Crohn's Colitis: The Incidence of Dysplasia and Adenocarcinoma in Surgical Patients

Maykel, Justin A.; Hagerman, Gonzalo; Mellgren, Anders; Li, Shelby Y.; Alavi, Karim; Baxter, Nancy N.; Madoff, Robert D.

doi:10.1007/s10350-006-0555-9

Cited by 72 publications

(28 citation statements)

References 51 publications

(43 reference statements)

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“…Although few studies have adequately investigated this issue, the risk for large bowel cancer seems to be similar to that seen with ulcerative colitis. 65,66 Consequently, patients with colitis often are advised to undergo a screening colonoscopy after eight to ten years of disease symptoms, and surveillance endoscopy every one to two years thereafter. 67 Ideally, surveillance colonoscopy should be performed when the disease is in remission to minimize confusion interpreting neoplastic changes.…”

Section: Operative Indicationsmentioning

confidence: 99%

Practice Parameters for the Surgical Management of Crohn's Disease

Strong¹,

Koltun²,

Hyman³

et al. 2007

Diseases of the Colon &Amp; Rectum

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Section: Operative Indicationsmentioning

confidence: 99%

Practice Parameters for the Surgical Management of Crohn's Disease

Strong¹,

Koltun²,

Hyman³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…Chronic inflammatory conditions of the bowel, including ulcerative colitis, Crohn's disease, and celiac disease, have been associated with increased malignancy, including adenocarcinoma and lymphoproliferative disorders [7][8][9][10][11][12][13]. In these conditions, chronic inflammation is considered to be a risk factor for the development of neoplasia.…”

Section: Introductionmentioning

confidence: 98%

Decreased Colorectal Cancer and Adenoma Risk in Patients with Microscopic Colitis

et al. 2011

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“…Thus, colonoscopy with biopsies and brushing to evaluate malignancy is highly recommended, particularly when the disease is diagnosed at an older age, after longer disease duration, and with more extensive colon involvement (11)(12)(13). In our study, we showed that pathologic examination of the stricture(s) revealed no dysplasia or malignancy.…”

Section: Original Articlementioning

confidence: 56%

Characterization of de novo colonic stricture due to Crohn’s disease

Başaranoğlu

Sayılır²,

Yüksel³

et al. 2015

Turk J Gastroenterol

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Background/Aims: The development of colonic stenosis is a rare complication of Crohn's disease (CD) without a surgical anastomosis history. So, the management and long-term follow-up results of colonic stricture due to CD have not been clearly defined. In this study, we aimed to characterize de novo colonic stricture due to CD. Materials and Methods: We evaluated 702 patients with CD to investigate colonic stricture. Colonic stricture was considered to exist when passage of a standard colonoscope was not possible and was diagnosed radiologically and endoscopically in this study. Results: Of the 702 patients, 14 had colonic stricture according to the definition above. Of the 14, 8 were male. The interval between diagnosis of disease and recognition of the stricture varied from 0 to 13 years. Localization of the strictures differed from the rectum to cecum. Of the 14, 3 patients had more than 1 stricture. Pathological examination of the stricture(s) did not show dysplasia or malignancy initially or during the follow-up. Conclusion: De novo colonic stricture due to CD is a rare condition according to the presented study's results. Distribution of the stricture(s) varied from the rectum to cecum without increased colonic cancer risk. We observed the antifibrotic role of thiopurines and biologic agents in this study.

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Crohn's Colitis: The Incidence of Dysplasia and Adenocarcinoma in Surgical Patients

Abstract: Patients with severe Crohn's colitis requiring surgery are at significant risk for developing dysplasia and adenocarcinoma, particularly when diagnosed at an older age, after longer disease duration, and with more extensive colon involvement.

Cited by 72 publications

References 51 publications

Practice Parameters for the Surgical Management of Crohn's Disease

Practice Parameters for the Surgical Management of Crohn's Disease

Decreased Colorectal Cancer and Adenoma Risk in Patients with Microscopic Colitis

Characterization of de novo colonic stricture due to Crohn’s disease

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