Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro

Mei, Zhengrong; Zhang, Fangyan; Tao, Liang; Zheng, Wenhua; Cao, Yanshuo; Wang, Zhaohe; Tang, Shu; Kang, Le; Chen, Shao‐Rui; Pi, Rongbiao; Liu, Peiqing

doi:10.1016/j.neulet.2009.01.013

Cited by 82 publications

(43 citation statements)

References 24 publications

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“…In all studies, cognitive impairment was improved and neurological deficits were reduced, suggesting that both tanshinones and despsides were able, even poorly, to pass the BBB and exert their therapeutical effect. Tanshinones, being lipophilic constituents, are administered orally [20] or intraperitoneally [21][22][23][24][25][26][27]. After 10-20 mg/kg, i. p. injections are effective in reducing infarct size, edema, and cell damage in models of cerebral ischemia.…”

Section: Effects Ofmentioning

confidence: 99%

“…After 10-20 mg/kg, i. p. injections are effective in reducing infarct size, edema, and cell damage in models of cerebral ischemia. A single paper [20] is related to an Alzheimerʼs model of memory impairment, and after the administration of 15 mg/kg/day per os, there is an improvement of spatial learning and memory and a decrease in amyloid plaque. Additionally, a nanoformulation based on pegylated-albumin nanoparticles given intravenously, prolongs circulation time and increases plasma concentration compared with the unformulated TIIA.…”

Section: Effects Ofmentioning

confidence: 99%

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Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Bonaccini

Karioti²,

Bergonzi

et al. 2015

Planta Med

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Section: Effects Ofmentioning

confidence: 99%

Section: Effects Ofmentioning

confidence: 99%

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Bonaccini

Karioti²,

Bergonzi

et al. 2015

Planta Med

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“…We also found SBE could destabilize Aβ1-42 oligomers in a higher concentration and time-dependently (data not shown). In addition, it has been reported that cryptotanshinone extracted from SM strongly attenuated amyloid plaque deposition in transgenic mice and decreased Aβ generation in vitro Mei et al, 2009). We found that SBE destabilized Aβ1-40 oligomers at a similar level with cryptotanshinone in ThT fluorescence assay (data not shown).…”

Section: Discussionmentioning

confidence: 52%

“…For AD, some components of SM such as hydrotanshinone and cryptotanshinone have been reported to have potential therapeutic effects as inhibitors of acetylcholinesterase in vitro (Ren et al, 2004;Lin et al, 2008). In addition, it had been reported that cryptotanshinone attenuated amyloid plaque deposition in the brain of transgenic mouse and decreased Aβ generation in rat cortical neuronal cells overexpressing human APP Mei et al, 2009 Figure 1) (Zheng et al, 2007;Han et al, 2009). Salvianic acid A and borneol are main components of SM and borneol, respectively.…”

Section: Research Articlementioning

confidence: 99%

Salvianic borneol ester reduces β-amyloid oligomers and prevents cytotoxicity

Han

Liu

Zhang

et al. 2011

Pharmaceutical Biology

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“…As for Alzheimer's disease, polyphenols extracted from grape seeds have been found to inhibit amyloid-β aggregation, reduce amyloid-β production and protect against amyloid-β neurotoxicity in vitro (6,7). In addition, cryptotanshinone (CTS), an active component of the medicinal herb Salvia miltiorrhiza, has been shown to improve learning and memory in several pharmacological models of Alzheimer's disease (8). Further research demonstrated that CTS improved the cognitive ability and promoted APP metabolism involving the non-amyloidogenic product pathway in rat cortical neuronal cells.…”

Section: Introductionmentioning

confidence: 99%

Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells

Yoshida¹,

Okumura²,

Nishimura³

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. In the present study, we aimed to determine the effects of herbs or spices on the expression of presenilin 1, a molecule involved in γ-secretase activity and the generation of amyloid-β peptide in Alzheimer's disease. Western blot analysis revealed that presenilin 1 protein expression was down-regulated by stimulation with turmeric or cinnamon extracts in vitro, while the effects on presenilin 1 gene expression examined by reverse transcriptase-polymerase chain reaction were unaltered. Our results showed that curcumin, a component of turmeric, induced the down-regulation of presenilin 1 protein in Jurkat and K562 cell lines. IntroductionAlzheimer's disease is a neurodegenerative disease caused by amyloid-β accumulation in brain cells combined with oxidative stress and inflammation (1,2). Neurotoxic amyloid-β is an approximately 4-kDa peptide generated via cleavage of the amyloid-β precursor protein (APP) by the γ-secretase proteolytic complex (3). Presenilin is the catalytic member of the γ-secretase complex, and mutations in presenilin are the major cause of early-onset familial Alzheimer's disease. Presenilin is involved in several biological functions, but is well known for its role in the generation of the amyloid-β peptide in Alzheimer's disease and is therefore thought to be an important drug target for this disorder. Thus, an increased understanding of Presenilin may help to improve the development of drugs for Alzheimer's disease and for other neurological diseases (4).Certain herbs have been demonstrated to possess a multitude of beneficial activities, and herbal medications are currently being used for widespread clinical use in disease therapy, as herbs exhibit relatively mild bioavailability and low toxicity (5). As for Alzheimer's disease, polyphenols extracted from grape seeds have been found to inhibit amyloid-β aggregation, reduce amyloid-β production and protect against amyloid-β neurotoxicity in vitro (6,7). In addition, cryptotanshinone (CTS), an active component of the medicinal herb Salvia miltiorrhiza, has been shown to improve learning and memory in several pharmacological models of Alzheimer's disease (8). Further research demonstrated that CTS improved the cognitive ability and promoted APP metabolism involving the non-amyloidogenic product pathway in rat cortical neuronal cells. Moreover, as the Indian diet is rich in herbs and spices, the incidence of Alzheimer's disease in India is considerably low (9,10). However, the precise molecular mechanisms of the therapeutic effects of medicinal herbs and spices are largely undefined, and limited data and a small body of convincing evidence exist at the molecular level (11). Therefore, basic research and development aimed at elucidating the mechanism of action underlying herbal effects should have high priority. We hypothesized that various herbs or spices may affect the γ-secretase proteolytic function. Therefore, we investigated the in vitro effect of several herbs on the expression of presenilin 1 in cultured human cells. Material...

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Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro

Cited by 82 publications

References 24 publications

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Salvianic borneol ester reduces β-amyloid oligomers and prevents cytotoxicity

Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells

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