Decreased Colorectal Cancer and Adenoma Risk in Patients with Microscopic Colitis

Abstract

In this case-control study involving a large retrospective cohort, microscopic colitis is negatively associated with the risk for colorectal cancer and adenoma. Further studies are required to determine a temporal relationship between microscopic colitis and the future development of colorectal neoplasia.

Low Prevalence of Colon Polyps in Chronic Inflammatory Conditions of the Colon

“…No such decreased polyp prevalence was observed in patients who underwent colonoscopy and were found to have diverticulitis or ischemic colitis. As in two previous studies, we observed a striking inverse association between microscopic colitis and the occurrence of colonic neoplasms ( 1,2 ). In the present study, the control population consisted of subjects with similar symptoms and indications for colonoscopy as the case population of patients with microscopic colitis.…”

“…Previous studies have reported a low prevalence of colon polyps in patients with microscopic colitis ( 1,2 ). It might be speculated, however, that as the endoscopists' attention was focused on the mucosal appearance and fi nding potential causes for the patients' symptoms, less polyps became excised during such colonoscopies aimed at the work-up of diarrhea.…”

Are collagenous and lymphocytic colitis different aspects of the same disease?

“…Since the reported risk for colorectal cancer or adenomas in patients with MC is not increased [19,20] and the treatment is fairly much the same in both CC and LC, it is not common with repeated endoscopies, for example after a relapse. As a consequence information is lacking on any putative changes in histology during the disease course.…”

Microscopic Colitis and Colorectal Neoplastic Lesion Rate in Chronic Nonbloody Diarrhea

“…MC patients are more likely to be women than men. 3,30 To our knowledge, there is no study designed to untangle this issue. 3,[18][19][20][21][22][23][24] In recent years, MC is emerging as a common finding among subjects undergoing colonoscopy and biopsy sampling for CNBD, resulting in 10%-20% of cases with a striking agedependent rise.…”