Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Bonaccini, Laura; Karioti, Anastasia; Bergonzi, Maria Camilla; Bilia, Anna Rita

doi:10.1055/s-0035-1546196

Cited by 30 publications

(22 citation statements)

References 84 publications

(210 reference statements)

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“…Based on these results, we anticipated that the treatment of SM might affect the expression of apoptosis‐related proteins including caspase‐3, Bcl‐2 and Bax in MSCs. Previous studies demonstrated that the root of SM contains lipophilic and hydrophilic compounds such as Sal A, Sal B, salvianic borneol ester (SBE), tanshinone IIA (Tan IIA), rosmarinic acid, cryptotanshinone and danshensu, which decrease cell apoptosis and promote neuroprotective effects against oxidative injury through multiple pathways . Using UHPLC‐UV/Q‐TOF‐MS method, we confirmed that the apoptosis‐related components were included in SM extract (Figure and Table ).…”

Section: Discussionsupporting

confidence: 64%

Salvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditions†

Kim

Lee

et al. 2018

Journal of Pharmacy and Pharmacology

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ObjectivesTo validate the enhanced therapeutic effect of Salvia miltiorrhiza Bunge (SM) for brain ischemic stroke through the anti‐apoptotic and survival ability of mesenchymal stem cells (MSCs).MethodsThe viability and the expression level of cell apoptotic and survival‐related proteins in MSCs by treatment of SM were assessed in vitro. In addition, the infarcted brain region and the behavioural changes after treatment of MSCs with SM were confirmed in rat middle cerebral artery occlusion (MCAo) models.Key findingsWe demonstrated that SM attenuates apoptosis and improves the cell viability of MSCs. In the rat MCAo model, the recovery of the infarcted region and positive changes of behaviour are observed after treatment of MSCs with SM.ConclusionsThe therapy using SM enhances the therapeutic effect for brain ischemic stroke by promoting the survival of MSCs. This synergetic effect thereby proposes a new experimental approach of traditional Chinese medicine and stem cell‐based therapies for patients suffering from a variety of diseases.

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Section: Discussionsupporting

confidence: 64%

Salvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditions†

Kim

Lee

et al. 2018

Journal of Pharmacy and Pharmacology

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“…Based on these results further investigations were carried out with the salvianolic acids 43-45 ( Figure 11) isolated from Salvia miltiorrhiza (Lamiaceae) [57,58]. Salvia miltiorrhiza or Danshen is one of the most important herbal medicinal drugs in the Chinese Traditional Medicines (TCM) to treat bleeding disorders (e.g., menstrual bleeding) and blood stasis [59]. Salvianolic acids are together with tanshinones (lipophilic, diterpenic quinones) the main active principles of the herbal drug.…”

Section: Polyphenolsmentioning

confidence: 99%

“…The main mechanism involved in such processes is the decrease of reactive oxygen species (ROS) levels. Furthermore, there is evidence of the protective role of salvianolic acids in several cardiovascular diseases, osteoporosis, liver fibrosis and hepatic failure [59][60][61].…”

Section: Polyphenolsmentioning

confidence: 99%

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

2016

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Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions. In humans they play an important role as microconstituents of the daily diet, their consumption being considered healthy. The physical and chemical properties of phenolic compounds make these molecules versatile ligands, capable of interacting with a wide range of targets, such as the Carbonic Anhydrases (CAs, EC 4.2.1.1). CAs reversibly catalyze the fundamental reaction of CO 2 hydration to bicarbonate and protons in all living organisms, being actively involved in the regulation of a plethora of patho/physiological processes. This review will discuss the most recent advances in the search of naturally occurring phenols and their synthetic derivatives that inhibit the CAs and their mechanisms of action at molecular level. Plant extracts or mixtures are not considered in the present review.

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“…In virtue of the few side effects, extracts and single constituents are successfully used in clinics in China, Korea, Japan, and other Asian countries for the treatment of heart and cerebrovascular disease, hepatitis, hepatocirrhosis, neurasthenic insomnia, cancer, chronic renal failure, and dysmenorrhea. Both extracts and single constituents have positive effects in CNS neuronal injury and degeneration in several animal models [60].…”

Section: Resveratrol-loaded Nanocarriers To Improve Stability and Effmentioning

confidence: 99%

Improving on Nature: The Role of Nanomedicine in the Development of Clinical Natural Drugs

et al. 2017

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Natural products have been used as a major source of drugs for millennia, and about half of the pharmaceuticals in use today are derived from natural products. However, their efficacy can be limited because of their low hydrophilicity and intrinsic dissolution rate(s), or physical/chemical instability. In addition, they can present scarce absorption, poor pharmacokinetics and bioavailability, scarce biodistribution, first-pass metabolism, trivial penetration and accumulation in the organs of the body, or low targeting efficacy. Novel nanoformulations based on drug delivery systems, namely nanoparticles, micelles, and vesicles, offer significant promise in overcoming these limitations. Nowadays, nanomedicine is crucial in developing appropriate therapeutic treatments of essential drugs, specifically antitumor and antiparasistic agents (i.e., Taxol, vincristine, camptothecin, doxorubicin, artemisinin) and other emerging molecules with pleiotropic functions (i.e., resveratrol, curcumin, salvianolic acid B, honokiol). Additionally, the number of nanoformulations developed with flavonoids, in particular rutin, quercetin, silymarin, and green tea catechins, is constantly increasing, and a significant number of publications have appeared in the last decade pertaining to nanoformulations based on extracts and essential oils. Most of these studies report very promising nanoformulations with sustained release and improved bioavailability at much lower doses than conventional preparations, and in many cases, also a better safety profile.

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Effects of Salvia miltiorrhiza on CNS Neuronal Injury and Degeneration: A Plausible Complementary Role of Tanshinones and Depsides

Abstract: Salvia miltiorrhiza l " Lamiaceae l " tanshinones and depsides l " CNS neuronal injury and degeneration l " in vivo studies l " biochemical mechanisms l " pharmacokinetics

Cited by 30 publications

References 84 publications

Salvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditions†

Salvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditions†

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

Improving on Nature: The Role of Nanomedicine in the Development of Clinical Natural Drugs

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