Comprehensive esophageal microscopy by using optical frequency–domain imaging (with video)

Vakoc, Benjamin J.; Shishko, Milen; Yun, Seok Hyun; Oh, Wang‐Yuhl; Suter, Melissa J.; Desjardins, Adrien E.; Evans, John A.; Nishioka, Norman S.; Tearney, Guillermo J.; Bouma, Brett E.

doi:10.1016/j.gie.2006.08.009

Cited by 167 publications

(147 citation statements)

References 19 publications

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“…This frequency-domain method offers intrinsic signal-to-noise ratio (SNR) advantage over the time-domain method [4,5]. With the recently developed rapidly tunable lasers in the 1300-nm range, OFDI has enabled significant improvements in imaging speed, sensitivity, and ranging depth over conventional time-domain OCT systems and been demonstrated for imaging skin, coronary artery, esophagus, and anterior eye segments [3,[6][7][8][9][10][11][12]. While retinal imaging is the most established clinical use of OCT, this application has been out of reach for the OFDI systems developed to date because the optical absorption in human eye at 1300 nm is too large.…”

Section: Introductionmentioning

confidence: 99%

In vivo optical frequency domain imaging of human retina and choroid

Lee¹,

Boer²,

Mujat³

et al. 2006

Opt. Express

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164

112

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Optical frequency domain imaging (OFDI) using swept laser sources is an emerging second-generation method for optical coherence tomography (OCT). Despite the widespread use of conventional OCT for retinal disease diagnostics, until now imaging the posterior eye segment with OFDI has not been possible. Here we report the development of a highperformance swept laser at 1050 nm and an ophthalmic OFDI system that offers an A-line rate of 18.8 kHz, sensitivity of >92 dB over a depth range of 2.4 mm with an optical exposure level of 550 μ W, and deep penetration into the choroid. Using these new technologies, we demonstrate comprehensive human retina, optic disc, and choroid imaging in vivo. This advance enables us to view choroidal vasculature in vivo without intravenous injection of fluorescent dyes and may provide a useful tool for evaluating choroidal as well as retinal diseases.

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Section: Introductionmentioning

confidence: 99%

In vivo optical frequency domain imaging of human retina and choroid

Lee¹,

Boer²,

Mujat³

et al. 2006

Opt. Express

Self Cite

164

112

View full text Add to dashboard Cite

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“…Studies investigated Doppler OCT to provide vascular information of the GI tract, measuring blood flow in the large vessels within or below the muscularis mucosa layer [5,33]. Conversely, OCTA techniques can visualize smaller vessels with slow flow, which are difficult to see with Doppler OCT.…”

Section: Discussionmentioning

confidence: 99%

“…However, performing OCTA endoscopically has been challenging. Early studies suggested the feasibility of identifying 2D blood flow in the human GI tract and 3D blood flow in the living swine, but did not visualize microvasculature [5,33]. Utilizing the ultrahigh imaging speed provided by VCSEL light sources and precision distal rotary scanning micromotor catheters, our group demonstrated OCTA imaging of 3D microvasculature in the human GI tract [21].…”

Section: Introductionmentioning

confidence: 99%

“…Although the fiber optic catheters in these studies were small enough to pass through the accessory port of an endoscope, imaging coverage was very limited. To increase the coverage, an OCT balloon imaging catheter was first proposed in 2000 [4] and subsequently demonstrated in living swine and human esophagus [5,6]. In contrast to positioning a small diameter imaging catheter over quadrants of the esophageal surface, the balloon catheter allows full circumferential imaging by centering the optics and expanding the esophageal lumen.…”

Section: Introductionmentioning

confidence: 99%

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Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter

Lee

Ahsen

Liang

et al. 2016

Biomed. Opt. Express

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Abstract:We demonstrate a micromotor balloon imaging catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon catheter enables circumferential imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec. Volumetric data consisting of 4200 circumferential images of 5,000 A-scans each over a 2.6 cm length, covering a ~13 cm 2 area is acquired in <18 seconds. A non-rigid image registration algorithm is used to suppress motion artifacts from non-uniform rotational distortion (NURD), cardiac motion or respiration. En face OCT images at various depths can be generated. OCT angiography (OCTA) is computed using intensity decorrelation between sequential pairs of circumferential scans and enables three-dimensional visualization of vasculature. Wide area volumetric OCT and OCTA imaging of the swine esophagus in vivo is demonstrated.

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“…Operating at a 60 kHz axial line rate required capturing and storing nearly 1 GB of data per second [65,81]. This was accomplished by streaming the data from a 2-channel, 200 MS/s digitizer to an array of hard drives.…”

Section: Data Acquisitionmentioning

confidence: 99%

Intravascular optical coherence tomography [Invited]

Bouma

Villiger

Otsuka

et al. 2017

Biomed. Opt. Express

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Shortly after the first demonstration of optical coherence tomography for imaging the microstructure of the human eye, work began on developing systems and catheters suitable for intravascular imaging in order to diagnose and investigate atherosclerosis and potentially to monitor therapy. This review covers the driving considerations of the clinical application and its constraints, the major engineering milestones that enabled the current, highperformance commercial imaging systems, the key studies that laid the groundwork for image interpretation, and the clinical research that traces intravascular optical coherence tomography (OCT) from early human pilot studies to current clinical trials. Fujimoto, "Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology," Circulation 93(6), 1206-1213 (1996). 4. D. Mozaffarian, E. Benjamin, A. Go, D. K. Arnett, M. J. Blaha, M. Cushman, S. R. Das, M. Sarah de Ferranti, J.-P. Després, and H. J. Fullerton, AHA Statistical Update: Heart Disease and Stroke Statistics (AHA, 2015). 5. E. Falk, P. K. Shah, and V. Fuster, "Coronary plaque disruption," Circulation 92(3), 657-671 (1995). 6. R. T. Lee and P. Libby, "The unstable atheroma," Arterioscler. Thromb. Vasc. Biol. 17(10), 1859-1867 (1997). 7. G. K. Sukhova, U. Schönbeck, E. Rabkin, F. J. Schoen, A. R. Poole, R. C. Billinghurst, and P. Libby, "Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques," Circulation 99(19), 2503-2509 (1999). 8. R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 20(5), 1262-1275 (2000). 9. J. A. Condado, R. Waksman, O. Gurdiel, R. Espinosa, J. Gonzalez, B. Burger, G. Villoria, H. Acquatella, I. R.Crocker, K. B. Seung, and S. F. Liprie, "Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans," Circulation 96(3), 727-732 (1997). 10. P. S. Teirstein, V. Massullo, S. Jani, J. J. Popma, G. S. Mintz, R. J. Russo, R. A. Schatz, E. M. Guarneri, S. Steuterman, N. B. Morris, M. B. Leon, and P. Tripuraneni, "Catheter-based radiotherapy to inhibit restenosis after coronary stenting," N. Engl. J. Med. 336(24), 1697-1703 (1997). 11. P. G. Yock and P. J. Fitzgerald, "Intravascular ultrasound: state of the art and future directions," Am. J. Cardiol. 81(7 7A), 27E-32E (1998). 12. P. G. Yock, P. J. Fitzgerald, D. T. Linker, and B. A. Angelsen, "Intravascular ultrasound guidance for catheterbased coronary interventions," J. Am. Coll. Cardiol. 17(6), 39-45 (1991). 13. F. M. Baer, P. Theissen, J. Crnac, M. Schmidt, M. Jochims, and H. Schicha, "MRI assessment of coronary artery disease," Rays 24(1), 46-59 (1999). 14. G. G. Zimmermann-Paul, H. H. Quick, P. Vogt, G. K. von Schulthess, D. Kling, and J. F. Debatin, "Highresolution intravascular magnetic res...

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Comprehensive esophageal microscopy by using optical frequency–domain imaging (with video)

Cited by 167 publications

References 19 publications

In vivo optical frequency domain imaging of human retina and choroid

In vivo optical frequency domain imaging of human retina and choroid

Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter

Intravascular optical coherence tomography [Invited]

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