Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin

Caddeo, Carla; Dı́ez-Sales, Octavio; Pons, Ramón; Carbone, Claudia; Ennas, Guido; Puglisi, Giovanni; Fadda, Anna Maria; Manconi, Maria

doi:10.1016/j.jcis.2015.09.013

Cited by 109 publications

(46 citation statements)

References 25 publications

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“…The formulation was able to modulate the quercetin release profile according to the pH, increasing the bioavailability of the encapsulated drug. Chitosan was able to protect quercetin-loaded liposomes and provide special resistance to acidic environments, such as that found in gastric environment [79].…”

Section: Liposomesmentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: Liposomesmentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…Single crystal data can be found only on di-and monohydrate forms [43,44], however only the powder diffraction pattern generated by the CIF file of dihydrate form (Cambridge Structural Database Fef-bex01) is identical with our parent quercetin sample. Based on their X-ray powder diffraction, 13 C, 1 H NMR, and quantum chemical computations data Filip et al [36] proposed a reliable crystal structure model of anhydrous quercetin with monoclinic system and space group of P21/a. The powder diffraction pattern generated by the CIF file Quer3 presented in their electronic supplementary information gave identical reflections with our samples ( Fig 1).…”

Section: Materials Characterizationmentioning

confidence: 99%

“…The system allows the delivery of bioactive molecules to the intestinal tract, avoiding burst release in the lower pH in the stomach. This way quercetin can be used for the neurological diseases treatment of oxidative stress and inflammation related disorders in the intestinal tract [13]. There is information that delivery systems based on liposomes improve the transdermal diffusion of hydrophobic antioxidants like quercetin [13].…”

Section: Introductionmentioning

confidence: 99%

“…This way quercetin can be used for the neurological diseases treatment of oxidative stress and inflammation related disorders in the intestinal tract [13]. There is information that delivery systems based on liposomes improve the transdermal diffusion of hydrophobic antioxidants like quercetin [13]. Histopathological analysis shows that these systems protect the skin from photo-damage caused by UVB radiation as well [14].…”

Section: Introductionmentioning

confidence: 99%

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Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Popova

Trendafilova

Szegedi

et al. 2016

Microporous and Mesoporous Materials

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SBA-16 and MCM-41 silica materials were synthesized and modified by post-synthesis method with different amounts of Zn (2 and 4 wt.%). Quercetin, a flavonol compound, was loaded by incipient wetness impregnation method on the pure silica and Zn-modified mesoporous MCM-41 and SBA-16 supports. The parent and drug loaded formulations were characterized by powder XRD, N 2 physisorption, thermal analysis, TEM, UV Vis and FT-IR spectroscopies. The formation of Zn:quercetin complex was studied by FT-IR spectroscopy and quantum-chemical calculations. Loading of quercetin on mesoporous carriers made the sustained delivery of the bioactive compound possible in a buffer with pH = 5.5, typical of dermal formulations. The results from the release experiments are in good accordance with the inter-action energy between the bioactive molecule and non-modified and Zn-modified mesoporous materials, predicted by the quantum-chemical calculations. For the first time the formation of the most stable Zn quercetin complexes loaded on the mesoporous silica materials were determined. The obtained mesoporous delivery systems with Zn-quercetin complex are promising as dermal formulations.

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“…Chitosan is a polymer well known for its attractive properties, such as biocompatibility, biodegradability and bioadhesivity (Gulbake and Jain, 2012). Chitosomes maintained the positive properties of liposomes, but showed greater stability and provided longer residence times in the gastrointestinal tract, in virtue of their mucoadhesion properties (Takeuchi et al, 2003(Takeuchi et al, , 2005Werle and Takeuchi, 2009;Manconi et al, 2010Manconi et al, , 2013Shao et al, 2015;Caddeo et al, 2016).…”

Section: Introductionmentioning

confidence: 99%