Crohn's disease and fatigue: Constancy and co-variations of activity of the disease, depression, anxiety and subjective quality of life

Banovic, Ingrid; Gilibert, Daniel; Cosnes, Jacques

doi:10.1080/13548501003759155

Cited by 50 publications

(40 citation statements)

References 41 publications

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“…We chose a one-dimensional BFI questionnaire that offers a quick fatigue assessment, and the MFI – a more in-depth, multifactorial description of fatigue [19, 21]. These tools were chosen due to their frequent use to assess fatigue in IBD disease studies [2, 7, 10, 13, 14, 24-26] and because they represented two different approaches to fatigue measurement. To date, there have been very few studies that focused on fatigue in IBD as the primary outcome measure [2], and explored the symptom in its multi-dimensional nature.…”

Section: Introductionmentioning

confidence: 99%

Detailed Multi-Dimensional Assessment of Fatigue in Inflammatory Bowel Disease

et al. 2018

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Background: Fatigue is a symptom commonly reported by patients with inflammatory bowel disease (IBD). Treating any underlying inflammation in active disease improves the health outcomes and decreases fatigue, but fatigue still persists in remission, negatively affecting patients’ quality of life and posing a challenge for the treating physician. The aim of this study was to describe the prevalence of fatigue in patients with IBD and investigate possible contributing factors. Methods: Recruited IBD patients from the Otago region in southern New Zealand were asked to complete demographic, physical activity (IPAQ) and fatigue questionnaires (Brief Fatigue Inventory, Multidimensional Fatigue Inventory). Disease activity and factors contributing to fatigue were assessed through self-reporting and laboratory biomarkers. Results: One hundred and thirteen of the contacted 469 IBD patients participated in the study. Depending on the questionnaire used, the prevalence of fatigue in IBD was high in remission (39.5–44.2%) but significantly higher (p < 0.001) in active disease (80.0–82.9%). Several factors such as age, disease duration, level of physical activity, gender and diet were found to be associated with increased fatigue and were attributed to either mental or physical fatigue categories. Multifactorial Fatigue Inventory provided insights into different types of fatigue, and revealed a significant mental fatigue component in both active and remission disease patients. Iron deficiency was not associated with fatigue levels. Conclusions: Fatigue in IBD is multi-faceted and highly prevalent in both active and remission IBD. Further investigations, addressing the complexity of the symptom and its reporting are needed.

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Section: Introductionmentioning

confidence: 99%

Detailed Multi-Dimensional Assessment of Fatigue in Inflammatory Bowel Disease

et al. 2018

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“…Anxiety is reported to be present in up to 40% of patients with IBD [11, 14, 31] and is more likely to be present in patients with active disease [13, 14, 16, 17]. There are few reports of how anxiety may change over time or with change in disease activity.…”

Section: Discussionmentioning

confidence: 99%

“…Previous literature suggests that anxiety is present in up to 40% of adults with CD [9, 11-13] and that up to 10% suffer from depression [11, 13-15]. Active CD is associated with greater symptoms of anxiety and depression [13, 14, 16, 17], and the achievement of disease remission mostly results in a reduction in symptoms of anxiety and depression [10]. There is some evidence that the presence of major depression, or high levels of anxiety, is associated with a poorer treatment outcome [18].…”

Section: Introductionmentioning

confidence: 99%

Newly Diagnosed Crohn’s Disease Treated with Standard Care or Enteral Nutrition: Psychological Outcomes over 6 Months

et al. 2019

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Background and Aim: Impaired health-related quality of life and higher rates of anxiety and depression are observed in patients with Crohn’s disease. This single center study aimed to describe and compare longitudinal psychological outcomes of newly diagnosed Crohn’s disease patients treated with standard care or enteral nutrition to induce remission. Methods:Two separate cohorts of patients were recruited from one center and treated with standard care (n = 22) or enteral nutrition (n = 18) to induce disease remission. Disease activity, quality of life, anxiety, and depression were assessed at diagnosis and month 6. Results:At baseline, quality of life (n = 40) was not correlated with disease activity; symptoms of anxiety and depression were present in 15 (38%) and 5 (13%) of the 40 patients, respectively. Significant improvements in quality of life (p <0.0001) and anxiety scores (p = 0.002) were observed after 2 weeks of exclusive enteral nutrition, and at month 6 significant improvements in all psychological outcomes were observed. At month 6, patients who received standard care had a significant improvement in quality of life (p = 0.004), but not in anxiety or depression scores, and there were no differences in psychological outcomes between the treatment groups. Overall, 34/40 (85%) patients were in clinical remission at month 6, and a clinically significant quality of life score was achieved by 31/40 (78%). Conclusions:Patient health-related quality of life and symptoms of anxiety and depression improved as disease activity improved, and 6 months after diagnosis psychological outcomes were similar in patients treated with standard care or enteral nutrition to initially induce remission.

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“…I fire studier (9,10,13,28) hadde man vurdert depresjon i forhold til fatigue, og i alle var det en signifikant positiv assosiasjon. Andre undersøkte faktorer var tett knyttet opp mot depresjon, slik som sykdomsrelaterte bekymringer, angst, stress og psykososiale forhold (13,15,19,21,34).…”

Section: Andre Faktorer Assosiert Med Fatigueunclassified

Utmattelse ved inflammatorisk tarmsykdom

Grimstad

Norheim

2016

Tidsskriftet

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RESULTATER 28 av i alt 156 artikler ble inkludert. 13 ulike instrumenter for å måle fatigue og 11 mål på sykdomsaktivitet ble anvendt i de ulike studiene. Fatigue forekommer hyppigere hos dem som er rammet av inflammatorisk tarmsykdom (22 -77 %) enn i normalbefolkningen (2 -12 %). Aktiv sykdom og depresjon er assosiert med høyere grad av fatigue.FORTOLKNING Fatigue er et betydelig problem ved inflammatorisk tarmsykdom, og forekomsten og mulige risikofaktorer varierer fordi det er benyttet ulike mål for grad av utmattelse/fatigue og sykdomsaktivitet i heterogene studiepopulasjoner.

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Crohn's disease and fatigue: Constancy and co-variations of activity of the disease, depression, anxiety and subjective quality of life

Cited by 50 publications

References 41 publications

Detailed Multi-Dimensional Assessment of Fatigue in Inflammatory Bowel Disease

Detailed Multi-Dimensional Assessment of Fatigue in Inflammatory Bowel Disease

Newly Diagnosed Crohn’s Disease Treated with Standard Care or Enteral Nutrition: Psychological Outcomes over 6 Months

Utmattelse ved inflammatorisk tarmsykdom

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