Crohn's Disease and Discitis

Kavia, Sanjay; Gilbert, Jennifer L.

doi:10.1177/0141076809701008

Cited by 5 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Purulent musculoskeletal complications can occur as a result of abscessing/fistulizing Crohn's disease (CD) 1–5. There have been a few reported cases of gluteal muscle abscess complicating CD.…”

mentioning

confidence: 99%

“…Purulent musculoskeletal complications of CD have been described 1–5. In a study of 552 patients with CD who underwent computed tomography of the abdomen and pelvis at a tertiary referral center, 23 patients (4%) had purulent musculoskeletal complications of CD 1.…”

mentioning

confidence: 99%

“…Other unusual purulent musculoskeletal manifestations of CD include vertebral and sacral osteomyelitis,4 septic discitis,5 septic arthritis,6 and spinal epidural abscess7,8 with or without associated meningitis. Our patient also exhibited sciatic nerve irritation secondary to extension of the abscess into the sacro‐sciatic foramen.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Piriformis Muscle Abscess Complicating Crohnʼs Ileitis

Berkelhammer

Debre

Gutti

2005

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Piriformis Muscle Abscess Complicating Crohnʼs Ileitis

Berkelhammer

Debre

Gutti

2005

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

“…1 Although TNF-␣ antagonists seem to be effective in the treatment of refractory psoriasis, 2 in the last 2 years unexpected onset of psoriasis or psoriasiform skin lesions has been reported in patients receiving treatment with TNF-␣ inhibitors for rheumatological or gastroenterological conditions.…”

Section: To the Editormentioning

confidence: 99%

Spondylodiscitis representing as the very first sign of Crohnʼs disease

Zöld

Barta

Zeher

2007

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

“…Při analýze zkušeností současných autorů je evidentní, že se na vzniku hematogenní i pooperační infekce páteře může podílet celá řada faktorů, které jsou uvedeny v tabulce 1 (2,4,10,11,12,16,17,23,25,26,28).…”

Section: úVodunclassified

Surgical Treatment of Spinal Infections

Klézl¹,

Štulík²,

Kryl³

et al. 2007

Acta Chir. orthop. Traum. Cech.

View full text Add to dashboard Cite

PURPOSE OF THE STUDYAlthough great advances have been made in both radiological diagnosis and antibiotic therapy of microbial infections, the treatment of spinal infections remains a major clinical challenge. Many of the patients affected are referred to spinal units with long delays. The general population is ageing and the number of immunocompromised patients, as well as the number of operative procedures for spinal disorders are increasing. The aim of our study was to evaluate the clinical presentations of spinal infections, options for their diagnosis, indications for treatment and their risk factors and the results of surgery. MATERIAL AND METHODSThe group of 112 patients evaluated after the treatment of spinal infection comprised 63 men and 49 women at an average age of 59.4 years (range, 17 to 84). The average follow-up was 3.2 years (range, 6 months to 8 years). Of these, 82 patients had primary hematogenous infection, 29 had post-operative infection,and one had an infected gun shot wound. Thirty-six patients showed neurological deficit and six were paraplegic. The diagnostic methods included FBC, CRP and EST tests, examination of blood cultures, aspirates and biopsy samples from the infected site, bone scintigraphy, MRI and CT scanning. Indications for surgery included an infection not responding to conservative treatment,with existing or impending spinal instability, and with or without neurological deficit.The surgical management involved transpedicular drainage of the abscess, wound debridement from the posterior approach and instrumented spondylodesis. Surgery which included spinal decompression with radical excision of infected tissue was augmented with posterolateral instrumented fusion and/or anterior stabilization, as indicated. RESULTSOf the 112 patients treated, seven died of uncontrollable sepsis after surgery; the remaining 105 were followed up. Another four patients died of causes unrelated to the spinal problem treated within 12 months. All patients recovered except for two in whom the infection persisted, but 13 required more than one surgical procedure. One patient with CSF leakage failed to heal after five interventions. The most frequently isolated infectious agents were Staphylococus aureus, Staphylococus epidermidis and E. coli. Of the 33 patients with neurological deficit, 24 improved by one or two Frankel grades. The neurological status of six paraplegic patients did not improve, but their functional findings did after stabilization of the spine. Clinical evaluation showed 47 (44.7 %) very good, 40 (38 %) good, eight (7.6 %) unchanged and 10 (9.5 %) poor outcomes. CONCLUSIONEarly diagnosis is a prerequisite for good treatment outcomes. Clinical examination, results of laboratory tests, and scintigraphy and MRI findings play the key role. When progressing osteolysis is suspected, a CT scan is necessary. Debridement should be as radical as possible, but always in compliance with the patient's health state. At an advanced stage of disease, spinal stabilization is important because it a...

show abstract

Crohn's Disease and Discitis

Cited by 5 publications

References 2 publications

Piriformis Muscle Abscess Complicating Crohnʼs Ileitis

Piriformis Muscle Abscess Complicating Crohnʼs Ileitis

Spondylodiscitis representing as the very first sign of Crohnʼs disease

Surgical Treatment of Spinal Infections

Contact Info

Product

Resources

About