and relatively low final polydispersities (M w /M n = 1.14 -1.34). Small-angle X-ray scattering (SAXS) has been used to characterize selected examples of the spherical nanoparticles in order to obtain volume-average diameters, which increase monotonically when targeting longer DPs for the coreforming PBzMA block. A relatively high copolymer concentration (> 25 % w/v) is required to obtain a pure worm phase, which occupies an extremely narrow region within the phase diagram. Selected worm and vesicle dispersions were also analyzed by SAXS, which enables determination of the mean worm cross-section, mean worm length and vesicle membrane thickness, respectively. In addition, the highly anisotropic worms formed free-standing gels in n-heptane, with rheology measurements indicating viscoelastic behavior and a gel storage modulus of around 10 4 Pa.

For tablets made by roller compaction the relationships between formulation composition, manufacturing conditions and in-vitro performance were examined. Two filler materials with different characteristics were studied. During tablet production, two main stresses are experienced by a material. The first stress occurs during granulation and the second stress during tableting. These stresses were investigated in terms of the tablet properties and disintegration behaviour. Roller compaction granulation, a continuous dry granulation process, was used to produce granules. The granules were then compacted using varying tableting stresses. The tablets were characterised by their porosity and tensile strength (i.e. compactibility), and were also examined using X-ray to determine the internal tablet structure. The tablet internal structure indicated that the final tablet compactibility was dependent on the RC stress used, which governs the consequent granular properties. The granular material is then affected by the tableting stress used Publications Journal papers:  The effect of roller compaction and tableting stresses on pharmaceutical tablet performance, A

No abstract

IntroductionGIRFT utilises comparator data to assess variation in practice, including HES data. Context and accuracy underpin meaningful data analysis. Dashboards enable similar components of service delivery to be compared and benchmarked.MethodsDR, JH and JM, worked with JC, to develop a bespoke MS HES dashboard, utilising IQVIA’s HES dataset (from 2014), in Tableau, for people with MS accessing hospital care in England. Multiple filters relevant to clinical practice were created.ResultsConsistent MS-related activities were very inconsistently reported across Trusts. Some Trusts report infusion-related activities as elective day cases, others as elective inpatients, some report as both. For the 2019/2020 financial year, the MS variances listed below were compared for 4 Trusts (Barts Health, Univer- sity Hospitals Birmingham, University Hospital Plymouth, Salford Royal). Elective waiting list: 42%, 57%, 9%, 8%; Elective planned admissions: 38%, 3%, 5%, 74%; Elective Booked admissions: 0%, 6%, 52%, 3%. These probably represent systematic differences in reporting admission methods, rather than significant differ- ences in types of admissions, but clarification is required.ConclusionTrusts report the same activity differently in HES. We recommend enabling MS services to examine, critique and benchmark their clinical practice routinely. Cautious interpretation of MS outcome comparisons is required until data are consistently reported. Acknowledgement Roche Products Ltd provided funding but had no control over dashboard content, maintenance or distribution.davidrog@srft.nhs.uk78