Crystal‐storing histiocytosis and immunocytoma associated with multifocal fibrosclerosis

Garcia, Joseph F.; Sanchez, Emily; Lloret, E; Martin, Jarad; Piris, Miguel Á.

doi:10.1046/j.1365-2559.1998.00531.x

Cited by 49 publications

(29 citation statements)

References 27 publications

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“…Fewer cases have been seen with benign plasmacytosis, as localized tumours in organs such as stomach and in association with multifocal fi brosclerosis [2,3]. The majority of reported cases of plasma cell dyscrasia accompanied by crystal storing histiocytosis had kappa chain as the monoclonal light chain.…”

Section: Discussionmentioning

confidence: 99%

Crystal storing histiocytosis: a rare presentation of plasma cell myeloma

Kar

Dutta

Bhargava

et al. 2008

Indian J Hematol Blood Transfus

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Crystal storing histiocytosis (CSH) is a very rare association with plasma cell dyscrasias. It is presumed to be an intra-lysosomal accumulation of the secreted paraprotein aggregated into crystals and is associated with presence of variable numbers of histiocyte-like cells with phagocytosed crystalline inclusions in the bone marrow and other extramedullary sites Herein we report a case of multiple myeloma associated with CSH with a rapidly downhill clinical course. There was diagnostic confusion at the outset with a histiocytic disorder which was clarifi ed with the use of Immunohistiochemistry along with serum protein electrophoresis and immunofi xation.

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Section: Discussionmentioning

confidence: 99%

Crystal storing histiocytosis: a rare presentation of plasma cell myeloma

Kar

Dutta

Bhargava

et al. 2008

Indian J Hematol Blood Transfus

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“…8 Non-neoplastic conditions occasionally associated with CSH include rheumatoid arthritis 3 and amyloidosis. 9 The current case illustrates the utility of fine-needle aspiration for detection of CSH, leading to discovery of MGUS. Review of the literature revealed only one published case of CSH diagnosed by fine-needle aspiration of the parotid gland 2 and the current case represents the first published case of CSH diagnosed by fine-needle aspiration of the lung, to our knowledge.…”

Section: Discussionmentioning

confidence: 86%

Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration

Todd

Benninghoff

Frauenhoffer

et al. 2009

Diagnostic Cytopathology

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Crystal-storing histiocytosis (CSH) is a rare process most often occurring in conjunction with an underlying hematopoietic neoplasm, usually multiple myeloma or low-grade B-cell lymphoma. We report the first case of pulmonary CSH diagnosed by fine-needle aspiration biopsy. A patient with a history of urothelial carcinoma developed a lung nodule, which was evaluated by fine-needle aspiration biopsy. Cytologic examination revealed macrophages with abundant cytoplasmic crystals diagnostic of CSH. Based on this cytologic interpretation, additional clinical laboratory evaluation was pursued and revealed a previously unknown monoclonal serum protein. CSH must be differentiated from other non-neoplastic and neoplastic lesions and when diagnosed, should trigger a search for an underlying lymphoproliferative disorder.

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“…CSH is an uncommon phenomenon that is usually seen in disorders associated with the expression of monoclonal Ig [1,2,3,4,5,6,7,8,9] and only rarely in nonneoplastic conditions [11,12,13]. CSH associated with extranodal MZL or mucosa-associated lymphoid tissue lymphoma has been reported in a few cases, with the location of the MZL being the parotid gland [22], ocular adnexa [23], lacrimal gland [20], and lung [24,25].…”

Section: Discussionmentioning

confidence: 99%

“…It has frequently been described in association with B cell neoplasms, such as multiple myeloma [1,2,3,4,5], monoclonal gammopathy of undetermined significance [6], lymphoplasmacytic lymphoma [7,8,9] and other low-grade B cell lymphoproliferative disorders [10]. It has also been described in some nonneoplastic conditions [11,12,13], including rheumatoid arthritis [11], amyloidosis [12], and histiocytic accumulations of phagocytosed clofazimine, a drug used to treat lepromatous leprosy [14,15,16]. Furthermore, CSH can occasionally precede a diagnosis of malignancy [1].…”

Section: Introductionmentioning

confidence: 99%

Cytomorphology of Crystal Storing Histiocytosis in the Breast Associated with Lymphoma: A Case Report

Gao

Khalbuss²,

Austin³

2011

Acta Cytologica

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Crystal storing histiocytosis (CSH) is a very rare immunoglobulin (Ig) deposition disorder in which macrophages accumulate light chains or Ig crystalline inclusions. It is frequently associated with lymphoproliferative disorders, but can be seen in some reactive conditions too. This article reports the cytomorphologic, histopathologic, and ancillary study findings of a marginal zone B cell lymphoma of the breast with CSH in a 54-year-old woman. To the best of our knowledge, this is the first report describing CSH in the breast and one of a few reports describing the cytomorphology of CSH. In breast fine-needle aspiration biopsies, CSH can be confused with benign processes such as fat necrosis and histiocytic lesions. Thus, awareness of this rare entity and its frequent association with lymphoproliferative disorders is useful in order to triage a specimen appropriately and exclude the possibility of a lymphoproliferative process.

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Crystal‐storing histiocytosis and immunocytoma associated with multifocal fibrosclerosis

Cited by 49 publications

References 27 publications

Crystal storing histiocytosis: a rare presentation of plasma cell myeloma

Crystal storing histiocytosis: a rare presentation of plasma cell myeloma

Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration

Cytomorphology of Crystal Storing Histiocytosis in the Breast Associated with Lymphoma: A Case Report

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