Critical Evaluation of Root Causes of the Reduced Compactability after Roll Compaction/Dry Granulation

Mosig, Johanna; Kleinebudde, Peter

doi:10.1002/jps.24321

Cited by 35 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particularly for MCC101, the result suggested that the granules which were roll compacted at 8 kN/cm were weaker than those roll compacted at 4 kN/cm. This is unlikely to be the case as the finding is inconsistent with the above analysis using Cooper-Eaton model and also which is reported in the literature that roll compacted granules of MCC101 at higher roll force must be harder due to the work hardening [12,40]. For mannitol powder, a small difference was obtained between the granules failure strength, which means that the strength of the granules are almost similar for granules roll compacted at 4 or 8 kN/cm.…”

Section: Adams Modelcontrasting

confidence: 60%

See 1 more Smart Citation

Analysis of densification mechanisms of dry granulated materials

Uniyal

Gandarillas

Michrafy

et al. 2020

Advanced Powder Technology

View full text Add to dashboard Cite

Dry granulation by roll compaction is a continuum manufacturing process to produce granules with improved flowability which can further be easily used in tableting process. However, the granules are non-homogeneous in density and have non-spherical shapes which impact their densification behaviour during die-compaction. The aim of this study was to investigate both the densification mechanism and the failure strength of granules of microcrystalline cellulose (MCC) and mannitol using Cooper-Eaton and Adams models. For both materials, the Cooper-Eaton approach led to the quantification of fractional volume compaction by particle rearrangement and by plastic deformation respectively to explain the difference in densification behaviour of raw material and granules. Moreover, the model showed its ability to capture the effect of granule density and granule sizes and to differentiate the densification mechanisms of MCC as a plastic material and mannitol as a brittle material. The Adams model was used to compute the failure strength of single granule from in-die compression data. The obtained results of the granules were in the range [0.6-1.43 MPa]. However, regarding the effect of granule density, the model showed mixed results indicating that the model is not representative of the studied granules which are not spherical and have a relatively wide range of sizes, nevertheless, the model was derived for near spherical particles with a narrow size distribution.

show abstract

Section: Adams Modelcontrasting

confidence: 60%

“…This tendency is opposite to that shown by MCC101 and can be due to the brittleness of mannitol behaviour. In this context, Mosig et al [40] found that for lactose, which is commonly considered as a brittle material, no sign of 'loss of reworkability' by increasing roll compaction force.…”

Section: Compaction Behaviour Based On Cooper-eaton Modelmentioning

confidence: 99%

Analysis of densification mechanisms of dry granulated materials

Uniyal

Gandarillas

Michrafy

et al. 2020

Advanced Powder Technology

View full text Add to dashboard Cite

show abstract

“…The literature suggests that the work hardening increases with increasing particle size from the same ribbon, i.e. the same density (Herting and Kleinebudde, 2008, Mosig and Kleinebudde, 2015, Perez-Gandarillas et al, 2016. The X-ray images suggest that the tablet tensile strength is based on whether the tableting stress is sufficient enough to crush the granular material, and then form strong particleparticle bonding (see Figure 3.15).…”

Section: Man0:mcc100mentioning

confidence: 99%

The effect of roller compaction and tableting stresses on pharmaceutical tablet performance

et al. 2019

View full text Add to dashboard Cite

For tablets made by roller compaction the relationships between formulation composition, manufacturing conditions and in-vitro performance were examined. Two filler materials with different characteristics were studied. During tablet production, two main stresses are experienced by a material. The first stress occurs during granulation and the second stress during tableting. These stresses were investigated in terms of the tablet properties and disintegration behaviour. Roller compaction granulation, a continuous dry granulation process, was used to produce granules. The granules were then compacted using varying tableting stresses. The tablets were characterised by their porosity and tensile strength (i.e. compactibility), and were also examined using X-ray to determine the internal tablet structure. The tablet internal structure indicated that the final tablet compactibility was dependent on the RC stress used, which governs the consequent granular properties. The granular material is then affected by the tableting stress used Publications Journal papers:  The effect of roller compaction and tableting stresses on pharmaceutical tablet performance, A

show abstract

“…The need to avert such problems in manufacturing may include the use of different tableting methods such as granulation. 1,2 Slugging, an old conventional method, is chosen for research purposes in respect to the roller compactor, which is a more modern and efficient method used for dry granulation (DG).…”

Section: Introductionmentioning

confidence: 99%