The role of uric acid in metabolic syndrome in patients with psoriasis

Abstract

Background and Design:Psoriasis patients have increased risk of obesity, metabolic syndrome and cardiovascular disease. Uric acid is a metabolic marker associated with metabolic syndrome and cardiovascular diseases. Uric acid levels increase in psoriasis as well. The aim of this study was to investigate the role of uric acid in metabolic syndrome in patients with psoriasis. Materials and Methods: Chronic plaque psoriasis patients who presented to the dermatology outpatient clinics in a university-affiliated training and research hospital and age-and gender-matched healthy individuals were included in the study. Waist circumference, height and weight measurements in both groups were recorded, and body mass index was calculated. Serum uric acid, urea, creatinine, C-reactive protein, fasting blood glucose, high-density lipoprotein cholesterol, total cholesterol, triglyceride and insulin levels were determined. Metabolic syndrome and insulin resistance status were evaluated. The findings were compared statistically. Results: Seventy patients with chronic plaque psoriasis (37 females, 33 males) and 60 healthy individuals (31 females, 29 males) were included in the study. The prevalence of metabolic syndrome and uric acid levels were found to be higher in the psoriasis group than in control group (p=0.003 and p=0.008, respectively). Serum uric acid levels and Psoriasis Area and Severity Index scores were higher in psoriasis patients with metabolic syndrome than in those without metabolic syndrome when psoriasis patients were evaluated separately (p=0.041, p=0.024, respectively). A positive correlation was observed between abdominal circumference and serum uric acid levels in psoriasis patients (p=0.003, r=0.350). AbstractAmaç: Enflamatuvar bir hastalık olan psoriaziste son yıllarda obezite, metabolik sendrom ve kardiyovasküler hastalık riskinin arttığı gösterilmiştir. Ürik asit metabolik sendrom ve kardiyovasküler hastalıklarla ilişkili ve aynı zamanda psoriaziste arttığı bilinen metabolik bir belirteçtir. Psoriazis hastalarındaki artmış metabolik sendrom riskinde ürik asitin rol oynayıp oynamadığını araştırmayı amaçladık. Gereç ve Yöntem: Üniversite afiliye eğitim ve araştırma hastanesi dermatoloji polikliniğinde görülmüş olan kronik plak psoriazisli hastalar ile yaş ve cinsiyet uyumlu sağlıklı kontrol grubu çalışmaya alındı. Hasta ve kontrol grubunun bel çevresi, boy ve kilo ölçümü kaydedildi. Vücut kitle indeksleri hesaplandı. Serum ürik asit, üre, kreatinin, C-reaktif protein açlık glukoz, yüksek yoğunluklu lipoprotein kolesterol, total kolesterol, trigliserid ve insülin değerleri ölçümleri kaydedildi. Hasta ve kontrol grubunda metabolik sendrom varlığı ve insülin direnci değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırıldı. Bulgular: Kronik plak psoriazisli 70 hasta (37 kadın, 33 erkek) ile 60 sağlıklı kontrol (31 kadın, 29 erkek) çalışmaya alındı. Psoriazis hastalarında metabolik sendrom sıklığının kontrol grubuna göre daha sık ve ürik asit düzeyinin daha yüksek olduğunu saptadık (p=0,003, p=0,008, sır...

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies

“…The mean age of patients was 40.89 years (range: 26.03-49.70 years) and that of healthy controls 39.64 years (range: 23.40-49.48 years). Thirteen studies were reported from Turkey [16][17][18][19][20][21][22][23][24][25][26][27][28], eight from Iran [11,[29][30][31][32][33][34][35], seven from India [36][37][38][39][40][41][42], five from Poland [5,[43][44][45][46], three from the USA [47][48][49], two from Spain [2,10], Japan [50,51], Egypt [52,53], and Italy [54,55], one from Austria [56], Romania [1], Portugal [57], Iraq [58], and China [59]. Th...…”