Criteria for the diagnosis of dysplasia by endoscopic optical coherence tomography

Pfau, Patrick R.; Sivak, Michael; Chak, Amitabh; Kinnard, Margaret; Wong, Richard C.K.; Isenberg, Gerard; Izatt, Joseph A.; Rollins, Andrew M.; Westphal, Volker

doi:10.1067/mge.2003.344

Cited by 123 publications

(74 citation statements)

References 19 publications

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“…3(C). Our findings are consistent with previous animal study [59] and clinical observations of reduced OCT scattered light in adenomatous polyps of the human colon [72]. Another observation is the heterogeneity in the tumor region [73] as shown in Fig.…”

Section: Structural and Molecular Biomarkerssupporting

confidence: 93%

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Tang

Wang

Frank

et al. 2016

Biomed. Opt. Express

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Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity) parameters were obtained from OCT and FLOT images for multi-parametric analysis. This multi-modal imaging method has demonstrated the feasibility for more accurate diagnosis with 88.23% (82.35%) for sensitivity (specificity) compared to either modality alone. This study suggested that combining OCT and FLOT is promising for subsurface cancer detection, diagnosis, and characterization. Muthasamy, C. J. Lightdale, N. Santiago, D. K. Pleskow, P. J. Dean, and K. K. Wang, "Endoscopic radiofrequency ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trial," Endoscopy 42(10), 781-789 (2010 cancer lesion with swept-source optical coherence tomography," J.

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Section: Structural and Molecular Biomarkerssupporting

confidence: 93%

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Tang

Wang

Frank

et al. 2016

Biomed. Opt. Express

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“…In recent years, large amounts of research have focused on developing optical methods for early cancer detection [2][3][4] because such methods hold great promise to overcome the limitations of the traditional biopsy listed earlier. One specific technique, elastic light scattering spectroscopy, is an optical technique that analyzes scattered light to obtain information about the structures with which the light interacts.…”

Section: Introductionmentioning

confidence: 99%

Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations

et al. 2009

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Abstract. We have developed a novel dual-window approach for spectroscopic optical coherence tomography ͑OCT͒ measurements and applied it to probe nuclear morphology in tissue samples drawn from the hamster cheek pouch carcinogenesis model. The dualwindow approach enables high spectral and depth resolution simultaneously, allowing detection of spectral oscillations, which we isolate to determine the structure of cell nuclei in the basal layer of the epithelium. The measurements were executed with our parallel frequency domain OCT system, which uses light from a thermal source, providing high bandwidth and access to the visible portion of the spectrum. The structural measurements show a highly statistically significant difference between untreated ͑normal͒ and treated ͑hyperplastic/dysplastic͒ tissues, indicating the potential utility of this approach as a diagnostic method.

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“…[6][7][8]18 These criteria were specific to imaging with a catheter that did not compress the esophageal wall. It is unclear whether tissue compression arising from the balloon will adversely affect the accuracy of OCT diagnostic criteria; additional studies will be required.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,5 The small size (~250 μm) of an optical fiber further allows imaging probes to be configured with spacers to stabilize the position of the probe with respect to the mucosal surface while maintaining clearance through the instrument channel of standard endoscopes. 7 Although prior studies have demonstrated the diagnostic potential of endoscopic OCT, previous systems have functioned effectively in a "point-sampling" mode, wherein a probe is placed at discrete locations and cross-sectional images are obtained. The inability to screen or to survey large areas of the GI tract has limited the clinical utility of endoscopic OCT.…”

mentioning

confidence: 99%

Comprehensive esophageal microscopy by using optical frequency–domain imaging (with video)

Vakoc

Shishko

Yun

et al. 2007

Gastrointestinal Endoscopy

167

148

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Background-Optical coherence tomography (OCT) has been used for high-resolution endoscopic imaging and diagnosis of specialized intestinal metaplasia, dysplasia, and intramucosal carcinoma of the esophagus. However, the relatively slow image-acquisition rate of the present OCT systems inhibits wide-field imaging and limits the clinical utility of OCT for diagnostic imaging in patients with Barrett's esophagus.

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Criteria for the diagnosis of dysplasia by endoscopic optical coherence tomography

Cited by 123 publications

References 19 publications

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations

Comprehensive esophageal microscopy by using optical frequency–domain imaging (with video)

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