Crosslinked alginate/silica/zinc oxide nanocomposite: A sustainable material with antibacterial properties

Salama, Ahmed; Diab, Mohamed A.; Abou-Zeid, Ragab E.; Aljohani, Hind Abdullah; Shoueir, Kamel R.

doi:10.1016/j.coco.2017.11.006

Cited by 58 publications

(21 citation statements)

References 10 publications

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“…The size range of the ZnO NPs in this study was significantly smaller compared to other published reports, thereby implying that this nanocomposite gel would be effective compared to other's works involving ZnO NPs. 46 Rheology and SEM demonstrated the enhanced mechanical and structural properties of 3D printed, ZnO NP enriched, alginate gel scaffolds. Swelling and degradation assays and the moisture retention study on the scaffolds further verified these properties of integrity.…”

Section: Retention Of Humiditymentioning

confidence: 94%

<p>Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy</p>

Cleetus¹,

Alvarez-Primo²,

Fregoso³

et al. 2020

IJN

103

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Introduction: In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing. We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds. Methods: The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis. Titanium dioxide (TiO 2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared. Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis. Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor. Results: 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples. For all samples, the addition of ZnO or TiO 2 resulted in significantly stiffer gels in comparison with the alginate control. Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels. Cell viability of STO-fibroblasts was not adversely affected by the addition of ZnO NPs to the alginate gels. Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels. Discussion: The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing. This scaffold can provide a cost-effective and durable antibacterial treatment option.

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Section: Retention Of Humiditymentioning

confidence: 94%

<p>Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy</p>

Cleetus¹,

Alvarez-Primo²,

Fregoso³

et al. 2020

IJN

103

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“…Considering the literature, some authors replaced OPC with 10% and 15% bagasse ash to optimize the replacement level of OPC, but these papers did not focus on the particle size when the waste was calcined to produce ultrafine nanopowder. Nanotechnology is a trend in many applications [28][29][30][31]. Pure CaO is used in many applications, such as the cement industry, biodiesel production, the petroleum industry, electric lighting, paper industry, and power production [32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Calcium Oxide Nanoparticles from Industrial Waste on the Performance of Hardened Cement Pastes: Physicochemical Study

et al. 2020

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Large amounts of carbonated mud waste (CMW) require disposal during sugar manufacturing after the carbonation process. The lightweight of CMW enables its utilization as a partial replacement for the cement to reduce costs and CO2 emissions. Here, various levels of CMW, namely, 0, 5, 10, 15, 20, and 25 wt.% were applied to produce composite cement samples with ordinary Portland cement (OPC) as a regular mix design series. Pure calcium oxide (CaO) nanoparticles were obtained after the calcination of CMW. The techniques of X-ray fluorescence spectrometers (XRF), Transmission electron microscope (TEM), Selected area diffraction (SAED), Scanning electron microscope (SEM), energy dixpersive X-ray (EDX), and dynamic light scattering (DLS) were used to characterize the obtained CaO nanoparticles. According to the compressive strength and bulk density results, 15 wt.% CMW was optimal for the mix design. The specific surface area increased from 27.8 to 134.8 m2/g when the CMW was calcined to 600 °C. The compressive strength of the sample containing 15% CMW was lower than the values of the other pastes containing 5% and 10% CMW at all of the curing times. The porosity factor of the hardened cement pastes released with a curing time of up to 28 days. Excessive CMW of up to 25 wt.% reduced the properties of OPC.

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“…As shown in Table III, when Cu 2 O was added to the modified PES membranes with SF or SZ in the ratio of 3-4 wt %, antibacterial activity was detected against P. aeruginosa ( Figure S5). Both PES-SF 3…”

Section: Antimicrobial Evaluationmentioning

confidence: 99%

“…Natural polymers such as chitosan, cellulose, and alginate, have attracted researchers in many medial and environmental applications . Although natural polymers have excellent properties including nontoxic, biodegradable, and abundant materials, they have been also known to exhibit less thermal and mechanical stabilities in comparison to synthetic polymers such as poly(vinyl alcohol) or thermoplastic polymers such as polyethersulfone (PES).…”

Section: Introductionmentioning

confidence: 99%

Exploring the effect of organic–inorganic additives loaded on modified polyethersulfone membranes

Alenazi

Alamry

Hussein

et al. 2019

J of Applied Polymer Sci

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In this work, a novel modified polyethersulfone (PES) membrane was made by blending PES with organic biomolecules which were N1,N4‐bis(4‐sulfamoylphenyl)terephthalamide (SF), and N1, N4‐bis[4‐(N‐(5‐methylisoxazol‐3‐yl)sulfamoyl)phenyl]terephthalamide (SZ) to afford PES‐SF and PES‐SZ membranes. Antifouling properties of these modified membranes were examined against different types of bacteria and a fungus as well as by measuring the contact angle. The results showed the addition of these organic additives to PES membranes did not improve the hydrophilicity and exhibit any microbial activity. Thus, Cu2O nanoparticles were used with different concentrations to afford PES‐SF‐Cu2O and PES‐SZ‐Cu2O nanocomposites membranes. The results showed when Cu2O nanoparticles (3 wt %) was added to PES‐SF3 and PES‐SZ3 membranes, both membranes showed the best hydrophilicity with 67° for PES‐SF3‐Cu2O membrane and 77° for PES‐SZ3‐Cu2O membranes. PES‐SF3‐Cu2O and PES‐SZ3‐Cu2O membranes showed antibacterial against Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. To evaluate the anticoagulant activity of the PES‐SF and PES‐SZ membranes, the clotting times using the activated partial thromboplastin time (APTT) and prothrombin time (PT) were measured. The results showed PT level was prolonged for the pure PES membrane with 13 s and for PES‐SF1 membrane with 12.4 s while the PES‐SZ1 membrane showed no difference from the control (pure plasma). Contrary to the PT factor, APTT level of the PES‐SF membrane showed the longest time with 43 s. The results of APPT and PT seemed somewhat satisfactory for the PES‐SF while the PES‐SZ membrane did not show any difference from the control sample. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47686.

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Crosslinked alginate/silica/zinc oxide nanocomposite: A sustainable material with antibacterial properties

Cited by 58 publications

References 10 publications

<p>Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy</p>

<p>Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy</p>

Evaluation of Calcium Oxide Nanoparticles from Industrial Waste on the Performance of Hardened Cement Pastes: Physicochemical Study

Exploring the effect of organic–inorganic additives loaded on modified polyethersulfone membranes

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