Preparation and Characterization of Ionic Conductive Poly(acrylic Acid)-Based Silicone Hydrogels for Smart Drug Delivery System

Abstract

In this study, we developed a smart drug delivery system that can efficiently deliver the required amounts of drugs using the excellent ion conductivity of poly(acrylic acid) (PAA) and an electrical stimulus. As a result of its having carboxyl groups, PAA hydrogel can be used in drug delivery patches to release drugs by ionic conductivity. However, PAA hydrogel has low durability and poor mechanical properties. The carboxyl group of PAA was combined with a siloxane group of silicone using electron-beam irradiation to easily form a crosslinked structure. The PAA–silicone hydrogel has excellent mechanical properties. Specifically, the tensile strength increased more than 3.5 times. In addition, we observed its cell compatibility using fluorescence staining and CCK-8 assays and found good cell viability. Finally, it was possible to control the drug delivery rate efficiently using the voltage applied to the ion-conductive hydrogel. As the voltage was increased to 3, 5, and 7 V, the amount of drug released was 53, 88, and 96%, respectively. These excellent properties of the PAA–silicone hydrogel can be used not only for whitening or anti-wrinkling cosmetics but also in medical drug-delivery systems.

Effective BMP-2 Release and Mineralization on a Graphene Oxide/Polyvinylpyrrolidone Hydrogel Forming Poly (ε-Caprolactone) Nanofibrous Scaffolds

“…Gamma-ray irradiation can induce various chemical reactions (e.g., polymerization, decomposition, surface modification, and crosslinking) using radical recombination reactions due to their high energy and self-ionization. In addition, it has the advantage of being able to induce reactions in various environments (e.g., oxygen, nitrogen, and vacuum) and states (e.g., solids and liquids) [ 34 , 43 , 44 ]. Various reactions can be induced by controlling the polymer properties and the conditions of the gamma-ray-irradiation dose and dose rate.…”

“…We confirmed the change in drug release according to electrical stimulation using the ionic conductivity characteristics of PAAc. The cumulative release of L-ascorbic acid increased as the electrical stimulation was increased from 0 to 7 V [ 34 ].…”

Guard Cell‐Inspired Ion Channels: Harnessing the Photomechanical Effect via Supramolecular Assembly of Cross‐Linked Azobenzene/Polymers

“…Precise control over ion transport and charge mobility via external stimuli offers considerable opportunities for developing next-generation smart materials, which are crucial in various fields such as drug delivery, [1,2] biomedical engineering, [3,4] and sensors. [5,6] Over the years, various stimuli-responsive materials with adaptive responses triggered by particular stimuli, including heat, [7,8] pH, [9,10] electricity, [11,12] pressure, [13,14] and light [15,16] have been applied to artificial ion channels owing to their remote controllability, high sensitivity, and reversibility.…”

Thermosensitive Scattering Hydrogels Based on Triblock Poly-Ethers: A Novel Approach to Solar Radiation Regulation

“…This transition increases the material’s barrier rate to near-infrared wavelengths, thus reducing solar energy transmittance [ 18 ]. However, the practical application of vanadium dioxide is limited due to its transformation temperature of 68 °C and its brown-yellow color [ 19 ].…”