Cross‐Linked Sodium Alginate‐g‐poly(Acrylic Acid) Structure: A Potential Hydrogel Network for Controlled Delivery of Loxoprofen Sodium

Abstract

A series of sodium alginate-graft-poly(acrylic acid) hydrogels (SA-g-pAA hydrogels) were synthesized with sodium alginate (SA) and acrylic acid (AA) in aqueous solution, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and ammonium peroxodisulfate (APS) as an initiator. Hydrogels were evaluated for thermal stability (TGA & DSC), revealing their higher strength toward thermal variation as compared to individual components. SEM micrographs show smooth and solid outer surface with a lack of porosity on it. FTIR results revealed the grafting reaction of AA on SA. Hydrogels were then evaluated for pH responsive behavior by equilibrium swelling ratio and swelling dynamics at low and high pH. Furthermore, these cross-linked networks were also tested for the release of Loxoprofen sodium hydrate (LSH). Drug was loaded by diffusion method and showed pH-dependent drug release characteristics. Korsmeyer-Peppas model is the best fit model to explain drug release from the cross-linked network. Maximum swelling, drug loading, and release has been observed at pH 7.4. It is concluded that highly stable SA and AA based polymeric matrixes are developed. These polymeric matrixes have potential to be used as a carrier for controlled delivery of LSH.

Preparation and in Vitro Evaluation of Soya Lecithin Based Nano Transfersomal Dispersion for Loxoprofen Sodium

“…Further work was applied, where the DSC spectrum of the drug (figure 2) showed sharp peak at 204°C which corresponding to melting point of the drug. showed to be identical with the reported data of loxoprofen sodium, (as shown in figure 4) and the selected λ max was at 223 nm [22] (A) (B) Absorbance (nm)…”

Synthesis of a Biodegradable Polymer of Poly (Sodium Alginate/Ethyl Acrylate)

“…Hydrogels can be synthesized from sodium alginate with acrylic polymers or copolymers, and with other compounds such as acrylamide to create an interpenetrating network (IPN) between the polymers based on electrostatic phenomena [ 15 ]. In addition, there are investigations in which a polymerization of sodium alginate (SA) and an acrylic monomer is carried out, using in most cases a crosslinker such as N, N-methylene-bis-acrylamide (MBAA) or ethylene glycol dimethacrylate (EGDMA); to obtain hydrogels with different applications [ 16 , 17 , 18 ].…”

Preparation and Characterization of Ionic Conductive Poly(acrylic Acid)-Based Silicone Hydrogels for Smart Drug Delivery System

“…In addition, PAA hydrogels are non-toxic compounds that have the advantage of easy chemical modification. They also have anionic properties (due to having carboxyl groups) that can be used as an electrode pad for smart drug delivery system [ 25 , 26 ]. However, because the hydrogels prepared using only PAA have disadvantages (low durability and weak mechanical properties), these hydrogels are poorly able to endure life activities when a PAA hydrogel patch is attached to the skin of a human body [ 27 , 28 , 29 ].…”