Creation of Highly Stable Selenium Nanoparticles Capped with Hyperbranched Polysaccharide in Water

Zhang, Yifeng; Jian-guo, Wang; Zhang, Lina

doi:10.1021/la1033959

Cited by 133 publications

(65 citation statements)

References 48 publications

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“…But there are reports of preparation of Se nanoparticles with hyperbranched polysaccharide in water [39]. However, it was not prepared for any biological applications.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Selenium Incorporated Guar Gum Nanoparticle and Its Interaction with H9c2 Cells

et al. 2013

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This study deals with the preparation and characterization of selenium incorporated guar gum nanoparticle (SGG), and its effect on H9c2 cardiomyoblast. Herein, nanoprecipitation techniques had been employed for the preparation of SGG nanoparticle. The prepared nanoparticle had been subjected to various types of analytical techniques like transmission electron microscopy (TEM), X-ray diffraction (XRD) and particle size analysis to confirm the characteristics of nanoparticle as well as for selenium incorporation. Physical characterization of nanoparticle showed that the size of nanoparticles increase upto ∼69–173 nm upon selenium incorporation from ∼41–132 nm. Then the prepared nanoparticles were evaluated for its effect on H9c2 cells. In this regard, the effect of nanoparticle on various vital parameters of H9c2 cells was studied. Parameters like cell viability, uptake of selenium incorporated guar gum nanoparticle by the cells, effect of SGG on DNA integrity, apoptosis, reactive oxygen species generation, alteration in transmembrane potential of mitochondria and cytoskeletal integrity had been investigated. Viability results showed that up to 25 nM of SGG was safe (10.31%) but beyond that it induces cytotoxicity. Cellular uptake of selenium showed that cell permeability for SGG is significantly high compared to normal selenium (7.2 nM of selenium for 25 nM SGG compared with 5.2 nM selenium for 25 nM sodium selenite). There was no apoptosis with SGG and also it protects DNA from hydroxyl radical induced breakage. Likewise no adverse effect on mitochondria and cytoskeleton was observed for 25 nM of SGG. Overall results reveal that SGG is highly suitable for biomedical research application.

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“…But there are reports of preparation of Se nanoparticles with hyperbranched polysaccharide in water [39]. However, it was not prepared for any biological applications.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Selenium Incorporated Guar Gum Nanoparticle and Its Interaction with H9c2 Cells

et al. 2013

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“…Recent reviews of the role of Se in IBD have concluded that Se status and adequate dietary Se supply are of pivotal importance to colonic inflammation [26, 28]. Nanoparticles that include elemental Se (SeNPs) as a novel form of this nutrient appear to be more effective than that of other Se sources because of their excellent bioavailability, biological activity, and low toxicity [29]. To address application of ULP-SeNPs to prevent IBD, we developed a stable, homogeneous formulation of ULP-SeNPs with consistent diameter of 130 nm.…”

Section: Discussionmentioning

confidence: 99%

Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

et al. 2017

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BackgroundSelenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases progression, which involves hyper inflammation in the digestive tract. Se nanoparticles (SeNPs) exhibit anti-inflammatory activity accompanied by low toxicity, especially when decorated with natural biological compounds. Herein, we explored the beneficial effects of SeNPs decorated with Ulva lactuca polysaccharide (ULP) in mice subjected to the acute colitis model.ResultsWe constructed SeNPs coated with ULP (ULP-SeNPs) in average diameter ~130 nm and demonstrated their stability and homogeneity. Supplementation with ULP-SeNPs (0.8 ppm Se) resulted in a significant protective effect on DSS-induced acute colitis in mice including mitigation of body weight loss, and colonic inflammatory damage. ULP-SeNPs ameliorated macrophage infiltration as evidenced by decreased CD68 levels in colon tissue sections. The anti-inflammatory effects of ULP-SeNPs were found to involve modulation of cytokines including IL-6 and TNF-α. Mechanistically, ULP-SeNPs inhibited the activation of macrophages by suppressing the nuclear translocation of NF-κB, which drives the transcription of these pro-inflammatory cytokines.ConclusionsULP-SeNPs supplementation may offer therapeutic potential for reducing the symptoms of acute colitis through its anti-inflammatory actions.Electronic supplementary materialThe online version of this article (doi:10.1186/s12951-017-0252-y) contains supplementary material, which is available to authorized users.

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“…20,[44][45][46] Various sizes of selenium nanoparticles can be obtained by changing the concentration of a protein such as bovine serum albumin. 47,48 Generally, the higher the bovine serum albumin concentration, the smaller the selenium nanoparticle size.…”

Section: Discussionmentioning

confidence: 99%

Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles

Zhang¹,

Taylor²,

Wan³

et al. 2012

IJN

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Background: Elemental selenium nanoparticles have emerged as a novel selenium source with the advantage of reduced risk of selenium toxicity. The present work investigated whether heat treatment affects the size, structure, and bioactivity of selenium nanoparticles. Methods and results: After a one-hour incubation of solution containing 80 nm selenium particles in a 90°C water bath, the nanoparticles aggregated into larger 110 nm particles and nanorods (290 nm × 70 nm), leading to significantly reduced bioavailability and phase II enzyme induction in selenium-deficient mice. When a solution containing 40 nm selenium nanoparticles was treated under the same conditions, the nanoparticles aggregated into larger 72 nm particles but did not transform into nanorods, demonstrating that the thermostability of selenium nanoparticles is size-dependent, smaller selenium nanoparticles being more resistant than larger selenium nanoparticles to transformation into nanorods during heat treatment. Conclusion:The present results suggest that temperature and duration of the heat process, as well as the original nanoparticle size, should be carefully selected when a solution containing selenium nanoparticles is added to functional foods.

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Creation of Highly Stable Selenium Nanoparticles Capped with Hyperbranched Polysaccharide in Water

Cited by 133 publications

References 48 publications

Preparation and Characterization of Selenium Incorporated Guar Gum Nanoparticle and Its Interaction with H9c2 Cells

Preparation and Characterization of Selenium Incorporated Guar Gum Nanoparticle and Its Interaction with H9c2 Cells

Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles

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