Cross-sectional study on the correlation of serum uric acid with disease severity in Korean patients with psoriasis

Kwon, Hyuck Hoon; Kwon, In Ho; Choi, Ji Woong; Youn, Jai-Il

doi:10.1111/j.1365-2230.2010.03988.x

Cited by 51 publications

(68 citation statements)

References 21 publications

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“…It is thought that hyperuricemia may result from accelerated epidermal turn-over [201]. Studies conducted in the second half of the 20 th century which aimed to determine the relationship between hyperuricemia and psoriasis, produced conflicting results [201].…”

Section: Uric Acidmentioning

confidence: 99%

Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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Section: Uric Acidmentioning

confidence: 99%

Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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“…Ayrıca, kadın hastalarda yüksek ürik asit düzeyleri olan hastalarda metabolik sendrom riskinin daha yüksek, erkek hastalarda normal serum ürik asit düzeyleri olanlarda bile düşük düzeyde olanlara göre metabolik sendrom riskinin daha yüksek olduğu gösterilmiştir 22 . Kore'den yapılan başka bir çalışmada psoriazis hastalarında serum ürik asit düzeylerinin VKİ ile korelasyon gösterdiği bildirilmiştir 11 . Biz çalışmamızda psoriazis hastalarında metabolik sendrom sıklığının kontrol grubuna göre daha fazla ve ürik asit düzeyinin daha yüksek olduğunu saptadık.…”

Section: Abstract: Metabolic Syndrome Uric Acid Psoriasisunclassified

“…Önemi son yıllarda daha iyi anlaşılmış metabolik bir marker olan ürik asitin metabolik sendrom, hipertansiyon ve kardiyovasküler hastalıklarla ilişkili olduğu düşünülmektedir [6][7][8][9] . Psoriazis hastalarında ürik asit yüksekliği eskiden beri üzerinde çalışılan ve iyi bilinen bir durumdur 10,11 . Ayrıca, serum ürik asit düzeylerinin psoriazisin şiddet ve yaygınlığı ile korele olduğu gösterilmiştir 11 .…”

Section: Introductionunclassified

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The role of uric acid in metabolic syndrome in patients with psoriasis

Solak¹,

Dikicier²,

Erdem³

2017

TURKDERM

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Background and Design:Psoriasis patients have increased risk of obesity, metabolic syndrome and cardiovascular disease. Uric acid is a metabolic marker associated with metabolic syndrome and cardiovascular diseases. Uric acid levels increase in psoriasis as well. The aim of this study was to investigate the role of uric acid in metabolic syndrome in patients with psoriasis. Materials and Methods: Chronic plaque psoriasis patients who presented to the dermatology outpatient clinics in a university-affiliated training and research hospital and age-and gender-matched healthy individuals were included in the study. Waist circumference, height and weight measurements in both groups were recorded, and body mass index was calculated. Serum uric acid, urea, creatinine, C-reactive protein, fasting blood glucose, high-density lipoprotein cholesterol, total cholesterol, triglyceride and insulin levels were determined. Metabolic syndrome and insulin resistance status were evaluated. The findings were compared statistically. Results: Seventy patients with chronic plaque psoriasis (37 females, 33 males) and 60 healthy individuals (31 females, 29 males) were included in the study. The prevalence of metabolic syndrome and uric acid levels were found to be higher in the psoriasis group than in control group (p=0.003 and p=0.008, respectively). Serum uric acid levels and Psoriasis Area and Severity Index scores were higher in psoriasis patients with metabolic syndrome than in those without metabolic syndrome when psoriasis patients were evaluated separately (p=0.041, p=0.024, respectively). A positive correlation was observed between abdominal circumference and serum uric acid levels in psoriasis patients (p=0.003, r=0.350). AbstractAmaç: Enflamatuvar bir hastalık olan psoriaziste son yıllarda obezite, metabolik sendrom ve kardiyovasküler hastalık riskinin arttığı gösterilmiştir. Ürik asit metabolik sendrom ve kardiyovasküler hastalıklarla ilişkili ve aynı zamanda psoriaziste arttığı bilinen metabolik bir belirteçtir. Psoriazis hastalarındaki artmış metabolik sendrom riskinde ürik asitin rol oynayıp oynamadığını araştırmayı amaçladık. Gereç ve Yöntem: Üniversite afiliye eğitim ve araştırma hastanesi dermatoloji polikliniğinde görülmüş olan kronik plak psoriazisli hastalar ile yaş ve cinsiyet uyumlu sağlıklı kontrol grubu çalışmaya alındı. Hasta ve kontrol grubunun bel çevresi, boy ve kilo ölçümü kaydedildi. Vücut kitle indeksleri hesaplandı. Serum ürik asit, üre, kreatinin, C-reaktif protein açlık glukoz, yüksek yoğunluklu lipoprotein kolesterol, total kolesterol, trigliserid ve insülin değerleri ölçümleri kaydedildi. Hasta ve kontrol grubunda metabolik sendrom varlığı ve insülin direnci değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırıldı. Bulgular: Kronik plak psoriazisli 70 hasta (37 kadın, 33 erkek) ile 60 sağlıklı kontrol (31 kadın, 29 erkek) çalışmaya alındı. Psoriazis hastalarında metabolik sendrom sıklığının kontrol grubuna göre daha sık ve ürik asit düzeyinin daha yüksek olduğunu saptadık (p=0,003, p=0,008, sır...

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“…Powyższe obserwacje dały podstawy do sformułowania teorii, że łuszczyca, która jest chorobą związaną ze zwiększeniem szybkości proliferacji komórek naskórka (ang. turn-over) i syntezy kwasów nukleinowych, w tym mechanizmie może prowadzić do hiperurykemii [46]. Podobne zjawisko jest obserwowane w zespołach mieloproliferacyjnych [49].…”

Section: Kwas Moczowy a łUszczycaunclassified

Effects of hyperuricemia on the skin

Owczarczyk‐Saczonek¹,

Krajewska–Włodarczyk²,

Placek³

2017

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StrESzczEniEKwas moczowy jest końcowym produktem metabolizmu puryn, a jego stężenie w surowicy u osób zdrowych wynosi 3-7 mg/dl. Hiperurykemia wiąże się z wyższym ryzykiem wystąpienia incydentów sercowo-naczyniowych, a wzrost stężenia kwasu moczowego, zależny od nieprawidłowych nawyków żywieniowych, jest charakterystyczny dla populacji krajów wysoko rozwiniętych. Hiperurykemia może prowadzić do pojawiania się na skórze różnych zmian chorobowych. Jednocześnie kwas moczowy jest ważnym przeciwutleniaczem, odpowiedzialnym za 2/3 pojemności antyoksydacyjnej organizmu. W pracy przedstawiono zmiany skórne towarzyszące dnie moczanowej (guzki dnawe, "dna prosówkowa", dnawe zapalenie tkanki podskórnej). Dokonano także przeglądu piśmiennictwa i omówiono znaczenie hiperurykemii w łuszczycy. Świadomość i wiedza dermatologów na temat hiperurykemii może wpłynąć na szybsze rozpoznawanie zaburzeń metabolicznych u pacjentów na podstawie oceny skóry. AbStrActUric acid is a final product of purine metabolism, and its concentration in the blood serum of healthy individuals is 3-7 mg/dl. Hyperuricemia is associated with higher cardiovascular risk, and its prevalence related to nutrition profile is characteristic for highly developed societies. It can lead to the appearance of certain skin lesions. On the other hand, uric acid is an important antioxidant, which is responsible for 2/3 of the antioxidant capacity of the body. In this article, the authors present skin lesions associated with gout (tophi, "miliarial gout", gouty panniculitis) and review the data of the literature and discuss the importance of hyperuricemia in psoriasis. Dermatologists' awareness and knowledge about hyperuricemia may favor a faster diagnosis of this metabolic disorder based on skin lesions. WPrOWAdzEniEKwas moczowy (ang. uric acid -UA) jest końco-wym produktem metabolizmu puryn pochodzących z diety, syntezy de novo oraz rozpadu komórek. Puryny są rozkładane przez szereg enzymów, tworzą ksantynę i hipoksantynę, które następnie są utleniane przez oksydazę ksantynową do kwasu moczowego. Stężenie kwasu moczowego w surowicy u osób zdrowych wynosi 3-7 mg/dl (180-420 µmol/l) i jest

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Cross-sectional study on the correlation of serum uric acid with disease severity in Korean patients with psoriasis

Abstract: SUAC in patients with psoriasis is positively associated with PASI, extent of skin involvement and BMI for both genders independently.

Cited by 51 publications

References 21 publications

Biochemical markers of psoriasis as a metabolic disease

Biochemical markers of psoriasis as a metabolic disease

The role of uric acid in metabolic syndrome in patients with psoriasis

Effects of hyperuricemia on the skin

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