Cryptosporidiosis and Sinusitis in an Immunodeficient Adolescent

Davis, J.; Heyman, Melvin B.

doi:10.1093/infdis/158.3.649

Cited by 18 publications

(8 citation statements)

References 5 publications

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“…Upper respiratory cryptosporidiosis may cause inflammation of the nasal mucosa, sinuses, larynx, and trachea, accompanied by nasal discharge and voice change (54,61,62). Cryptosporidiosis of the lower respiratory tract typically results in productive cough, dyspnea, fever, and hypoxemia (63)(64)(65)(66).…”

Section: Clinical Illnessmentioning

confidence: 99%

“…Numerous oocysts were found in both endotracheal and fecal samples obtained from a newborn diagnosed with an immunoglobulin deficiency (90). Oocysts were found in sputum and maxillary sinus aspirates from an adolescent with congenital hypogammaglobulinemia and chronic intestinal cryptosporidiosis (54). More recently, a Turkish child with combined immunodeficiency harbored cryptosporidial oocysts in both tracheal and stool specimens (53).…”

Section: Respiratory Cryptosporidiosis In Humans Initial Descriptionsmentioning

confidence: 99%

“…Each of these patients with congenital immune dysfunction manifested cryptosporidiosis in more than one organ system. In addition to intestinal and respiratory infections, two patients had evidence of hepatobiliary invasion (53,54), and one had confirmed cryptosporidia in the pancreatic duct (59).…”

Section: Respiratory Cryptosporidiosis In Humans Initial Descriptionsmentioning

confidence: 99%

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The Evolution of Respiratory Cryptosporidiosis: Evidence for Transmission by Inhalation

2014

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SUMMARY The protozoan parasite Cryptosporidium infects all major vertebrate groups and causes significant diarrhea in humans, with a spectrum of diseases ranging from asymptomatic to life-threatening. Children and immunodeficient individuals are disproportionately affected, especially in developing countries, where cryptosporidiosis contributes substantially to morbidity and mortality in preschool-age children. Despite the enormous disease burden from cryptosporidiosis, no antiprotozoal agent or vaccine exists for effective treatment or prevention. Cryptosporidiosis involving the respiratory tract has been described for avian species and mammals, including immunocompromised humans. Recent evidence indicates that respiratory cryptosporidiosis may occur commonly in immunocompetent children with cryptosporidial diarrhea and unexplained cough. Findings from animal models, human case reports, and a few epidemiological studies suggest that Cryptosporidium may be transmitted via respiratory secretions, in addition to the more recognized fecal-oral route. It is postulated that transmission of Cryptosporidium oocysts may occur by inhalation of aerosolized droplets or by contact with fomites contaminated by coughing. Delineating the role of the respiratory tract in disease transmission may provide necessary evidence to establish further guidelines for prevention of cryptosporidiosis.

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Section: Clinical Illnessmentioning

confidence: 99%

Section: Respiratory Cryptosporidiosis In Humans Initial Descriptionsmentioning

confidence: 99%

Section: Respiratory Cryptosporidiosis In Humans Initial Descriptionsmentioning

confidence: 99%

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The Evolution of Respiratory Cryptosporidiosis: Evidence for Transmission by Inhalation

2014

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“…Many times, especially when CD4 + cells counts are below 180 per mm 3 , cryptosporidiosis had been found to impair the clinical outlook of patients presenting congenital hypogammaglobulinemia, neoplasms, and mainly AIDS, or submitted to bone-marrow and solid organ transplantations 3 6 7 10 16 19 22 26 .…”

Section: Each Patient Was Submitted To Different Numbers Of Faecal Exmentioning

confidence: 99%

Infection by Cryptosporidium parvum in renal patients submitted to renal transplant or hemodialysis

Chieffi

Sens²,

Paschoalotti³

et al. 1998

Rev. Soc. Bras. Med. Trop.

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“…Cryptosporidiurn parvurn is the most c o m m o n species considered to be infectious for humans, and during the last decade cryptosporidiosis has emerged as a cause of diarrhea in humans, particularly in patients with A I D S [1]. In humans, the disease appears to be confined almost exclusively to the gastrointestinal tract, although there have been reports of p u l m o n a r y cryptosporidiosis in immunoc o m p r o m i s e d patients [2,3].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary cryptosporidiosis in the acquired immunodeficiency syndrome

et al. 1996

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Since the beginning of the AIDS epidemic, Cryptosporidium has emerged as a pathogen responsible for diarrhea in humans. Cryptosporidiosis confined to the respiratory tract has been documented only rarely in humans. An HIV-infected patient is described here, who developed pulmonary and intestinal cryptosporidiosis. Lung involvement was proven by biopsy, which also revealed bronchiolitis but no other pathogens. The patient died of respiratory failure 2 months after the onset of respiratory symptoms.

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Cryptosporidiosis and Sinusitis in an Immunodeficient Adolescent

Cited by 18 publications

References 5 publications

The Evolution of Respiratory Cryptosporidiosis: Evidence for Transmission by Inhalation

The Evolution of Respiratory Cryptosporidiosis: Evidence for Transmission by Inhalation

Infection by Cryptosporidium parvum in renal patients submitted to renal transplant or hemodialysis

Pulmonary cryptosporidiosis in the acquired immunodeficiency syndrome

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