Critical review of the current literature on the safety of sucralose

Magnuson, Bernadene A.; Roberts, Ashley; Nestmann, Earle R.

doi:10.1016/j.fct.2017.05.047

Cited by 105 publications

(70 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En los resultados, no se encontró diferencia significativa entre los tratamientos y el control; sin embargo, en otro estudio realizado por Bian et al(44), concentraciones de 0,1 mg/mL de sucralosa equivalentes a la IDR describen una alteración de la microbiota intestinal que desencadenó una inflamación crónica en el hígado de los ratones, por lo que no descartan un efecto adverso, aun consumiendo las cantidades permitidas de 5 mg/kg/día. Por otro lado, Magnuson et al(50) expusieron una serie de investigaciones en las que concuerdan en que el consumo de sucralosa es seguro, al no encontrar en la literatura evidencia suficiente para demostrar toxicidad, daño celular, alteración de ADN, ni en humanos ni en animales. Por ello, los autores ponen en duda los reportes en los cuales se demuestra el efecto adverso del consumo de este edulcorante.…”

unclassified

Consumo de edulcorantes no nutritivos: efectos a nivel celular y metabólico

Stephens-Camacho

Valdez-Hurtado

Lastra-Zavala

et al. 2018

Perspect Nutr Humana

View full text Add to dashboard Cite

ResumenAntecedentes: la función principal de los edulcorantes no nutritivos es proveer al consumidor un producto dulce sin la carga calórica del azúcar. El consumo de edulcorantes no nutritivos se relaciona con alteraciones en el ADN, con apoptosis y con la síntesis de precursores de cáncer. Además, su consumo también se relaciona recientemente con un incremento de tejido adiposo. Objetivo: analizar el efecto de los edulcorantes no nutritivos a largo plazo, evaluando el riesgo de estos compuestos. Materiales y métodos: búsqueda en bases de datos, PubMed, SciELO y Redalyc, y análisis de bibliografía relacionada con efectos tóxicos y metabólicos del consumo de edulcorantes no nutritivos. Resultados: el consumo de estos edulcorantes presentó efectos citotóxicos en diferentes modelos de estudio. Parece existir una relación con el incremento en la síntesis de tejido adiposo, que provoca obesidad y enfermedades derivadas. Los edulcorantes sintéticos fueron los que presentaron más alteraciones citotóxicas, mientras que edulcorantes naturales, a excepción de los esteviósidos, no presentaron efectos adversos. Múltiples investigaciones explican el efecto del consumo de estos edulcorantes en el metabolismo y los efectos citotóxicos. Conclusiones: el tema de edulcorantes es controversial, por ello la información recopilada en esta revisión busca proporcionar un panorama que ayude a comprender la respuesta a nivel celular y metabólico sobre su consumo.Palabras clave: edulcorante no nutritivo, edulcorante, toxicidad, efectos adversos, diabetes mellitus. AbstractBackground: The primary function of non-nutritive sweeteners is to provide the consumer with a sweet product without the caloric load of sugar. The consumption of non-nutritive sweeteners is related to alterations in DNA, apoptosis, and the synthesis of cancer precursors. Recently, its consumption has been related to an increase in adipose tissue. Objective: To analyze the effect of long-term consumption of these sweeteners and evaluate the risk of these related factors. Materials and Methods: Pubmed, Scielo and Redalyc database search and analysis of references related to toxic and metabolic effects of consumption of non-nutritrive sweeteners. Results: The consumption presents cytotoxic effects in different study models. There appears to be a relationship with an increase in synthesis of adipose tissue, which causes obesity and derived diseases. Synthetic sweeteners have the most cytotoxic alterations, whereas natural sweeteners, except steviosides, do not present adverse effects. Multiple investigations explain the impact of nonnutritive sweetener consumption on metabolism and related cytotoxic effects. Conclusion: The issue of sweeteners is controversial; therefore the information compiled in this review seeks to provide a panorama that helps understand the cellular and metabolic level responses of their consumption.

show abstract

unclassified

Consumo de edulcorantes no nutritivos: efectos a nivel celular y metabólico

Stephens-Camacho

Valdez-Hurtado

Lastra-Zavala

et al. 2018

Perspect Nutr Humana

View full text Add to dashboard Cite

show abstract

“…Furthermore, the alginate formulation used in Ummarino's study also contained sodium bicarbonate and fructose, for which the efficacy and safety in children is not yet clarified [26,27]. The magnesium-alginate formulation tested in our trial did not include antacid compounds, but did contain sucralose, considered as a safe, non-caloric, high-intensity sweetener, as an additive [28].…”

Section: Discussionmentioning

confidence: 99%

Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants

Martire

Mauro

Pignatelli

et al. 2019

IJERPH

View full text Add to dashboard Cite

The aims of this study were to evaluate the efficacy of magnesium alginate in decreasing functional regurgitation symptoms in infants, and to assess the cost–benefit ratio of magnesium alginate compared to a thickened formula. A multicenter perspective cross-over study was conducted in formula-fed infants with persisting regurgitation, randomly assigned to receive two weeks of a magnesium-alginate-based formulation followed by two weeks of thickened formula, or vice-versa. Infants, exclusively breast-fed, were followed up for two weeks while receiving magnesium alginate. Symptoms of gastroesophageal reflux (GER) were evaluated through the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R). Direct cost of treatments was also calculated. Seventy-two infants completed the study. We found a significant reduction of I-GERQ-R scores over time (F = 55.387; p < 0.001) in all groups with no difference between the sequences of administration (F = 0.268; p = 0.848) in formula-fed infants and between exclusively breast-fed and formula-fed infants receiving magnesium alginate (t = 1.55; p = 0.126). The mean cost savings per infant was € 4.60 (±11.2) in formula-fed infants treated with magnesium alginate compared to thickened formula (t = 2.91, p < 0.0005). Conclusions were that the magnesium-alginate formulation reduces GER symptoms both in formula-fed and breast-fed infants. In formula-fed infants, clinical efficacy is similar to thickened formulas with a slightly lower cost of treatment.

show abstract

“…Through the process, three atoms of chlorine are selective substitutes for three hydroxyl groups in the sucrose molecule [14] and thereby sucralose is 600 times sweeter than sucrose [15]. Extensive databases of studies on mice, rats, rabbits and dogs shows sucralose is non-teratogenic, non-carcinogenic and non-mutagenic and does not produce reproductive toxicity [16]. Due to its sugar-like taste, lack of bitter aftertaste, stability at high temperature, and long shelflife [14,17], sucralose has been widely used as a sweetener and flavor enhancer in the food industry [18].…”

Section: Introductionmentioning

confidence: 99%

Effects of sweetener sucralose on diet preference, growth performance and hematological and biochemical parameters of weaned piglets

Zhang

He²,

Gong

et al. 2020

Asian-Australas J Anim Sci

View full text Add to dashboard Cite

Objective: Two experiments were conducted to investigate the effects of dietary sucralose on diet preference and growth performance of weaned piglets, and a third experiment was a 28-d safety study to examine if high-dose sucralose could affect the health state of weaned piglets.Methods: In experiment one, 48 piglets had free access to a corn-soybean based diet and the same diet supplemented with 150 mg/kg sucralose for 15 d. In experiment two, 180 piglets were blocked into 5 treatments with 6 replications. They were fed basal diets supplemented with 0, 75, 150, 225, and 300 mg/kg sucralose for 28 days. In experiment three, 108 piglets were randomly assigned to 3 treatments and fed diets supplemented with 0, 150 (suitable level), and 1,500 (ten-fold suitable level) mg/kg sucralose for 28 d.Results: The experiment 1 showed that piglets preferred (p<0.05) diets containing sucralose during experimental period. In experiment 2, piglets fed a diet supplemented with 150 mg/kg sucralose had a higher average daily gain (ADG) and average daily feed intake (ADFI) than pigs in the control group and other treatment groups during the experiment period. The concentrations of sucralose over 150 mg/kg may decrease feed intake. However, no difference in feed conversion ratio was observed. In experiment 3, piglets fed diet supplemented with 150 mg/kg sucralose had a higher ADG and ADFI than that of pigs in the control group and 1,500 mg/kg treatment groups during the experiment period. Clinical blood metabolites, organ index and histological morphology were not significantly different between sucralose treatments.Conclusion: Sucralose can promote feed intake and thereby improve growth performance of weaned piglets. Moreover, inclusion of 1,500 mg/kg sucralose was demonstrated to have no observed adverse effects. Supplementing 150 mg/kg sucralose for weaned piglets is recommended in this study.

show abstract

Critical review of the current literature on the safety of sucralose

Cited by 105 publications

References 120 publications

Consumo de edulcorantes no nutritivos: efectos a nivel celular y metabólico

Consumo de edulcorantes no nutritivos: efectos a nivel celular y metabólico

Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants

Effects of sweetener sucralose on diet preference, growth performance and hematological and biochemical parameters of weaned piglets

Contact Info

Product

Resources

About