex with 1,10‐phenanthroline were investigated in aqueous solutions. These reactions were monitored spectrophotometrically at 249 nm by using stopped‐flow methods. Kinetic measurements were performed in the 293–308 K temperature range, at different concentrations (0.1–0.5 mM) of the binary complex and at a constant concentration of phen (0.05 mmol/L). Moreover, the antioxidant properties of this complex against superoxide radicals were studied by nitrobluetetrazolium (NBT) and cyclic voltammetry (CV) and the antioxidant properties were also investigated against two organic radicals: the 1,1‐diphenyl‐2‐picrylhydrazyl radical (DPPH·) and the 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) radical (ABTS·+) by using spectrophotometric methods. The results of the antioxidant tests show that VO(IDA)phen scavenges superoxide free radicals as well as organic radicals (ABTS·+ and DPPH·).

Vanadium-protein complex inhibits human adipocyte differentiation through the activation of β-catenin and LKB1/AMPK signaling pathway

“…Actually, vanadium compound has attracted much attention in the past decade due to it is considered as one of the promising antioxidant and antidiabetic agents [ 26 , 37 , 38 , 45 , 46 ]. Several oxidovanadium complexes including [V(O)(oda)(H 2 O) 2 ] ([oda = O(CH 2 COO - ) 2 ]) and [VO(IDA)phen]·2H 2 O were synthesized and characterized [ 45 , 46 ]. Among them, the latter were found to scavenge superoxide free radicals (O 2 ·- ) and organic radicals (ABTS ·+ and DPPH · ) [ 46 ].…”

“…Several oxidovanadium complexes including [V(O)(oda)(H 2 O) 2 ] ([oda = O(CH 2 COO - ) 2 ]) and [VO(IDA)phen]·2H 2 O were synthesized and characterized [ 45 , 46 ]. Among them, the latter were found to scavenge superoxide free radicals (O 2 ·- ) and organic radicals (ABTS ·+ and DPPH · ) [ 46 ]. A novel aminophenol-derivatized nitrilotriacetic acid vanadyl complex, i.e., p-hydroxyl aminophenol derivative (VOphpada), was confirmed to possess high antioxidant activity and low cytotoxicity.…”

“…) and organic radicals (ABTS �+ and DPPH � ) [46]. A novel aminophenol-derivatized nitrilotriacetic acid vanadyl complex, i.e., phydroxyl aminophenol derivative (VOphpada), was confirmed to possess high antioxidant activity and low cytotoxicity.…”

“…Actually, vanadium compound has attracted much attention in the past decade due to it is considered as one of the promising antioxidant and antidiabetic agents [26,37,38,45,46] [45,46]. Among them, the latter were found to scavenge superoxide free radicals (O 2…”

Antioxidant and antidiabetic activities of vanadium‐binding protein and trifuhalol A

“…phen exhibited antioxidant activity due to the complex reacted with DPPH •+ and ABTS • radicals (Pranczk et al, 2015); Oxovanadium complexes had electron or proton transfer capability to possess antioxidant property (Elsayed et al, 2017). Furthermore, the marine brown alga have been found to have antioxidant activity owing to high content of polyphenolic compounds, phlorotannins from Icelandic Fucus vesiculosus or brown alga Ecklonia stolonifera possessed high DPPH and…”