Crosslinked blends of poly(lactic acid) and polyacrylates: AFM, DSC and XRD studies

Kaczmarek, Halina; Nowicki, Marek; Vuković-Kwiatkowska, Irena; Nowakowska, Sylwia

doi:10.1007/s10965-013-0091-y

Cited by 66 publications

(32 citation statements)

References 28 publications

(33 reference statements)

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“…The diffractograms showed that both 3D tubular scaffolds have a signal with the same value as a broadband characteristic of an amorphous peak that increased significantly in comparison with the PLA filament with a lower intensity. These results are in concordance with different studies that reported that PLA is amorphous and depends on the crosslinking of dopants or printed parameters [26][27][28][29].…”

Section: Structural Characterizationsupporting

confidence: 93%

Biocompatibility of Developing 3D-Printed Tubular Scaffold Coated with Nanofibers for Bone Applications

Vázquez-Vázquez

Chanes-Cuevas

Masuoka

et al. 2019

Journal of Nanomaterials

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3D printing with controlled microarchitectures has gained traction in a wide variety of fields, including bone tissue engineering, because it represents an exciting alternative for the synthesis of new scaffolds due to its rapid manufacturing process, high precision, cost-effectiveness, and ease of use. Thus, this study is aimed at evaluating the biocompatibility response of a 3D-printed tubular scaffold coated by a layer of 7% PLA nanofibers. The morphology, structure, and chemical composition of the 3D-printed tubular scaffold were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and surface property analysis by profilometry. The biocompatibility response of the scaffold was assessed by cell adhesion, proliferation, and cell-material interactions of human fetal osteoblasts. Our results showed that 3D printing allowed obtaining similar and reproducible structures and the biocompatibility assays showed that nanofiber coating of the surface of the 3D tubular scaffold promoted an improvement on cell attachment, proliferation, and the morphology of osteoblast cells when compared with a noncoated scaffold. In conclusion, the surface of the 3D-printed tubular scaffold could be improved by the deposition of a nanofiber layer to render a more mimetic and active topography with excellent cellular biocompatibility for bone tissue applications.

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Section: Structural Characterizationsupporting

confidence: 93%

Biocompatibility of Developing 3D-Printed Tubular Scaffold Coated with Nanofibers for Bone Applications

Vázquez-Vázquez

Chanes-Cuevas

Masuoka

et al. 2019

Journal of Nanomaterials

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“…Scaffold specimens were prepared as 6 mm diameter discs (using a puncture), sterilised (88% CO 2 and 12% ethylene oxide at 45 °C with 180 kPa and 55% of humidity for 10 h) and preserved in a desiccator. to their amorphous state and low concentration at the scaffold surface [36].…”

Section: Characterisation Of Wet-spun Fibre Mesh Scaffoldsmentioning

confidence: 99%

Wetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration

Fernandes

Reis

2017

Materials Science and Engineering: C

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We developed a porous poly-L-lactic acid (PLLA) scaffold compounded with borosilicate bioactive glasses (BBGs) endowing it with bioactive properties. Porous PLLA-BBG fibre mesh scaffolds were successfully prepared by the combination of wet spinning and fibre bonding techniques. Micro-computed tomography (μCT) confirmed that the PLLA-BBG scaffolds containing ≈25% of BBGs (w/w) exhibited randomly interconnected porous (58 to 62% of interconnectivity and 53 to 67% of porosity) with mean pore diameters higher that 100μm. Bioactivity and degradation studies were performed by immersing the scaffolds in simulated body fluid (SBF) and ultrapure water, respectively. The PLLA-BBG scaffolds presented a faster degradation rate with a constant release of inorganic species, which are capable to produce calcium phosphate structures at the surface of the material after 7days of immersion in SBF (Ca/P ratio of ~1.7). Cellular in vitro studies with human osteosarcoma cell line (Saos-2) and human adipose-derived stem cells (hASCs) showed that PLLA-BBGs are not cytotoxic to cells, while demonstrating their capacity to promote cell adhesion and proliferation. Overall, we showed that the proposed scaffolds present a tailored kinetics on the release of inorganic species and controlled biological response under conditions that mimic the bone physiological environment.

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“…specified two PLA diffraction peaks at 2θ = 16.4 and 22.6°, respectively. High temperature processing that led to molecule deformation could be the reason for the low crystallinity apart from the rapid cooling that prevent the PLA chains to organize into crystalline lamella with shortened duration …”

Section: Resultsmentioning

confidence: 99%

Poly(lactic acid) composite films reinforced with microcrystalline cellulose and keratin from chicken feather fiber in 1‐butyl‐3‐methylimidazolium chloride

Khaw

Chee

Gan

et al. 2019

J of Applied Polymer Sci

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Amphiphilic keratin from chicken feather fiber (CFF) and hydrophilic cellulose were incorporated as fillers into hydrophobic poly(lactic acid) (PLA) polymer blend. This study implemented ionic liquid (IL) of 1-butyl-3-methylimidazolium chloride (BMIMCl) to dissolve the 1 wt % fillers. The composite films were compared with and without the addition of IL prepared from five sets of ratios of CFF to MCC using measuring mixers and compression molding. Thermal analysis showed that increase in CFF composition decreases the glass-transition temperature (T g ), and crystallization temperature (T c ) as well as increases the degree of crystallinity. PLA composite with the 70/30 ratio of CFF to MCC was found to be the optimum composition in obtaining considerably low T g and high crystallinity. BMIMCl enhanced the miscibility of the composites as observed in scanning electron microscope images and single T g . Apart from creating porous structure and lowering mechanical hardness, BMIMCl also decreased the thermal stability of the PLA composites.

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Crosslinked blends of poly(lactic acid) and polyacrylates: AFM, DSC and XRD studies

Cited by 66 publications

References 28 publications

Biocompatibility of Developing 3D-Printed Tubular Scaffold Coated with Nanofibers for Bone Applications

Biocompatibility of Developing 3D-Printed Tubular Scaffold Coated with Nanofibers for Bone Applications

Wetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration

Poly(lactic acid) composite films reinforced with microcrystalline cellulose and keratin from chicken feather fiber in 1‐butyl‐3‐methylimidazolium chloride

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