Crotofolane Diterpenoids from <i>Croton caracasanus</i>

Chávez, Katiuska; Compagnoneb, Reinaldo S; Riina, Ricarda; Briceño, Alexander; González, Teresa; Squitieri, Emilio; Landaetab, Carlos; Soscrún, Humberto; Suáreza, Alírica I

doi:10.1177/1934578x1300801205

Cited by 9 publications

(15 citation statements)

References 16 publications

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“…Investigations on C. argyrophyllus gave four new crotofolanes ( 199 – 202 ) [ 72 ]. Crotocarasin A–D ( 203 – 206 ) were isolated from the stems of C. caracasanus [ 73 ]. Five new 1, 14- seco -crotofolanes from C. insularis were obtained [ 74 ], while C. dichogamus yielded crotodichogamoin A–B ( 223 – 224 ) [ 75 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents from Croton Species and Their Biological Activities

Liu

Liang

2018

Molecules

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The genus Croton belongs to the Euphorbiaceae family, which comprises approximately 1300 species. Many Croton species have been used as folk medicines. This review focuses on the chemical constituents from Croton species and their relevant biological activities, covering the period from 2006 to 2018. A total of 399 new compounds, including 339 diterpenoids, were reported. Diterpenoids are characteristic components of the Croton species. These isolated compounds exhibited a broad spectrum of bioactivities, including cytotoxic, anti-inflammatory, antifungal, acetylcholinesterase inhibitory, and neurite outgrowth-promoting properties. The present review provides a significant clue for further research of the chemical constituents from the Croton species as potential medicines.

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Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents from Croton Species and Their Biological Activities

Liu

Liang

2018

Molecules

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“…The chemistry of Croton genus shows a high diversity of structures: diterpenes of different skeletons including crotofolanes (Chávez et al, 2013;Kawakami et al, 2015), clerodanes (Pizzolatti et al, 2013;Aldhaher et al, 2017;Qiu et al, 2018), kaurenes (Mora et al, 2011;Mateu et al, 2012;Pereira et al, 2012), labdanes (Bernardino et al, 2017), the more important structures in many species (Xu et al, 2018;Shi et al, 2018). Terpenes (Palmeira Júnior et al, 2006); alkaloids and flavonoids are also common in the genus (de Araújo- Júnior et al, 2004;Suárez et al, 2004;Cerqueira-Coelho et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Suárez

Morocho

Luna

et al. 2021

Revista De La Facultad De Farmacia

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Phytochemical study of two medicinal plants from Ecuador, Tagetes terniflora Kunth, and Croton rivinifolius Kunth, led to the isolation and characterization of the major constituents present in the organic extracts obtained from these plants: 5-(4-acetoxy-1-butynil)-2,2’-bi-thiophene (1), 5-methyl-2,2’:5’,2”- terthiophene (2), patuletin (3) from Tagetes terniflora, and isocorydine (4), sweroside (5), tiliroside (6) from Croton rivinifolius. The structures of these compounds were established by spectroscopic analysis including two-dimensional NMR methods, MS, and comparison with published spectral data. They are recognized as secondary metabolites that represent the chemotaxonomy of Tagetes and Croton genera and could be responsible for the recognized medicinal properties attributed to these species. This paper deals with the first report that shows the presence of these compounds in these plants.

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“…Os estudos realizados com espécies de Croton têm mostrado uma alta diversidade de estruturas químicas: terpenos (KAWAKAMI et al, 2015;CHAVEZ et al, 2013;PIZZOLATTI et al, 2013;ALDAHAER et al, 2017;QIU et al, 2018;MORA et al,2011;MATEU et al, 2012;PEREIRA et al, 2012;BERNARDINO et al, 2017;PALMEIRA et al, 2006;TENE et al, 2009), alcalóides e flavonóides também são comuns no gênero (ARAUJO-JUNIOR et al, 2004;SUÁREZ et al, 2004).…”

Section: Introductionunclassified

Avaliação Da Segurança Não Clínica Do Triterpeno Ácido Acetil Aleuritólico (Aaa) Isolado De Croton Zehntneri Em Zebrafish (Danio Rerio) Adulto

Bezerra

Ferreira

Silva

et al. 2020

BJD

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Este trabalho busca a avaliação da segurança não clínica do triterpeno AAA frente aos ensaios com zebrafish (Danio rerio) adulto. O triterpeno AAA foi isolado da raiz de Croton zehntneri. Soluções desta substância foram preparadas com salina 0,9 %, nas concentrações de (4,0 mg/kg ou 12 mg/kg ou 40 mg/kg; 20 μL i.p) e submetidas ao teste de toxicidade aguda frente ao modelo zebrafish. As mesmas doses foram investigadas quanto ao possível efeito ansiolítico, através do teste de campo aberto. As três dosagens de AAA testadas não foram tóxicas nos zebrafish e não reduziram a atividade locomotora do animal, tendo assim uma possível ação nociceptiva pois a amostra não alterou a atividade locomotora dos animais.

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Crotofolane Diterpenoids from Croton caracasanus

Cited by 9 publications

References 16 publications

Chemical Constituents from Croton Species and Their Biological Activities

Chemical Constituents from Croton Species and Their Biological Activities

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Avaliação Da Segurança Não Clínica Do Triterpeno Ácido Acetil Aleuritólico (Aaa) Isolado De Croton Zehntneri Em Zebrafish (Danio Rerio) Adulto

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